| Name | RPS6KB1 |
| ID | P23443 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 91-352 PROSITE-ProRule
AGC-kinase C-terminal 353-423 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KB1 | BAD | – | phosphorylation down-regulates activity | 24771995 | SIGNOR-280016 | |
| RPS6KB1 | SREBF1 | – | phosphorylation up-regulates activity | 33240877 | SIGNOR-280120 | |
| RPS6KB1 | RPS6 | Ser235 | IAKRRRLsSLRASTS | phosphorylation up-regulates activity | 15809305 | SIGNOR-135172 |
| RPS6KB1 | POLDIP3 | Ser385 | PRRVNSAsSSNPPAE | phosphorylation unknown | 15341740 | SIGNOR-128499 |
| RPS6KB1 | PDCD4 | Ser67 | KRRLRKNsSRDSGRG | phosphorylation down-regulates | 17053147 | SIGNOR-150144 |
| RPS6KB1 | URI1 | Ser372 | AKRKRKNsTGSGHSA | phosphorylation down-regulates activity | 17936702 | SIGNOR-262943 |
| RPS6KB1 | PPP1R1B | – | phosphorylation up-regulates activity | 33353667 | SIGNOR-279654 | |
| RPS6KB1 | HSPB1 | Ser78 | PAYSRALsRQLSSGV | phosphorylation down-regulates | 19593530 | SIGNOR-186955 |
| RPS6KB1 | TARBP2 | Ser286 | LRSCSLGsLGALGPA | phosphorylation up-regulates activity | 27407113 | SIGNOR-274068 |
| RPS6KB1 | IRS1 | Ser1101 | GCRRRHSsETFSSTP | phosphorylation down-regulates activity | 15306821 | SIGNOR-127904 |
| RPS6KB1 | SRPK2 | – | phosphorylation up-regulates activity | 35674408 | SIGNOR-280121 | |
| RPS6KB1 | RICTOR | Thr1135 | NRRIRTLtEPSVDFN | phosphorylation down-regulates | 19995915 | SIGNOR-161995 |
| RPS6KB1 | PDCD4 | Ser67 | KRRLRKNsSRDSGRG | phosphorylation down-regulates | 18296647 | SIGNOR-160989 |
| RPS6KB1 | IRS1 | Ser639 | YMPMSPKsVSAPQQI | phosphorylation down-regulates quantity by destabilization | 18498745 | SIGNOR-236599 |
| RPS6KB1 | TP63 | Ser477 | NSMNKLPsVSQLINP | phosphorylation down-regulates | 18769144 | SIGNOR-180771 |
| RPS6KB1 | PIP5K1C | Ser555 | RYRRRTQsSGQDGRP | phosphorylation down-regulates quantity by destabilization | 27780861 | SIGNOR-277283 |
| RPS6KB1 | DEPTOR | Ser286 | SSMSSCGsSGYFSSS | phosphorylation down-regulates | 22017876 | SIGNOR-176858 |
| RPS6KB1 | MXD1 | Ser145 | IERIRMDsIGSTVSS | phosphorylation down-regulates | 18451027 | SIGNOR-178590 |
| RPS6KB1 | EPRS1 | Ser999 | NQGGGLSsSGAGEGQ | phosphorylation up-regulates activity | 28178239 | SIGNOR-279483 |
| RPS6KB1 | EIF4B | Ser422 | RERSRTGsESSQTGT | phosphorylation up-regulates | 15071500 | SIGNOR-123997 |
| RPS6KB1 | TP63 | Thr491 | PQQRNALtPTTIPDG | phosphorylation down-regulates | 18769144 | SIGNOR-180784 |
| RPS6KB1 | IRS1 | Ser270 | EFRPRSKsQSSSNCS | phosphorylation down-regulates activity | 9312143 | SIGNOR-51216 |
| RPS6KB1 | TRIB2 | Ser83 | FRAVHLHsGEELVCK | phosphorylation down-regulates quantity by destabilization | 24089522 | SIGNOR-275433 |
