Summary

Name FLNA
Full Name Filamin-A
Synonyms FLN-A, Actin-binding protein 280, ABP-280, Alpha-filamin, Endothelial actin-binding protein, Filamin-1, Non-muscle filamin | FLN, FLN1
Primary ID P21333
Links - -
Type protein
Relations 22
Pathways COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY
Inhibitors calcium(2+)
Function Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation FLNA 0.783
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png dephosphorylation FLNA 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FLNA 0.397
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation FLNA 0.263
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FLNA 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png dephosphorylation FLNA 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FLNA 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY
+ down-regulates img/direct_inhibition.png dephosphorylation FLNA 0.27
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation FLNA 0.439
Publications: 1
+ up-regulates img/direct-activation.png binding MAP2K4 0.503
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY
+ up-regulates activity img/direct-activation.png relocalization FLNA 0.557
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png binding F-actin_assembly 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding MAP2K4 0.503
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination FLNA 0.455
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png MAPK8 0.485
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY
+ up-regulates activity img/direct-activation.png binding KCND2 0.361
Publications: 1 Organism: Rattus Norvegicus
Tissue: Cerebellum
+ up-regulates img/direct-activation.png binding FLNA 0.41
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png dephosphorylation FLNA 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding FLNA 0.882
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding MAP2K7 0.263
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY
+ down-regulates activity img/direct_inhibition.png chemical inhibition FLNA 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding FLNA 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY