| Name | JAK1 |
| ID | P23458 |
| Role | kinase |
| Enzymatic Domains |
FERM 34-420 PROSITE-ProRule
SH2 439-544 PROSITE-ProRule
Protein kinase 1 583-855 PROSITE-ProRule
Protein kinase 2 875-1153 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JAK1 | IL2RB | Tyr364 | SCFTNQGyFFFHLPD | phosphorylation up-regulates activity | 8700888 | SIGNOR-251342 |
| JAK1 | IL2RB | Tyr418 | LSGEDDAyCTFPSRD | phosphorylation up-regulates activity | 8700888 | SIGNOR-251340 |
| JAK1 | IL2RB | Tyr536 | LPLNTDAyLSLQELQ | phosphorylation up-regulates activity | 8700888 | SIGNOR-251341 |
| JAK1 | IFNGR1 | Tyr457 | KAPTSFGyDKPHVLV | phosphorylation up-regulates | 7615558 | SIGNOR-29866 |
| JAK1 | IFNGR1 | – | phosphorylation up-regulates activity | 19041276 | SIGNOR-249488 | |
| JAK1 | TYK2 | Tyr1054 | AVPEGHEyYRVREDG | phosphorylation up-regulates | 30029643 | SIGNOR-256221 |
| JAK1 | TYK2 | Tyr1054 | AVPEGHEyYRVREDG | phosphorylation up-regulates | 8702790 | SIGNOR-43080 |
| JAK1 | TYK2 | Tyr1055 | VPEGHEYyRVREDGD | phosphorylation up-regulates | 8702790 | SIGNOR-43084 |
| JAK1 | IRS1 | – | phosphorylation up-regulates activity | 9305869 | SIGNOR-251343 | |
| JAK1 | IFNGR2 | – | phosphorylation up-regulates activity | 19041276 | SIGNOR-249491 | |
| JAK1 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 19723038 | SIGNOR-187775 |
| JAK1 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 26260587 | SIGNOR-249546 |
| JAK1 | STAT3 | – | phosphorylation up-regulates activity | 26260587 | SIGNOR-253590 | |
| JAK1 | STAT1 | – | phosphorylation up-regulates | 21576360 | SIGNOR-256247 | |
| JAK1 | STAT1 | Tyr701 | DGPKGTGyIKTELIS | phosphorylation up-regulates activity | 11823427 | SIGNOR-236373 |
| JAK1 | STAT1 | Tyr701 | DGPKGTGyIKTELIS | phosphorylation up-regulates activity | 7657660 | SIGNOR-30905 |
| JAK1 | STAT1 | – | phosphorylation up-regulates activity | 9020188 | SIGNOR-236239 | |
| JAK1 | STAT6 | – | phosphorylation up-regulates activity | 23124025 | SIGNOR-249531 | |
| JAK1 | STAT6 | – | phosphorylation up-regulates activity | 9852261 | SIGNOR-62582 | |
| JAK1 | JAK3 | – | phosphorylation up-regulates | 17259970 | SIGNOR-152914 | |
| JAK1 | STAT2 | Tyr690 | NLQERRKyLKHRLIV | phosphorylation up-regulates activity | 9020188 | SIGNOR-251344 |
| JAK1 | STAT2 | – | phosphorylation up-regulates activity | 9020188 | SIGNOR-88285 | |
| JAK1 | PTPN11 | Tyr304 | PNEPVSDyINANIIM | phosphorylation up-regulates activity | 8995399 | SIGNOR-236282 |
| JAK1 | PTPN11 | Tyr327 | NSKPKKSyIATQGCL | phosphorylation up-regulates activity | 8995399 | SIGNOR-236274 |
| JAK1 | RIPK1 | Tyr384 | KLQDEANyHLYGSRM | phosphorylation up-regulates activity | 36329033 | SIGNOR-278948 |
| JAK1 | IL10RA | Tyr446 | AAVAFQGyLRQTRCA | phosphorylation up-regulates activity | 10433356 | SIGNOR-251338 |
| JAK1 | IL10RA | Tyr496 | PPALAKGyLKQDPLE | phosphorylation up-regulates activity | 10433356 | SIGNOR-251339 |