| RPS6KB1 | DEPTOR | Ser287 | SMSSCGSsGYFSSSP | phosphorylation down-regulates | 22017876 | SIGNOR-176862 |
| RPS6KB1 | POLDIP3 | Ser383 | ELPRRVNsASSSNPP | phosphorylation unknown | 15341740 | SIGNOR-128495 |
| RPS6KB1 | LTC4S | Ser36 | ARRAFRVsPPLTTGP | phosphorylation down-regulates activity | 27365393 | SIGNOR-277256 |
| RPS6KB1 | IRS1 | Ser639 | YMPMSPKsVSAPQQI | phosphorylation down-regulates activity | 15306821 | SIGNOR-127203 |
| RPS6KB1 | CAD | Ser1859 | PPRIHRAsDPGLPAE | phosphorylation up-regulates | 23429703 | SIGNOR-201117 |
| RPS6KB1 | GLI1 | Ser84 | LTKKRALsISPLSDA | phosphorylation up-regulates | 22439934 | SIGNOR-196756 |
| RPS6KB1 | CAD | Ser1859 | PPRIHRAsDPGLPAE | phosphorylation up-regulates activity | 23429703 | SIGNOR-267443 |
| RPS6KB1 | IRS1 | Ser527 | RFRKRTHsAGTSPTI | phosphorylation down-regulates quantity by destabilization | 18498745 | SIGNOR-236595 |
| RPS6KB1 | TARBP2 | Ser283 | ILSLRSCsLGSLGAL | phosphorylation up-regulates activity | 27407113 | SIGNOR-274065 |
| RPS6KB1 | TP63 | Ser560 | LARLGCSsCLDYFTT | phosphorylation down-regulates | 18769144 | SIGNOR-180775 |
| RPS6KB1 | IRS1 | Ser527 | RFRKRTHsAGTSPTI | phosphorylation down-regulates activity | 16914728 | SIGNOR-148903 |
| RPS6KB1 | PFKFB2 | Ser466 | PVRMRRNsFTPLSSS | phosphorylation up-regulates activity | 9211863 | SIGNOR-49371 |
| RPS6KB1 | CCT2 | Ser260 | GSRVRVDsTAKVAEI | phosphorylation unknown | 19332537 | SIGNOR-184926 |
| RPS6KB1 | IRS1 | Ser636 | SGDYMPMsPKSVSAP | phosphorylation down-regulates activity | 15306821 | SIGNOR-127912 |
| RPS6KB1 | PDPK1 | Ser549 | VWRQRYQsHPDAAVQ | phosphorylation down-regulates activity | 35318320 | SIGNOR-273844 |
| RPS6KB1 | HSPB1 | Ser82 | RALSRQLsSGVSEIR | phosphorylation down-regulates | 19593530 | SIGNOR-186959 |
| RPS6KB1 | PIP5K1C | Thr553 | QPRYRRRtQSSGQDG | phosphorylation down-regulates quantity by destabilization | 27780861 | SIGNOR-277282 |
| RPS6KB1 | MRE11 | Thr597 | SQRGRADtGLETSTR | phosphorylation down-regulates quantity by destabilization | 28967905 | SIGNOR-265944 |
| RPS6KB1 | SRPK2 | Ser494 | HDRSRTVsASSTGDL | phosphorylation up-regulates activity | 29153836 | SIGNOR-275459 |
| RPS6KB1 | HSPB1 | Ser15 | FSLLRGPsWDPFRDW | phosphorylation down-regulates | 19593530 | SIGNOR-186951 |
| RPS6KB1 | MAPKAP1 | – | phosphorylation down-regulates activity | 24161930 | SIGNOR-279568 | |
| RPS6KB1 | MXI1 | Ser160 | MERIRMDsIGSTISS | phosphorylation down-regulates activity | 29507620 | SIGNOR-278231 |
| RPS6KB1 | IRS1 | Ser307 | TRRSRTEsITATSPA | phosphorylation down-regulates activity | 15306821 | SIGNOR-127908 |
| RPS6KB1 | EEF2K | Ser366 | SPQVRTLsGSRPPLL | phosphorylation down-regulates activity | 11500364 | SIGNOR-109712 |
