| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| INSR | CBL | Tyr371 | TQEQYELyCEMGSTF | phosphorylation up-regulates activity | 11997497 | SIGNOR-251304 |
| EGFR | CBL | Tyr371 | TQEQYELyCEMGSTF | phosphorylation up-regulates activity | 29920512 | SIGNOR-279998 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| INSR | phosphorylation up-regulates → | CBL PTyr371 | phosphorylation up-regulates → | CBL | 11997497 | SIGNOR-251304 |
| EGFR | phosphorylation up-regulates → | CBL PTyr371 | phosphorylation up-regulates → | CBL | 29920512 | SIGNOR-279998 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| INSR | phosphorylation → up-regulates activity | CBL | SIGNOR-251304 |
| EGFR | phosphorylation → up-regulates activity | CBL | SIGNOR-279998 |