Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
mTORC1	RPS6KB1	Thr390 View in OncoXplorer	DSKFTRQtPVDSPDD	phosphorylation up-regulates activity	11914378	SIGNOR-255840
PHLPP2	RPS6KB1	Thr390 View in OncoXplorer	DSKFTRQtPVDSPDD	dephosphorylation down-regulates activity	21986499	SIGNOR-248247
MTOR	RPS6KB1	Thr390 View in OncoXplorer	DSKFTRQtPVDSPDD	phosphorylation up-regulates activity	11914378	SIGNOR-255839
PHLPP1	RPS6KB1	Thr390 View in OncoXplorer	DSKFTRQtPVDSPDD	dephosphorylation down-regulates activity	21986499	SIGNOR-237454

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
mTORC1	phosphorylation up-regulates →	RPS6KB1 PThr390	phosphorylation up-regulates →	RPS6KB1	11914378	SIGNOR-255840
PHLPP2	dephosphorylation down-regulates ⊣	RPS6KB1 PThr390	dephosphorylation up-regulates →	RPS6KB1	21986499	SIGNOR-248247
MTOR	phosphorylation up-regulates →	RPS6KB1 PThr390	phosphorylation up-regulates →	RPS6KB1	11914378	SIGNOR-255839
PHLPP1	dephosphorylation down-regulates ⊣	RPS6KB1 PThr390	dephosphorylation up-regulates →	RPS6KB1	21986499	SIGNOR-237454

Regulator	Mechanism/Effect	Target	SIGNOR-ID
mTORC1	phosphorylation → up-regulates activity	RPS6KB1	SIGNOR-255840
PHLPP2	dephosphorylation → down-regulates activity	RPS6KB1	SIGNOR-248247
MTOR	phosphorylation → up-regulates activity	RPS6KB1	SIGNOR-255839
PHLPP1	dephosphorylation → down-regulates activity	RPS6KB1	SIGNOR-237454