| RPS6KB1 | RPS6 | Ser236 | AKRRRLSsLRASTSK | phosphorylation up-regulates activity | 15809305 | SIGNOR-135176 |
| RPS6KB1 | ESR1 | Ser167 | GGRERLAsTNDKGSM | phosphorylation up-regulates | 7838153 | SIGNOR-34117 |
| RPS6KB1 | MTOR | Thr2446 | NKRSRTRtDSYSAGQ | phosphorylation down-regulates activity | 15905173 | SIGNOR-102051 |
| RPS6KB1 | PFKFB2 | Ser466 | PVRMRRNsFTPLSSS | phosphorylation up-regulates activity | 2846551 | SIGNOR-23757 |
| RPS6KB1 | DEPTOR | Ser291 | CGSSGYFsSSPTLSS | phosphorylation down-regulates | 22017876 | SIGNOR-176866 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KB1 | phosphorylation up-regulates → | RPS6 PSer235 | phosphorylation up-regulates → | RPS6 | 15809305 | SIGNOR-135172 |
| RPS6KB1 | phosphorylation up-regulates → | POLDIP3 PSer385 | phosphorylation down-regulates ⊣ | POLDIP3 | 15341740 | SIGNOR-128499 |
| RPS6KB1 | phosphorylation up-regulates → | PDCD4 PSer67 | phosphorylation down-regulates ⊣ | PDCD4 | 17053147 | SIGNOR-150144 |
| RPS6KB1 | phosphorylation up-regulates → | URI1 PSer372 | phosphorylation down-regulates ⊣ | URI1 | 17936702 | SIGNOR-262943 |
| RPS6KB1 | phosphorylation up-regulates → | HSPB1 PSer78 | phosphorylation down-regulates ⊣ | HSPB1 | 19593530 | SIGNOR-186955 |
| RPS6KB1 | phosphorylation up-regulates → | TARBP2 PSer286 | phosphorylation up-regulates → | TARBP2 | 27407113 | SIGNOR-274068 |
| RPS6KB1 | phosphorylation up-regulates → | IRS1 PSer1101 | phosphorylation down-regulates ⊣ | IRS1 | 15306821 | SIGNOR-127904 |
| RPS6KB1 | phosphorylation up-regulates → | RICTOR PThr1135 | phosphorylation down-regulates ⊣ | RICTOR | 19995915 | SIGNOR-161995 |
| RPS6KB1 | phosphorylation up-regulates → | PDCD4 PSer67 | phosphorylation down-regulates ⊣ | PDCD4 | 18296647 | SIGNOR-160989 |
| RPS6KB1 | phosphorylation up-regulates → | IRS1 PSer639 | phosphorylation down-regulates ⊣ | IRS1 | 18498745 | SIGNOR-236599 |
| RPS6KB1 | phosphorylation up-regulates → | TP63 PSer477 | phosphorylation down-regulates ⊣ | TP63 | 18769144 | SIGNOR-180771 |
| RPS6KB1 | phosphorylation up-regulates → | PIP5K1C PSer555 | phosphorylation down-regulates ⊣ | PIP5K1C | 27780861 | SIGNOR-277283 |
| RPS6KB1 | phosphorylation up-regulates → | DEPTOR PSer286 | phosphorylation down-regulates ⊣ | DEPTOR | 22017876 | SIGNOR-176858 |
| RPS6KB1 | phosphorylation up-regulates → | MXD1 PSer145 | phosphorylation down-regulates ⊣ | MXD1 | 18451027 | SIGNOR-178590 |
| RPS6KB1 | phosphorylation up-regulates → | EPRS1 PSer999 | phosphorylation up-regulates → | EPRS1 | 28178239 | SIGNOR-279483 |
| RPS6KB1 | phosphorylation up-regulates → | EIF4B PSer422 | phosphorylation up-regulates → | EIF4B | 15071500 | SIGNOR-123997 |
