4.0
Summary
| Name |  TAF1View Modifications |
| Full Name | Transcription initiation factor TFIID subunit 1 |
| Synonyms | Cell cycle gene 1 protein, TBP-associated factor 250 kDa, p250, Transcription initiation factor TFIID 250 kDa subunit, TAF(II)250, TAFII-250, TAFII250 | BA2R, CCG1, CCGS, TAF2A |
| Primary ID | P21675 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Function | Largest component and core scaffold of the TFIID basal transcription factor complex (PubMed:25412659, PubMed:27007846). Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity (PubMed:25412659). Essential for progression of the G1 phase of the cell cycle (PubMed:11278496, PubMed:15053879, PubMed:2038334, PubMed:8450888, PubMed:8625415, PubMed:9660973, PubMed:9858607). Exhibits histone acetyltransferase activity towards histones H3 and H4 (PubMed:15870300). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | TAF1 | up-regulates activity 
phosphorylation
|
GTF2A1 | 0.675 |
| Publications: | 3 | Organism: | Homo Sapiens | |
| + | TAF1 | up-regulates
phosphorylation
|
GTF2A1 | 0.675 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TAF1 | down-regulates 
phosphorylation
|
TP53 | 0.682 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TAF1 | form complex 
binding
|
TFIID | 0.881 |
| Publications: | 1 | Organism: | Homo Sapiens | |