Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PRKCA	CBL	Ser642 View in OncoXplorer	PRLGSTFsLDTSMSM	phosphorylation down-regulates quantity	11024037	SIGNOR-249057
HCK	CBL	–		phosphorylation unknown	10092522	SIGNOR-251262
EGFR	CBL	Tyr371 View in OncoXplorer	TQEQYELyCEMGSTF	phosphorylation up-regulates activity	29920512	SIGNOR-279998
PRKCA	CBL	Ser619 View in OncoXplorer	RELTNRHsLPFSLPS	phosphorylation down-regulates quantity	11024037	SIGNOR-249054
PRKCA	CBL	Ser623 View in OncoXplorer	NRHSLPFsLPSQMEP	phosphorylation down-regulates quantity	11024037	SIGNOR-249055
INSR	CBL	Tyr774	SENEDDGyDVPKPPV	phosphorylation up-regulates activity	11997497	SIGNOR-251306
INSR	CBL	Tyr371 View in OncoXplorer	TQEQYELyCEMGSTF	phosphorylation up-regulates activity	11997497	SIGNOR-251304
PRKCA	CBL	Ser639 View in OncoXplorer	PDVPRLGsTFSLDTS	phosphorylation down-regulates quantity	11024037	SIGNOR-249056
FYN	CBL	Tyr731	QQIDSCTyEAMYNIQ	phosphorylation up-regulates activity	9890970	SIGNOR-63968
PTK6	CBL	–		phosphorylation down-regulates activity	23352614	SIGNOR-279348
LTK	CBL	–		phosphorylation up-regulates	9223670	SIGNOR-49528
INSR	CBL	Tyr700	EGEEDTEyMTPSSRP	phosphorylation up-regulates activity	11997497	SIGNOR-251305
PRKCQ	CBL	–		phosphorylation up-regulates activity	26284074	SIGNOR-274144
PTPN22	CBL	Ser798 View in OncoXplorer	SDISNASsSFGWLSL	dephosphorylation down-regulates	10068674	SIGNOR-65405
KIT	CBL	–		phosphorylation up-regulates activity	15315962	SIGNOR-279199

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PRKCA	phosphorylation up-regulates →	CBL PSer642	phosphorylation down-regulates ⊣	CBL	11024037	SIGNOR-249057
EGFR	phosphorylation up-regulates →	CBL PTyr371	phosphorylation up-regulates →	CBL	29920512	SIGNOR-279998
PRKCA	phosphorylation up-regulates →	CBL PSer619	phosphorylation down-regulates ⊣	CBL	11024037	SIGNOR-249054
PRKCA	phosphorylation up-regulates →	CBL PSer623	phosphorylation down-regulates ⊣	CBL	11024037	SIGNOR-249055
INSR	phosphorylation up-regulates →	CBL PTyr774	phosphorylation up-regulates →	CBL	11997497	SIGNOR-251306
INSR	phosphorylation up-regulates →	CBL PTyr371	phosphorylation up-regulates →	CBL	11997497	SIGNOR-251304
PRKCA	phosphorylation up-regulates →	CBL PSer639	phosphorylation down-regulates ⊣	CBL	11024037	SIGNOR-249056
FYN	phosphorylation up-regulates →	CBL PTyr731	phosphorylation up-regulates →	CBL	9890970	SIGNOR-63968
INSR	phosphorylation up-regulates →	CBL PTyr700	phosphorylation up-regulates →	CBL	11997497	SIGNOR-251305
PTPN22	dephosphorylation down-regulates ⊣	CBL PSer798	dephosphorylation up-regulates →	CBL	10068674	SIGNOR-65405

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PRKCA	phosphorylation → down-regulates quantity	CBL	SIGNOR-249057
HCK	phosphorylation → unknown	CBL	SIGNOR-251262
EGFR	phosphorylation → up-regulates activity	CBL	SIGNOR-279998
PRKCA	phosphorylation → down-regulates quantity	CBL	SIGNOR-249054
PRKCA	phosphorylation → down-regulates quantity	CBL	SIGNOR-249055
INSR	phosphorylation → up-regulates activity	CBL	SIGNOR-251306
INSR	phosphorylation → up-regulates activity	CBL	SIGNOR-251304
PRKCA	phosphorylation → down-regulates quantity	CBL	SIGNOR-249056
FYN	phosphorylation → up-regulates activity	CBL	SIGNOR-63968
PTK6	phosphorylation → down-regulates activity	CBL	SIGNOR-279348
LTK	phosphorylation → up-regulates	CBL	SIGNOR-49528
INSR	phosphorylation → up-regulates activity	CBL	SIGNOR-251305
PRKCQ	phosphorylation → up-regulates activity	CBL	SIGNOR-274144
PTPN22	dephosphorylation down-regulates	CBL	SIGNOR-65405
KIT	phosphorylation → up-regulates activity	CBL	SIGNOR-279199