| RPS6KB1 | phosphorylation up-regulates → | TP63 PThr491 | phosphorylation down-regulates ⊣ | TP63 | 18769144 | SIGNOR-180784 |
| RPS6KB1 | phosphorylation up-regulates → | IRS1 PSer270 | phosphorylation down-regulates ⊣ | IRS1 | 9312143 | SIGNOR-51216 |
| RPS6KB1 | phosphorylation up-regulates → | TRIB2 PSer83 | phosphorylation down-regulates ⊣ | TRIB2 | 24089522 | SIGNOR-275433 |
| RPS6KB1 | phosphorylation up-regulates → | DEPTOR PSer287 | phosphorylation down-regulates ⊣ | DEPTOR | 22017876 | SIGNOR-176862 |
| RPS6KB1 | phosphorylation up-regulates → | POLDIP3 PSer383 | phosphorylation down-regulates ⊣ | POLDIP3 | 15341740 | SIGNOR-128495 |
| RPS6KB1 | phosphorylation up-regulates → | LTC4S PSer36 | phosphorylation down-regulates ⊣ | LTC4S | 27365393 | SIGNOR-277256 |
| RPS6KB1 | phosphorylation up-regulates → | IRS1 PSer639 | phosphorylation down-regulates ⊣ | IRS1 | 15306821 | SIGNOR-127203 |
| RPS6KB1 | phosphorylation up-regulates → | CAD PSer1859 | phosphorylation up-regulates → | CAD | 23429703 | SIGNOR-201117 |
| RPS6KB1 | phosphorylation up-regulates → | GLI1 PSer84 | phosphorylation up-regulates → | GLI1 | 22439934 | SIGNOR-196756 |
| RPS6KB1 | phosphorylation up-regulates → | CAD PSer1859 | phosphorylation up-regulates → | CAD | 23429703 | SIGNOR-267443 |
| RPS6KB1 | phosphorylation up-regulates → | IRS1 PSer527 | phosphorylation down-regulates ⊣ | IRS1 | 18498745 | SIGNOR-236595 |
| RPS6KB1 | phosphorylation up-regulates → | TARBP2 PSer283 | phosphorylation up-regulates → | TARBP2 | 27407113 | SIGNOR-274065 |
| RPS6KB1 | phosphorylation up-regulates → | TP63 PSer560 | phosphorylation down-regulates ⊣ | TP63 | 18769144 | SIGNOR-180775 |
| RPS6KB1 | phosphorylation up-regulates → | IRS1 PSer527 | phosphorylation down-regulates ⊣ | IRS1 | 16914728 | SIGNOR-148903 |
| RPS6KB1 | phosphorylation up-regulates → | PFKFB2 PSer466 | phosphorylation up-regulates → | PFKFB2 | 9211863 | SIGNOR-49371 |
| RPS6KB1 | phosphorylation up-regulates → | CCT2 PSer260 | phosphorylation down-regulates ⊣ | CCT2 | 19332537 | SIGNOR-184926 |
| RPS6KB1 | phosphorylation up-regulates → | IRS1 PSer636 | phosphorylation down-regulates ⊣ | IRS1 | 15306821 | SIGNOR-127912 |
| RPS6KB1 | phosphorylation up-regulates → | PDPK1 PSer549 | phosphorylation down-regulates ⊣ | PDPK1 | 35318320 | SIGNOR-273844 |
| RPS6KB1 | phosphorylation up-regulates → | HSPB1 PSer82 | phosphorylation down-regulates ⊣ | HSPB1 | 19593530 | SIGNOR-186959 |
| RPS6KB1 | phosphorylation up-regulates → | PIP5K1C PThr553 | phosphorylation down-regulates ⊣ | PIP5K1C | 27780861 | SIGNOR-277282 |
| RPS6KB1 | phosphorylation up-regulates → | MRE11 PThr597 | phosphorylation down-regulates ⊣ | MRE11 | 28967905 | SIGNOR-265944 |
