| Name | RPS6KB1 |
| ID | P23443 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 91-352 PROSITE-ProRule
AGC-kinase C-terminal 353-423 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | RPS6KB1 | Thr444 | RFIGSPRtPVSPVKF | phosphorylation up-regulates activity | 15774499 | SIGNOR-134662 |
| MTOR | RPS6KB1 | Ser394 | TRQTPVDsPDDSTLS | phosphorylation up-regulates activity | 12782654 | SIGNOR-101328 |
| PDPK1 | RPS6KB1 | Thr412 | NQVFLGFtYVAPSVL | phosphorylation up-regulates | 9445476 | SIGNOR-188911 |
| CDK1 | RPS6KB1 | Ser434 | SFEPKIRsPRRFIGS | phosphorylation up-regulates | 9271440 | SIGNOR-50607 |
| MTOR | RPS6KB1 | Thr412 | NQVFLGFtYVAPSVL | phosphorylation up-regulates activity | 23486913 | SIGNOR-201538 |
| PHLPP2 | RPS6KB1 | Thr390 | DSKFTRQtPVDSPDD | dephosphorylation down-regulates activity | 21986499 | SIGNOR-248247 |
| PTEN | RPS6KB1 | – | dephosphorylation down-regulates activity | 19436944 | SIGNOR-277080 | |
| CDK1 | RPS6KB1 | Ser394 | TRQTPVDsPDDSTLS | phosphorylation up-regulates | 9271440 | SIGNOR-50603 |
| PPP2CA | RPS6KB1 | – | dephosphorylation down-regulates | 2826472 | SIGNOR-23575 | |
| MTOR | RPS6KB1 | Thr390 | DSKFTRQtPVDSPDD | phosphorylation up-regulates activity | 11914378 | SIGNOR-255839 |
| PDPK1 | RPS6KB1 | Thr252 | HDGTVTHtFCGTIEY | phosphorylation up-regulates | 19864428 | SIGNOR-188907 |
| MAPK1 | RPS6KB1 | Ser434 | SFEPKIRsPRRFIGS | phosphorylation up-regulates | 7545671 | SIGNOR-28796 |
| NEK6 | RPS6KB1 | Ser53 | EGGQLNEsMDHGGVG | phosphorylation up-regulates activity | 12023960 | SIGNOR-262952 |
| mTORC1 | RPS6KB1 | Thr412 | NQVFLGFtYVAPSVL | phosphorylation up-regulates | 10579915 | SIGNOR-217060 |
| mTORC1 | RPS6KB1 | – | phosphorylation up-regulates activity | 35318320 | SIGNOR-273843 | |
| MAPK1 | RPS6KB1 | Ser434 | SFEPKIRsPRRFIGS | phosphorylation up-regulates | 19085255 | SIGNOR-182804 |
| CDK1 | RPS6KB1 | Thr444 | RFIGSPRtPVSPVKF | phosphorylation up-regulates | 11705993 | SIGNOR-111507 |
| CDK1 | RPS6KB1 | Ser394 | TRQTPVDsPDDSTLS | phosphorylation up-regulates | 12586835 | SIGNOR-98211 |
| MAPK3 | RPS6KB1 | Ser441 | SPRRFIGsPRTPVSP | phosphorylation up-regulates activity | 15774499 | SIGNOR-111515 |
| NEK6 | RPS6KB1 | Ser403 | DDSTLSEsANQVFLG | phosphorylation up-regulates activity | 12023960 | SIGNOR-262953 |
| mTORC1 | RPS6KB1 | Thr412 | NQVFLGFtYVAPSVL | phosphorylation up-regulates | 15809305 | SIGNOR-217067 |
| mTORC1 | RPS6KB1 | Thr412 | NQVFLGFtYVAPSVL | phosphorylation up-regulates | 17510057 | SIGNOR-217071 |
| MTOR | RPS6KB1 | Ser394 | TRQTPVDsPDDSTLS | phosphorylation up-regulates activity | 23486913 | SIGNOR-201530 |
| PDPK1 | RPS6KB1 | Thr252 | HDGTVTHtFCGTIEY | phosphorylation up-regulates activity | 9445476 | SIGNOR-243338 |
| MTOR | RPS6KB1 | Ser434 | SFEPKIRsPRRFIGS | phosphorylation up-regulates activity | 23486913 | SIGNOR-201534 |
| PHLPP1 | RPS6KB1 | Thr390 | DSKFTRQtPVDSPDD | dephosphorylation down-regulates activity | 21986499 | SIGNOR-237454 |
| ERK1/2 | RPS6KB1 | – | phosphorylation up-regulates activity | 14967450 | SIGNOR-270198 | |
| CDK1 | RPS6KB1 | Thr444 | RFIGSPRtPVSPVKF | phosphorylation up-regulates | 15774499 | SIGNOR-134654 |
| mTORC1 | RPS6KB1 | Thr390 | DSKFTRQtPVDSPDD | phosphorylation up-regulates activity | 11914378 | SIGNOR-255840 |
| PDPK1 | RPS6KB1 | Thr412 | NQVFLGFtYVAPSVL | phosphorylation up-regulates | 9445476 | SIGNOR-55310 |
| MTOR | RPS6KB1 | Thr412 | NQVFLGFtYVAPSVL | phosphorylation up-regulates activity | 12782654 | SIGNOR-101336 |
| MAPK1 | RPS6KB1 | Ser447 | GSPRTPVsPVKFSPG | phosphorylation up-regulates | 21035469 | SIGNOR-169154 |
