Summary

Name RPS6KB1
Full Name Ribosomal protein S6 kinase beta-1
Synonyms S6K-beta-1, S6K1, 70 kDa ribosomal protein S6 kinase 1, P70S6K1, p70-S6K 1, Ribosomal protein S6 kinase I, Serine/threonine-protein kinase 14A, p70 ribosomal S6 kinase alpha, p70 S6 kinase alpha, p70 S6K-alpha, p70 S6KA | STK14A
Primary ID P23443
Links - -
Type protein
Relations 83
Pathways MTOR Signaling
Function Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation. The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis. Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR. In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2. Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling. Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function. Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex. The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function. Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1. In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B. May be involved in cytoskeletal rearrangement through binding to neurabin. Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation IRS1 0.58
Publications: 6 Organism: Mus Musculus, Homo Sapiens
Tissue: Ovary, Myotube, Brain
Pathways:MTOR Signaling
+ down-regulates img/direct_inhibition.png phosphorylation MXD1 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HSPB1 0.08
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ESR1 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CAD 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RPS6 0.39
Publications: 2 Organism: Mus Musculus
Pathways:MTOR Signaling
+ up-regulates activity img/direct-activation.png phosphorylation MTOR 0.37
Publications: 3 Organism: Homo Sapiens
Tissue: A-549 Cell
Pathways:MTOR Signaling
+ img/unknown.png phosphorylation CCT2 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation DEPTOR 0.08
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EEF2K 0.39
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation POLDIP3 0.31
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KB1 0.70
Publications: 10 Organism: Sus Scrofa, Mus Musculus, Pongo Pygmaeus, In Vitro, Homo Sapiens
Tissue: Parathyroid Hormone Secreting Cell
Pathways:MTOR Signaling
+ up-regulates img/direct-activation.png phosphorylation RPS6KB1 0.34
Publications: 6 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates img/direct-activation.png phosphorylation EIF4B 0.39
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS6KB1 0.23
Publications: 10 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KB1 0.14
Publications: 3 Organism: Rattus Norvegicus, Homo Sapiens
Tissue: Carcinoma Cell
+ up-regulates activity img/direct-activation.png phosphorylation PFKFB2 0.14
Publications: 2 Organism: Homo Sapiens
Tissue: Heart
+ down-regulates img/direct_inhibition.png phosphorylation TP63 0.08
Publications: 3 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation IRS1 0.58
Publications: 3 Organism: Mus Musculus
Pathways:MTOR Signaling
+ down-regulates img/direct_inhibition.png phosphorylation PDCD4 0.34
Publications: 2 Organism: Homo Sapiens
Tissue: Skin
+ up-regulates img/direct-activation.png phosphorylation GLI1 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RICTOR 0.32
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS6KB1 0.34
Publications: 4 Organism: Homo Sapiens
Pathways:MTOR Signaling
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KB1 0.34
Publications: 1 Organism: In Vitro
Pathways:MTOR Signaling
+ down-regulates activity img/direct_inhibition.png dephosphorylation RPS6KB1 0.31
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation RPS6KB1 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KB1 0.30
Publications: 1 Organism: Pongo Pygmaeus
+ up-regulates img/direct-activation.png phosphorylation RPS6KB1 0.30
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png MAPK8 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation RPS6KB1 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png RPS6KB1 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding RPS6KB1 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png SREBF1 0.08
Publications: 1 Organism: Mus Musculus
Pathways:MTOR Signaling