| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | RPS6KB1 | Thr444 | RFIGSPRtPVSPVKF | phosphorylation up-regulates | 11705993 | SIGNOR-111511 |
| MAPK1 | RPS6KB1 | Thr444 | RFIGSPRtPVSPVKF | phosphorylation up-regulates | 15774499 | SIGNOR-134658 |
| MAPK3 | RPS6KB1 | Thr444 | RFIGSPRtPVSPVKF | phosphorylation up-regulates activity | 15774499 | SIGNOR-134662 |
| CDK1 | RPS6KB1 | Thr444 | RFIGSPRtPVSPVKF | phosphorylation up-regulates | 11705993 | SIGNOR-111507 |
| CDK1 | RPS6KB1 | Thr444 | RFIGSPRtPVSPVKF | phosphorylation up-regulates | 15774499 | SIGNOR-134654 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | RPS6KB1 PThr444 | phosphorylation up-regulates → | RPS6KB1 | 11705993 | SIGNOR-111511 |
| MAPK1 | phosphorylation up-regulates → | RPS6KB1 PThr444 | phosphorylation up-regulates → | RPS6KB1 | 15774499 | SIGNOR-134658 |
| MAPK3 | phosphorylation up-regulates → | RPS6KB1 PThr444 | phosphorylation up-regulates → | RPS6KB1 | 15774499 | SIGNOR-134662 |
| CDK1 | phosphorylation up-regulates → | RPS6KB1 PThr444 | phosphorylation up-regulates → | RPS6KB1 | 11705993 | SIGNOR-111507 |
| CDK1 | phosphorylation up-regulates → | RPS6KB1 PThr444 | phosphorylation up-regulates → | RPS6KB1 | 15774499 | SIGNOR-134654 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-111511 |
| MAPK1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-134658 |
| MAPK3 | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-134662 |
| CDK1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-111507 |
| CDK1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-134654 |