| Gbeta | RPS6KB1 | – | phosphorylation up-regulates activity | 14967450 | SIGNOR-270103 | |
| MAPK1 | RPS6KB1 | Ser447 | GSPRTPVsPVKFSPG | phosphorylation up-regulates | 19085255 | SIGNOR-182808 |
| MAPK1 | RPS6KB1 | Ser447 | GSPRTPVsPVKFSPG | phosphorylation up-regulates | 7545671 | SIGNOR-28800 |
| MAPK1 | RPS6KB1 | Ser434 | SFEPKIRsPRRFIGS | phosphorylation up-regulates | 21035469 | SIGNOR-169150 |
| MTOR | RPS6KB1 | Thr412 | NQVFLGFtYVAPSVL | phosphorylation up-regulates activity | 10579915 | SIGNOR-72682 |
| MAPK1 | RPS6KB1 | Thr444 | RFIGSPRtPVSPVKF | phosphorylation up-regulates | 11705993 | SIGNOR-111511 |
| MAPK3 | RPS6KB1 | – | phosphorylation up-regulates activity | 14967450 | SIGNOR-121997 | |
| MAPK1 | RPS6KB1 | Ser434 | SFEPKIRsPRRFIGS | phosphorylation up-regulates | 14967450 | SIGNOR-121984 |
| PDPK1 | RPS6KB1 | Thr252 | HDGTVTHtFCGTIEY | phosphorylation up-regulates | 9445476 | SIGNOR-55306 |
| mTORC1 | RPS6KB1 | Thr412 | NQVFLGFtYVAPSVL | phosphorylation up-regulates | 10567431 | SIGNOR-217056 |
| MTOR | RPS6KB1 | Thr412 | NQVFLGFtYVAPSVL | phosphorylation up-regulates activity | 17510057 | SIGNOR-235507 |
| MAPK1 | RPS6KB1 | Thr444 | RFIGSPRtPVSPVKF | phosphorylation up-regulates | 15774499 | SIGNOR-134658 |
| CDK1 | RPS6KB1 | Ser434 | SFEPKIRsPRRFIGS | phosphorylation up-regulates | 12586835 | SIGNOR-98215 |
| MAPK1 | RPS6KB1 | Ser447 | GSPRTPVsPVKFSPG | phosphorylation up-regulates | 14967450 | SIGNOR-121988 |
| MTOR | RPS6KB1 | Ser434 | SFEPKIRsPRRFIGS | phosphorylation up-regulates activity | 12782654 | SIGNOR-101332 |
| MTOR | RPS6KB1 | Thr412 | NQVFLGFtYVAPSVL | phosphorylation up-regulates activity | 10567431 | SIGNOR-72357 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | phosphorylation up-regulates → | RPS6KB1 PThr444 | phosphorylation up-regulates → | RPS6KB1 | 15774499 | SIGNOR-134662 |
| MTOR | phosphorylation up-regulates → | RPS6KB1 PSer394 | phosphorylation up-regulates → | RPS6KB1 | 12782654 | SIGNOR-101328 |
| PDPK1 | phosphorylation up-regulates → | RPS6KB1 PThr412 | phosphorylation up-regulates → | RPS6KB1 | 9445476 | SIGNOR-188911 |
| CDK1 | phosphorylation up-regulates → | RPS6KB1 PSer434 | phosphorylation up-regulates → | RPS6KB1 | 9271440 | SIGNOR-50607 |
| MTOR | phosphorylation up-regulates → | RPS6KB1 PThr412 | phosphorylation up-regulates → | RPS6KB1 | 23486913 | SIGNOR-201538 |
| PHLPP2 | dephosphorylation down-regulates ⊣ | RPS6KB1 PThr390 | dephosphorylation up-regulates → | RPS6KB1 | 21986499 | SIGNOR-248247 |
| CDK1 | phosphorylation up-regulates → | RPS6KB1 PSer394 | phosphorylation up-regulates → | RPS6KB1 | 9271440 | SIGNOR-50603 |
| MTOR | phosphorylation up-regulates → | RPS6KB1 PThr390 | phosphorylation up-regulates → | RPS6KB1 | 11914378 | SIGNOR-255839 |
| PDPK1 | phosphorylation up-regulates → | RPS6KB1 PThr252 | phosphorylation up-regulates → | RPS6KB1 | 19864428 | SIGNOR-188907 |
| MAPK1 | phosphorylation up-regulates → | RPS6KB1 PSer434 | phosphorylation up-regulates → | RPS6KB1 | 7545671 | SIGNOR-28796 |
| NEK6 | phosphorylation up-regulates → | RPS6KB1 PSer53 | phosphorylation up-regulates → | RPS6KB1 | 12023960 | SIGNOR-262952 |
| mTORC1 | phosphorylation up-regulates → | RPS6KB1 PThr412 | phosphorylation up-regulates → | RPS6KB1 | 10579915 | SIGNOR-217060 |
| MAPK1 | phosphorylation up-regulates → | RPS6KB1 PSer434 | phosphorylation up-regulates → | RPS6KB1 | 19085255 | SIGNOR-182804 |
| CDK1 | phosphorylation up-regulates → | RPS6KB1 PThr444 | phosphorylation up-regulates → | RPS6KB1 | 11705993 | SIGNOR-111507 |