| JAK1 | EIF2AK3 | Tyr585 | NDIKNSGyISRYLTD | phosphorylation up-regulates activity | 25113558 | SIGNOR-276676 |
| JAK1 | EIF2AK3 | Tyr619 | NKVDDCNyAIKRIRL | phosphorylation up-regulates activity | 25113558 | SIGNOR-276677 |
| JAK1 | SNX8 | Tyr126 | MLLHKFPyRMVPALP | phosphorylation up-regulates activity | 29180417 | SIGNOR-273645 |
| JAK1 | SNX8 | Tyr95 | LFLKHVEyEVSSQRF | phosphorylation up-regulates activity | 29180417 | SIGNOR-273647 |
| JAK1 | ISGF3 complex | – | phosphorylation up-regulates activity | 15120645 | SIGNOR-260149 | |
| JAK1 | IFNGR2/INFGR1 | – | phosphorylation up-regulates activity | 19041276 | SIGNOR-249492 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JAK1 | phosphorylation up-regulates → | IL2RB PTyr364 | phosphorylation up-regulates → | IL2RB | 8700888 | SIGNOR-251342 |
| JAK1 | phosphorylation up-regulates → | IL2RB PTyr418 | phosphorylation up-regulates → | IL2RB | 8700888 | SIGNOR-251340 |
| JAK1 | phosphorylation up-regulates → | IL2RB PTyr536 | phosphorylation up-regulates → | IL2RB | 8700888 | SIGNOR-251341 |
| JAK1 | phosphorylation up-regulates → | IFNGR1 PTyr457 | phosphorylation up-regulates → | IFNGR1 | 7615558 | SIGNOR-29866 |
| JAK1 | phosphorylation up-regulates → | TYK2 PTyr1054 | phosphorylation up-regulates → | TYK2 | 30029643 | SIGNOR-256221 |
| JAK1 | phosphorylation up-regulates → | TYK2 PTyr1054 | phosphorylation up-regulates → | TYK2 | 8702790 | SIGNOR-43080 |
| JAK1 | phosphorylation up-regulates → | TYK2 PTyr1055 | phosphorylation up-regulates → | TYK2 | 8702790 | SIGNOR-43084 |
| JAK1 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 19723038 | SIGNOR-187775 |
| JAK1 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 26260587 | SIGNOR-249546 |
| JAK1 | phosphorylation up-regulates → | STAT1 PTyr701 | phosphorylation up-regulates → | STAT1 | 11823427 | SIGNOR-236373 |
| JAK1 | phosphorylation up-regulates → | STAT1 PTyr701 | phosphorylation up-regulates → | STAT1 | 7657660 | SIGNOR-30905 |
| JAK1 | phosphorylation up-regulates → | STAT2 PTyr690 | phosphorylation up-regulates → | STAT2 | 9020188 | SIGNOR-251344 |
| JAK1 | phosphorylation up-regulates → | PTPN11 PTyr304 | phosphorylation up-regulates → | PTPN11 | 8995399 | SIGNOR-236282 |
| JAK1 | phosphorylation up-regulates → | PTPN11 PTyr327 | phosphorylation up-regulates → | PTPN11 | 8995399 | SIGNOR-236274 |
| JAK1 | phosphorylation up-regulates → | RIPK1 PTyr384 | phosphorylation up-regulates → | RIPK1 | 36329033 | SIGNOR-278948 |
| JAK1 | phosphorylation up-regulates → | IL10RA PTyr446 | phosphorylation up-regulates → | IL10RA | 10433356 | SIGNOR-251338 |
| JAK1 | phosphorylation up-regulates → | IL10RA PTyr496 | phosphorylation up-regulates → | IL10RA | 10433356 | SIGNOR-251339 |
| JAK1 | phosphorylation up-regulates → | EIF2AK3 PTyr585 | phosphorylation up-regulates → | EIF2AK3 | 25113558 | SIGNOR-276676 |