| RPS6KB1 | phosphorylation up-regulates → | SRPK2 PSer494 | phosphorylation up-regulates → | SRPK2 | 29153836 | SIGNOR-275459 |
| RPS6KB1 | phosphorylation up-regulates → | HSPB1 PSer15 | phosphorylation down-regulates ⊣ | HSPB1 | 19593530 | SIGNOR-186951 |
| RPS6KB1 | phosphorylation up-regulates → | MXI1 PSer160 | phosphorylation down-regulates ⊣ | MXI1 | 29507620 | SIGNOR-278231 |
| RPS6KB1 | phosphorylation up-regulates → | IRS1 PSer307 | phosphorylation down-regulates ⊣ | IRS1 | 15306821 | SIGNOR-127908 |
| RPS6KB1 | phosphorylation up-regulates → | EEF2K PSer366 | phosphorylation down-regulates ⊣ | EEF2K | 11500364 | SIGNOR-109712 |
| RPS6KB1 | phosphorylation up-regulates → | RPS6 PSer236 | phosphorylation up-regulates → | RPS6 | 15809305 | SIGNOR-135176 |
| RPS6KB1 | phosphorylation up-regulates → | ESR1 PSer167 | phosphorylation up-regulates → | ESR1 | 7838153 | SIGNOR-34117 |
| RPS6KB1 | phosphorylation up-regulates → | MTOR PThr2446 | phosphorylation down-regulates ⊣ | MTOR | 15905173 | SIGNOR-102051 |
| RPS6KB1 | phosphorylation up-regulates → | PFKFB2 PSer466 | phosphorylation up-regulates → | PFKFB2 | 2846551 | SIGNOR-23757 |
| RPS6KB1 | phosphorylation up-regulates → | DEPTOR PSer291 | phosphorylation down-regulates ⊣ | DEPTOR | 22017876 | SIGNOR-176866 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RPS6KB1 | phosphorylation → down-regulates activity | BAD | SIGNOR-280016 |
| RPS6KB1 | phosphorylation → up-regulates activity | SREBF1 | SIGNOR-280120 |
| RPS6KB1 | phosphorylation → up-regulates activity | RPS6 | SIGNOR-135172 |
| RPS6KB1 | phosphorylation → unknown | POLDIP3 | SIGNOR-128499 |
| RPS6KB1 | phosphorylation down-regulates | PDCD4 | SIGNOR-150144 |
| RPS6KB1 | phosphorylation → down-regulates activity | URI1 | SIGNOR-262943 |
| RPS6KB1 | phosphorylation → up-regulates activity | PPP1R1B | SIGNOR-279654 |
| RPS6KB1 | phosphorylation down-regulates | HSPB1 | SIGNOR-186955 |
| RPS6KB1 | phosphorylation → up-regulates activity | TARBP2 | SIGNOR-274068 |
| RPS6KB1 | phosphorylation → down-regulates activity | IRS1 | SIGNOR-127904 |
| RPS6KB1 | phosphorylation → up-regulates activity | SRPK2 | SIGNOR-280121 |
| RPS6KB1 | phosphorylation down-regulates | RICTOR | SIGNOR-161995 |
| RPS6KB1 | phosphorylation down-regulates | PDCD4 | SIGNOR-160989 |
| RPS6KB1 | phosphorylation down-regulates quantity by destabilization | IRS1 | SIGNOR-236599 |
| RPS6KB1 | phosphorylation down-regulates | TP63 | SIGNOR-180771 |
| RPS6KB1 | phosphorylation down-regulates quantity by destabilization | PIP5K1C | SIGNOR-277283 |
| RPS6KB1 | phosphorylation down-regulates | DEPTOR | SIGNOR-176858 |