| CDK1 | phosphorylation up-regulates → | RPS6KB1 PSer394 | phosphorylation up-regulates → | RPS6KB1 | 12586835 | SIGNOR-98211 |
| MAPK3 | phosphorylation up-regulates → | RPS6KB1 PSer441 | phosphorylation up-regulates → | RPS6KB1 | 15774499 | SIGNOR-111515 |
| NEK6 | phosphorylation up-regulates → | RPS6KB1 PSer403 | phosphorylation up-regulates → | RPS6KB1 | 12023960 | SIGNOR-262953 |
| mTORC1 | phosphorylation up-regulates → | RPS6KB1 PThr412 | phosphorylation up-regulates → | RPS6KB1 | 15809305 | SIGNOR-217067 |
| mTORC1 | phosphorylation up-regulates → | RPS6KB1 PThr412 | phosphorylation up-regulates → | RPS6KB1 | 17510057 | SIGNOR-217071 |
| MTOR | phosphorylation up-regulates → | RPS6KB1 PSer394 | phosphorylation up-regulates → | RPS6KB1 | 23486913 | SIGNOR-201530 |
| PDPK1 | phosphorylation up-regulates → | RPS6KB1 PThr252 | phosphorylation up-regulates → | RPS6KB1 | 9445476 | SIGNOR-243338 |
| MTOR | phosphorylation up-regulates → | RPS6KB1 PSer434 | phosphorylation up-regulates → | RPS6KB1 | 23486913 | SIGNOR-201534 |
| PHLPP1 | dephosphorylation down-regulates ⊣ | RPS6KB1 PThr390 | dephosphorylation up-regulates → | RPS6KB1 | 21986499 | SIGNOR-237454 |
| CDK1 | phosphorylation up-regulates → | RPS6KB1 PThr444 | phosphorylation up-regulates → | RPS6KB1 | 15774499 | SIGNOR-134654 |
| mTORC1 | phosphorylation up-regulates → | RPS6KB1 PThr390 | phosphorylation up-regulates → | RPS6KB1 | 11914378 | SIGNOR-255840 |
| PDPK1 | phosphorylation up-regulates → | RPS6KB1 PThr412 | phosphorylation up-regulates → | RPS6KB1 | 9445476 | SIGNOR-55310 |
| MTOR | phosphorylation up-regulates → | RPS6KB1 PThr412 | phosphorylation up-regulates → | RPS6KB1 | 12782654 | SIGNOR-101336 |
| MAPK1 | phosphorylation up-regulates → | RPS6KB1 PSer447 | phosphorylation up-regulates → | RPS6KB1 | 21035469 | SIGNOR-169154 |
| MAPK1 | phosphorylation up-regulates → | RPS6KB1 PSer447 | phosphorylation up-regulates → | RPS6KB1 | 19085255 | SIGNOR-182808 |
| MAPK1 | phosphorylation up-regulates → | RPS6KB1 PSer447 | phosphorylation up-regulates → | RPS6KB1 | 7545671 | SIGNOR-28800 |
| MAPK1 | phosphorylation up-regulates → | RPS6KB1 PSer434 | phosphorylation up-regulates → | RPS6KB1 | 21035469 | SIGNOR-169150 |
| MTOR | phosphorylation up-regulates → | RPS6KB1 PThr412 | phosphorylation up-regulates → | RPS6KB1 | 10579915 | SIGNOR-72682 |
| MAPK1 | phosphorylation up-regulates → | RPS6KB1 PThr444 | phosphorylation up-regulates → | RPS6KB1 | 11705993 | SIGNOR-111511 |
| MAPK1 | phosphorylation up-regulates → | RPS6KB1 PSer434 | phosphorylation up-regulates → | RPS6KB1 | 14967450 | SIGNOR-121984 |
| PDPK1 | phosphorylation up-regulates → | RPS6KB1 PThr252 | phosphorylation up-regulates → | RPS6KB1 | 9445476 | SIGNOR-55306 |
| mTORC1 | phosphorylation up-regulates → | RPS6KB1 PThr412 | phosphorylation up-regulates → | RPS6KB1 | 10567431 | SIGNOR-217056 |
| MTOR | phosphorylation up-regulates → | RPS6KB1 PThr412 | phosphorylation up-regulates → | RPS6KB1 | 17510057 | SIGNOR-235507 |
| MAPK1 | phosphorylation up-regulates → | RPS6KB1 PThr444 | phosphorylation up-regulates → | RPS6KB1 | 15774499 | SIGNOR-134658 |
| CDK1 | phosphorylation up-regulates → | RPS6KB1 PSer434 | phosphorylation up-regulates → | RPS6KB1 | 12586835 | SIGNOR-98215 |
| MAPK1 | phosphorylation up-regulates → | RPS6KB1 PSer447 | phosphorylation up-regulates → | RPS6KB1 | 14967450 | SIGNOR-121988 |
| MTOR | phosphorylation up-regulates → | RPS6KB1 PSer434 | phosphorylation up-regulates → | RPS6KB1 | 12782654 | SIGNOR-101332 |