| JAK1 | phosphorylation up-regulates → | EIF2AK3 PTyr619 | phosphorylation up-regulates → | EIF2AK3 | 25113558 | SIGNOR-276677 |
| JAK1 | phosphorylation up-regulates → | SNX8 PTyr126 | phosphorylation up-regulates → | SNX8 | 29180417 | SIGNOR-273645 |
| JAK1 | phosphorylation up-regulates → | SNX8 PTyr95 | phosphorylation up-regulates → | SNX8 | 29180417 | SIGNOR-273647 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| JAK1 | phosphorylation → up-regulates activity | IL2RB | SIGNOR-251342 |
| JAK1 | phosphorylation → up-regulates activity | IL2RB | SIGNOR-251340 |
| JAK1 | phosphorylation → up-regulates activity | IL2RB | SIGNOR-251341 |
| JAK1 | phosphorylation → up-regulates | IFNGR1 | SIGNOR-29866 |
| JAK1 | phosphorylation → up-regulates activity | IFNGR1 | SIGNOR-249488 |
| JAK1 | phosphorylation → up-regulates | TYK2 | SIGNOR-256221 |
| JAK1 | phosphorylation → up-regulates | TYK2 | SIGNOR-43080 |
| JAK1 | phosphorylation → up-regulates | TYK2 | SIGNOR-43084 |
| JAK1 | phosphorylation → up-regulates activity | IRS1 | SIGNOR-251343 |
| JAK1 | phosphorylation → up-regulates activity | IFNGR2 | SIGNOR-249491 |
| JAK1 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-187775 |
| JAK1 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-249546 |
| JAK1 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-253590 |
| JAK1 | phosphorylation → up-regulates | STAT1 | SIGNOR-256247 |
| JAK1 | phosphorylation → up-regulates activity | STAT1 | SIGNOR-236373 |
| JAK1 | phosphorylation → up-regulates activity | STAT1 | SIGNOR-30905 |
| JAK1 | phosphorylation → up-regulates activity | STAT1 | SIGNOR-236239 |
| JAK1 | phosphorylation → up-regulates activity | STAT6 | SIGNOR-249531 |
| JAK1 | phosphorylation → up-regulates activity | STAT6 | SIGNOR-62582 |
| JAK1 | phosphorylation → up-regulates | JAK3 | SIGNOR-152914 |
| JAK1 | phosphorylation → up-regulates activity | STAT2 | SIGNOR-251344 |
| JAK1 | phosphorylation → up-regulates activity | STAT2 | SIGNOR-88285 |
| JAK1 | phosphorylation → up-regulates activity | PTPN11 | SIGNOR-236282 |
| JAK1 | phosphorylation → up-regulates activity | PTPN11 | SIGNOR-236274 |
| JAK1 | phosphorylation → up-regulates activity | RIPK1 | SIGNOR-278948 |
| JAK1 | phosphorylation → up-regulates activity | IL10RA | SIGNOR-251338 |
| JAK1 | phosphorylation → up-regulates activity | IL10RA | SIGNOR-251339 |
| JAK1 | phosphorylation → up-regulates activity | EIF2AK3 | SIGNOR-276676 |
| JAK1 | phosphorylation → up-regulates activity | EIF2AK3 | SIGNOR-276677 |
| JAK1 | phosphorylation → up-regulates activity | SNX8 | SIGNOR-273645 |
| JAK1 | phosphorylation → up-regulates activity | SNX8 | SIGNOR-273647 |
| JAK1 | phosphorylation → up-regulates activity | ISGF3 complex | SIGNOR-260149 |
| JAK1 | phosphorylation → up-regulates activity | IFNGR2/INFGR1 | SIGNOR-249492 |