| RPS6KB1 | phosphorylation down-regulates | MXD1 | SIGNOR-178590 |
| RPS6KB1 | phosphorylation → up-regulates activity | EPRS1 | SIGNOR-279483 |
| RPS6KB1 | phosphorylation → up-regulates | EIF4B | SIGNOR-123997 |
| RPS6KB1 | phosphorylation down-regulates | TP63 | SIGNOR-180784 |
| RPS6KB1 | phosphorylation → down-regulates activity | IRS1 | SIGNOR-51216 |
| RPS6KB1 | phosphorylation down-regulates quantity by destabilization | TRIB2 | SIGNOR-275433 |
| RPS6KB1 | phosphorylation down-regulates | DEPTOR | SIGNOR-176862 |
| RPS6KB1 | phosphorylation → unknown | POLDIP3 | SIGNOR-128495 |
| RPS6KB1 | phosphorylation → down-regulates activity | LTC4S | SIGNOR-277256 |
| RPS6KB1 | phosphorylation → down-regulates activity | IRS1 | SIGNOR-127203 |
| RPS6KB1 | phosphorylation → up-regulates | CAD | SIGNOR-201117 |
| RPS6KB1 | phosphorylation → up-regulates | GLI1 | SIGNOR-196756 |
| RPS6KB1 | phosphorylation → up-regulates activity | CAD | SIGNOR-267443 |
| RPS6KB1 | phosphorylation down-regulates quantity by destabilization | IRS1 | SIGNOR-236595 |
| RPS6KB1 | phosphorylation → up-regulates activity | TARBP2 | SIGNOR-274065 |
| RPS6KB1 | phosphorylation down-regulates | TP63 | SIGNOR-180775 |
| RPS6KB1 | phosphorylation → down-regulates activity | IRS1 | SIGNOR-148903 |
| RPS6KB1 | phosphorylation → up-regulates activity | PFKFB2 | SIGNOR-49371 |
| RPS6KB1 | phosphorylation → unknown | CCT2 | SIGNOR-184926 |
| RPS6KB1 | phosphorylation → down-regulates activity | IRS1 | SIGNOR-127912 |
| RPS6KB1 | phosphorylation → down-regulates activity | PDPK1 | SIGNOR-273844 |
| RPS6KB1 | phosphorylation down-regulates | HSPB1 | SIGNOR-186959 |
| RPS6KB1 | phosphorylation down-regulates quantity by destabilization | PIP5K1C | SIGNOR-277282 |
| RPS6KB1 | phosphorylation down-regulates quantity by destabilization | MRE11 | SIGNOR-265944 |
| RPS6KB1 | phosphorylation → up-regulates activity | SRPK2 | SIGNOR-275459 |
| RPS6KB1 | phosphorylation down-regulates | HSPB1 | SIGNOR-186951 |
| RPS6KB1 | phosphorylation → down-regulates activity | MAPKAP1 | SIGNOR-279568 |
| RPS6KB1 | phosphorylation → down-regulates activity | MXI1 | SIGNOR-278231 |
| RPS6KB1 | phosphorylation → down-regulates activity | IRS1 | SIGNOR-127908 |
| RPS6KB1 | phosphorylation → down-regulates activity | EEF2K | SIGNOR-109712 |
| RPS6KB1 | phosphorylation → up-regulates activity | RPS6 | SIGNOR-135176 |
| RPS6KB1 | phosphorylation → up-regulates | ESR1 | SIGNOR-34117 |
| RPS6KB1 | phosphorylation → down-regulates activity | MTOR | SIGNOR-102051 |
| RPS6KB1 | phosphorylation → up-regulates activity | PFKFB2 | SIGNOR-23757 |
| RPS6KB1 | phosphorylation down-regulates | DEPTOR | SIGNOR-176866 |