| MTOR | phosphorylation up-regulates → | RPS6KB1 PThr412 | phosphorylation up-regulates → | RPS6KB1 | 10567431 | SIGNOR-72357 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK3 | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-134662 |
| MTOR | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-101328 |
| PDPK1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-188911 |
| CDK1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-50607 |
| MTOR | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-201538 |
| PHLPP2 | dephosphorylation → down-regulates activity | RPS6KB1 | SIGNOR-248247 |
| PTEN | dephosphorylation → down-regulates activity | RPS6KB1 | SIGNOR-277080 |
| CDK1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-50603 |
| PPP2CA | dephosphorylation down-regulates | RPS6KB1 | SIGNOR-23575 |
| MTOR | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-255839 |
| PDPK1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-188907 |
| MAPK1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-28796 |
| NEK6 | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-262952 |
| mTORC1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-217060 |
| mTORC1 | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-273843 |
| MAPK1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-182804 |
| CDK1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-111507 |
| CDK1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-98211 |
| MAPK3 | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-111515 |
| NEK6 | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-262953 |
| mTORC1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-217067 |
| mTORC1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-217071 |
| MTOR | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-201530 |
| PDPK1 | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-243338 |
| MTOR | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-201534 |
| PHLPP1 | dephosphorylation → down-regulates activity | RPS6KB1 | SIGNOR-237454 |
| ERK1/2 | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-270198 |
| CDK1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-134654 |
| mTORC1 | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-255840 |
| PDPK1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-55310 |
| MTOR | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-101336 |
| MAPK1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-169154 |
| Gbeta | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-270103 |
| MAPK1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-182808 |
| MAPK1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-28800 |
| MAPK1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-169150 |
| MTOR | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-72682 |
| MAPK1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-111511 |
| MAPK3 | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-121997 |
| MAPK1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-121984 |
| PDPK1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-55306 |
| mTORC1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-217056 |
| MTOR | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-235507 |
| MAPK1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-134658 |
| CDK1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-98215 |
| MAPK1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-121988 |
| MTOR | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-101332 |
| MTOR | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-72357 |