| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | RPS6KB1 | Ser434 | SFEPKIRsPRRFIGS | phosphorylation up-regulates | 21035469 | SIGNOR-169150 |
| MAPK1 | RPS6KB1 | Ser434 | SFEPKIRsPRRFIGS | phosphorylation up-regulates | 14967450 | SIGNOR-121984 |
| CDK1 | RPS6KB1 | Ser434 | SFEPKIRsPRRFIGS | phosphorylation up-regulates | 9271440 | SIGNOR-50607 |
| CDK1 | RPS6KB1 | Ser434 | SFEPKIRsPRRFIGS | phosphorylation up-regulates | 12586835 | SIGNOR-98215 |
| MTOR | RPS6KB1 | Ser434 | SFEPKIRsPRRFIGS | phosphorylation up-regulates activity | 12782654 | SIGNOR-101332 |
| MAPK1 | RPS6KB1 | Ser434 | SFEPKIRsPRRFIGS | phosphorylation up-regulates | 7545671 | SIGNOR-28796 |
| MAPK1 | RPS6KB1 | Ser434 | SFEPKIRsPRRFIGS | phosphorylation up-regulates | 19085255 | SIGNOR-182804 |
| MTOR | RPS6KB1 | Ser434 | SFEPKIRsPRRFIGS | phosphorylation up-regulates activity | 23486913 | SIGNOR-201534 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | RPS6KB1 PSer434 | phosphorylation up-regulates → | RPS6KB1 | 21035469 | SIGNOR-169150 |
| MAPK1 | phosphorylation up-regulates → | RPS6KB1 PSer434 | phosphorylation up-regulates → | RPS6KB1 | 14967450 | SIGNOR-121984 |
| CDK1 | phosphorylation up-regulates → | RPS6KB1 PSer434 | phosphorylation up-regulates → | RPS6KB1 | 9271440 | SIGNOR-50607 |
| CDK1 | phosphorylation up-regulates → | RPS6KB1 PSer434 | phosphorylation up-regulates → | RPS6KB1 | 12586835 | SIGNOR-98215 |
| MTOR | phosphorylation up-regulates → | RPS6KB1 PSer434 | phosphorylation up-regulates → | RPS6KB1 | 12782654 | SIGNOR-101332 |
| MAPK1 | phosphorylation up-regulates → | RPS6KB1 PSer434 | phosphorylation up-regulates → | RPS6KB1 | 7545671 | SIGNOR-28796 |
| MAPK1 | phosphorylation up-regulates → | RPS6KB1 PSer434 | phosphorylation up-regulates → | RPS6KB1 | 19085255 | SIGNOR-182804 |
| MTOR | phosphorylation up-regulates → | RPS6KB1 PSer434 | phosphorylation up-regulates → | RPS6KB1 | 23486913 | SIGNOR-201534 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-169150 |
| MAPK1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-121984 |
| CDK1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-50607 |
| CDK1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-98215 |
| MTOR | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-101332 |
| MAPK1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-28796 |
| MAPK1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-182804 |
| MTOR | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-201534 |
