Summary

Name CBL
Full Name E3 ubiquitin-protein ligase CBL
Synonyms Casitas B-lineage lymphoma proto-oncogene, Proto-oncogene c-Cbl, RING finger protein 55, Signal transduction protein CBL | CBL2, RNF55
Primary ID P22681
Links - -
Type protein
Relations 55
Pathways Acute Myeloid Leukemia, FLT3 in AML, KIT in AML, Glioblastoma Multiforme
Function Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:17094949). Ubiquitinates SPRY2 (PubMed:17094949, PubMed:17974561). Ubiquitinates EGFR (PubMed:17974561). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity).

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination JAK2 0.586
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, KIT in AML
+ down-regulates quantity img/direct_inhibition.png phosphorylation CBL 0.323
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation CBL 0.388
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CBL 0.525
Publications: 3 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation CBL 0.812
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination ABL1 0.614
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination LRIG1 0.587
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ down-regulates img/direct_inhibition.png ubiquitination PIK3R2 0.604
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png ubiquitination CBL 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CBL 0.444
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination CFLAR 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization CBL 0.886
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Glioblastoma Multiforme
+ down-regulates activity img/direct_inhibition.png ubiquitination SYK 0.815
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CBL 0.645
Publications: 2 Organism: Cricetulus Griseus, Homo Sapiens
Tissue: Ovary
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination PDGFRB 0.627
Publications: 2 Organism: Mus Musculus, Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination PI3K 0.61
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, KIT in AML
+ down-regulates img/direct_inhibition.png ubiquitination PIK3R1 0.693
Publications: 1 Organism: Homo Sapiens
Pathways:Glioblastoma Multiforme
+ up-regulates activity img/direct-activation.png phosphorylation CBL 0.356
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding CBL 0.687
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates activity img/direct-activation.png monoubiquitination MYCBPAP 0.298
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CBL 0.746
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CBL 0.575
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png CBL 0.324
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination MET 0.731
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CBL 0.397
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination SORBS2 0.514
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding EPHA2 0.637
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CBL 0.691
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CBL 0.37
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding FLT3 0.438
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3 in AML
+ down-regulates img/direct_inhibition.png ubiquitination INSR 0.525
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation CBL 0.666
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination PDGFRA 0.477
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CBL 0.824
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination NCK1 0.643
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png ubiquitination KIT 0.616
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, KIT in AML
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination LCK 0.71
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization CBL 0.905
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, KIT in AML, Glioblastoma Multiforme
+ down-regulates img/direct_inhibition.png ubiquitination FRS2 0.574
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CBL 0.587
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination ERBB2 0.604
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png ubiquitination SYK 0.815
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CBL 0.372
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination EGFR 0.886
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Glioblastoma Multiforme
+ down-regulates quantity img/direct_inhibition.png ubiquitination LCK 0.71
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination SRC 0.737
Publications: 1 Organism: Homo Sapiens