Entity Details

Name mTORC1_Thr390
ID P23443
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PHLPP1RPS6KB1Thr390DSKFTRQtPVDSPDDdephosphorylation
down-regulates activity		21986499SIGNOR-237454
mTORC1RPS6KB1Thr390DSKFTRQtPVDSPDDphosphorylation
up-regulates activity		11914378SIGNOR-255840
PHLPP2RPS6KB1Thr390DSKFTRQtPVDSPDDdephosphorylation
down-regulates activity		21986499SIGNOR-248247
MTORRPS6KB1Thr390DSKFTRQtPVDSPDDphosphorylation
up-regulates activity		11914378SIGNOR-255839
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PHLPP1dephosphorylation
down-regulates
⊣
RPS6KB1
PThr390		dephosphorylation
up-regulates
→		RPS6KB121986499SIGNOR-237454
mTORC1phosphorylation
up-regulates
→
RPS6KB1
PThr390		phosphorylation
up-regulates
→		RPS6KB111914378SIGNOR-255840
PHLPP2dephosphorylation
down-regulates
⊣
RPS6KB1
PThr390		dephosphorylation
up-regulates
→		RPS6KB121986499SIGNOR-248247
MTORphosphorylation
up-regulates
→
RPS6KB1
PThr390		phosphorylation
up-regulates
→		RPS6KB111914378SIGNOR-255839
Regulator Mechanism/Effect Target SIGNOR-ID
PHLPP1dephosphorylation
→
down-regulates activity 		RPS6KB1SIGNOR-237454
mTORC1phosphorylation
→
up-regulates activity 		RPS6KB1SIGNOR-255840
PHLPP2dephosphorylation
→
down-regulates activity 		RPS6KB1SIGNOR-248247
MTORphosphorylation
→
up-regulates activity 		RPS6KB1SIGNOR-255839