Summary

Name TAF1
Full Name Transcription initiation factor TFIID subunit 1
Synonyms Cell cycle gene 1 protein, TBP-associated factor 250 kDa, p250, Transcription initiation factor TFIID 250 kDa subunit, TAF(II)250, TAFII-250, TAFII250 | BA2R, CCG1, CCGS, TAF2A
Primary ID P21675
Links - -
Type protein
Relations 6
Function Largest component and core scaffold of the TFIID basal transcription factor complex (PubMed:25412659, PubMed:27007846). Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity (PubMed:25412659). Essential for progression of the G1 phase of the cell cycle (PubMed:11278496, PubMed:15053879, PubMed:2038334, PubMed:8450888, PubMed:8625415, PubMed:9660973, PubMed:9858607). Exhibits histone acetyltransferase activity towards histones H3 and H4 (PubMed:15870300).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation GTF2A1 0.656
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GTF2A1 0.656
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TP53 0.668
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding TFIID 0.875
Publications: 1 Organism: Homo Sapiens