| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MTOR | RPS6KB1 | Thr412 | NQVFLGFtYVAPSVL | phosphorylation up-regulates activity | 10579915 | SIGNOR-72682 |
| MTOR | RPS6KB1 | Thr412 | NQVFLGFtYVAPSVL | phosphorylation up-regulates activity | 23486913 | SIGNOR-201538 |
| mTORC1 | RPS6KB1 | Thr412 | NQVFLGFtYVAPSVL | phosphorylation up-regulates | 10567431 | SIGNOR-217056 |
| MTOR | RPS6KB1 | Thr412 | NQVFLGFtYVAPSVL | phosphorylation up-regulates activity | 17510057 | SIGNOR-235507 |
| MTOR | RPS6KB1 | Thr412 | NQVFLGFtYVAPSVL | phosphorylation up-regulates activity | 10567431 | SIGNOR-72357 |
| PDPK1 | RPS6KB1 | Thr412 | NQVFLGFtYVAPSVL | phosphorylation up-regulates | 9445476 | SIGNOR-188911 |
| mTORC1 | RPS6KB1 | Thr412 | NQVFLGFtYVAPSVL | phosphorylation up-regulates | 10579915 | SIGNOR-217060 |
| mTORC1 | RPS6KB1 | Thr412 | NQVFLGFtYVAPSVL | phosphorylation up-regulates | 15809305 | SIGNOR-217067 |
| mTORC1 | RPS6KB1 | Thr412 | NQVFLGFtYVAPSVL | phosphorylation up-regulates | 17510057 | SIGNOR-217071 |
| PDPK1 | RPS6KB1 | Thr412 | NQVFLGFtYVAPSVL | phosphorylation up-regulates | 9445476 | SIGNOR-55310 |
| MTOR | RPS6KB1 | Thr412 | NQVFLGFtYVAPSVL | phosphorylation up-regulates activity | 12782654 | SIGNOR-101336 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MTOR | phosphorylation up-regulates → | RPS6KB1 PThr412 | phosphorylation up-regulates → | RPS6KB1 | 10579915 | SIGNOR-72682 |
| MTOR | phosphorylation up-regulates → | RPS6KB1 PThr412 | phosphorylation up-regulates → | RPS6KB1 | 23486913 | SIGNOR-201538 |
| mTORC1 | phosphorylation up-regulates → | RPS6KB1 PThr412 | phosphorylation up-regulates → | RPS6KB1 | 10567431 | SIGNOR-217056 |
| MTOR | phosphorylation up-regulates → | RPS6KB1 PThr412 | phosphorylation up-regulates → | RPS6KB1 | 17510057 | SIGNOR-235507 |
| MTOR | phosphorylation up-regulates → | RPS6KB1 PThr412 | phosphorylation up-regulates → | RPS6KB1 | 10567431 | SIGNOR-72357 |
| PDPK1 | phosphorylation up-regulates → | RPS6KB1 PThr412 | phosphorylation up-regulates → | RPS6KB1 | 9445476 | SIGNOR-188911 |
| mTORC1 | phosphorylation up-regulates → | RPS6KB1 PThr412 | phosphorylation up-regulates → | RPS6KB1 | 10579915 | SIGNOR-217060 |
| mTORC1 | phosphorylation up-regulates → | RPS6KB1 PThr412 | phosphorylation up-regulates → | RPS6KB1 | 15809305 | SIGNOR-217067 |
| mTORC1 | phosphorylation up-regulates → | RPS6KB1 PThr412 | phosphorylation up-regulates → | RPS6KB1 | 17510057 | SIGNOR-217071 |
| PDPK1 | phosphorylation up-regulates → | RPS6KB1 PThr412 | phosphorylation up-regulates → | RPS6KB1 | 9445476 | SIGNOR-55310 |
| MTOR | phosphorylation up-regulates → | RPS6KB1 PThr412 | phosphorylation up-regulates → | RPS6KB1 | 12782654 | SIGNOR-101336 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MTOR | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-72682 |
| MTOR | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-201538 |
| mTORC1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-217056 |
| MTOR | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-235507 |
| MTOR | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-72357 |
| PDPK1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-188911 |
| mTORC1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-217060 |
| mTORC1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-217067 |
| mTORC1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-217071 |
| PDPK1 | phosphorylation → up-regulates | RPS6KB1 | SIGNOR-55310 |
| MTOR | phosphorylation → up-regulates activity | RPS6KB1 | SIGNOR-101336 |
