Entity Details

Name TAF1
ID P21675
Role kinase
Enzymatic Domains
Protein kinase 1 1-435
Bromo 1 1397-1505
PROSITE-ProRule
Protein kinase 2 1446-1893
Bromo 2 1519-1628
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
TAF1TP53Thr55DDIEQWFtEDPGPDEphosphorylation
down-regulates		15053879SIGNOR-123651
TAF1GTF2A1Ser321LNSEDDVsDEEGQELphosphorylation
up-regulates		11278496SIGNOR-105745
TAF1GTF2A1Ser280VDGTGDTsSEEDEDEphosphorylation
up-regulates activity		11278496SIGNOR-246630
TAF1GTF2A1Ser281DGTGDTSsEEDEDEEphosphorylation
up-regulates activity		11278496SIGNOR-246634
TAF1GTF2A1Ser316VEEEPLNsEDDVSDEphosphorylation
up-regulates activity		11278496SIGNOR-105688
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
TAF1phosphorylation
up-regulates
→
TP53
PThr55		phosphorylation
down-regulates
⊣		TP5315053879SIGNOR-123651
TAF1phosphorylation
up-regulates
→
GTF2A1
PSer321		phosphorylation
up-regulates
→		GTF2A111278496SIGNOR-105745
TAF1phosphorylation
up-regulates
→
GTF2A1
PSer280		phosphorylation
up-regulates
→		GTF2A111278496SIGNOR-246630
TAF1phosphorylation
up-regulates
→
GTF2A1
PSer281		phosphorylation
up-regulates
→		GTF2A111278496SIGNOR-246634
TAF1phosphorylation
up-regulates
→
GTF2A1
PSer316		phosphorylation
up-regulates
→		GTF2A111278496SIGNOR-105688
Regulator Mechanism/Effect Target SIGNOR-ID
TAF1phosphorylation
img/direct_inhibition.png
down-regulates 		TP53SIGNOR-123651
TAF1phosphorylation
→
up-regulates 		GTF2A1SIGNOR-105745
TAF1phosphorylation
→
up-regulates activity 		GTF2A1SIGNOR-246630
TAF1phosphorylation
→
up-regulates activity 		GTF2A1SIGNOR-246634
TAF1phosphorylation
→
up-regulates activity 		GTF2A1SIGNOR-105688