| + |
JAK3 | up-regulates activity 
phosphorylation
|
JAK1 |
0.532 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251363 |
Tyr1034 |
AIETDKEyYTVKDDR |
in vitro |
|
| pmid |
sentence |
| 12559972 |
Phosphorylation by recombinant JAK3 of a peptide substrate corresponding to the JAK1 activation loop (KAIETDKEYYTVKD) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251364 |
Tyr1035 |
IETDKEYyTVKDDRD |
in vitro |
|
| pmid |
sentence |
| 12559972 |
Phosphorylation by recombinant JAK3 of a peptide substrate corresponding to the JAK1 activation loop (KAIETDKEYYTVKD) |
|
| Publications: |
2 |
Organism: |
In Vitro |
| + |
PTPRC | down-regulates activity 
dephosphorylation
|
JAK1 |
0.456 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248355 |
Tyr1034 |
AIETDKEyYTVKDDR |
Mus musculus |
|
| pmid |
sentence |
| 11201744 |
CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling|these results show that CD45 dephosphorylates functionally important tyrosine residues. It should be noted that, as with our phosphatase assays in vitro, Tyr 1022 and Tyr 1023 of JAK1, Tyr 1007 and Tyr 1008 of JAK2, and Tyr 1054 and Tyr 1055 of Tyk2 are indeed hyperphosphorylated in cd45-deficient cells |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248356 |
Tyr1035 |
IETDKEYyTVKDDRD |
Mus musculus |
|
| pmid |
sentence |
| 11201744 |
CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling|these results show that CD45 dephosphorylates functionally important tyrosine residues. It should be noted that, as with our phosphatase assays in vitro, Tyr 1022 and Tyr 1023 of JAK1, Tyr 1007 and Tyr 1008 of JAK2, and Tyr 1054 and Tyr 1055 of Tyk2 are indeed hyperphosphorylated in cd45-deficient cells |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| + |
PTPN2 | down-regulates activity
dephosphorylation
|
JAK1 |
0.766 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248395 |
Tyr1034 |
AIETDKEyYTVKDDR |
Mus musculus |
|
| pmid |
sentence |
| 11909529 |
The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3|We have identified JAK1 and JAK3 as physiological substrates of TCPTP.| Using a site-specific antibody directed against the activation loop phosphotyrosines in JAK1 (pY1022/pY1023), we found that these sites were in fact dephosphorylated by TCPTP |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248396 |
Tyr1035 |
IETDKEYyTVKDDRD |
Mus musculus |
|
| pmid |
sentence |
| 11909529 |
The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3|We have identified JAK1 and JAK3 as physiological substrates of TCPTP.| Using a site-specific antibody directed against the activation loop phosphotyrosines in JAK1 (pY1022/pY1023), we found that these sites were in fact dephosphorylated by TCPTP |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134620 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15780598 |
Upon ligand binding, IL-2R , IL-6R or LeptinR , IFN-_R , IFN-_R and PRLR or growth hormone (GH) receptor associated JAKs become activated. These JAKs mediate phosphorylation of specific tyrosine residues and recruit STATs. Activated STATs are released from the receptor and translocate to the nucleus. PTP1B dephosphorylates JAK2, TYK2 and STAT5 . The 45-kDa form of TC-PTP was shown to dephosphorylate JAK1 and JAK3 as well as STAT1, STAT3 and STAT5. |
|
| Publications: |
3 |
Organism: |
Mus Musculus, Homo Sapiens |
| + |
JAK1 | up-regulates
phosphorylation
|
TYK2 |
0.522 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-43080 |
Tyr1054 |
AVPEGHEyYRVREDG |
Homo sapiens |
|
| pmid |
sentence |
| 8702790 |
These results indicate that tyk2 is activated by phosphorylation on tyr-1054 and/or tyr-1055 and that this phosphorylation requires another kinase, most likely jak1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256221 |
Tyr1054 |
AVPEGHEyYRVREDG |
Homo sapiens |
Keratinocyte |
| pmid |
sentence |
| 30029643 |
Since Jak-STAT pathway primarily activated in IL-15-me- diated cell proliferation, we tested whether it is also participates in IL-15-mediated proliferation of FAPs. Interestingly, we found the expression of phospho-Jak3 and phospho-Tyk2, as well as their downstream, phospho- STAT3 and phospho-STAT5, was significantly upregulated |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-43084 |
Tyr1055 |
VPEGHEYyRVREDGD |
Homo sapiens |
|
| pmid |
sentence |
| 8702790 |
These results indicate that tyk2 is activated by phosphorylation on tyr-1054 and/or tyr-1055 and that this phosphorylation requires another kinase, most likely jak1. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, EBV infection, Inflammosome Activation, SARS-CoV INFLAMMATORY RESPONSE |
| + |
JAK1 | up-regulates activity
phosphorylation
|
SNX8 |
0.344 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273645 |
Tyr126 |
MLLHKFPyRMVPALP |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 29180417 |
IFNγ induced JAK1-mediated phosphorylation of SNX8 at Tyr95 and Tyr126, which promoted the recruitment of IKKβ to the JAK1 complex. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273647 |
Tyr95 |
LFLKHVEyEVSSQRF |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 29180417 |
IFNγ induced JAK1-mediated phosphorylation of SNX8 at Tyr95 and Tyr126, which promoted the recruitment of IKKβ to the JAK1 complex. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
JAK1 | up-regulates activity
phosphorylation
|
PTPN11 |
0.767 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236282 |
Tyr304 |
PNEPVSDyINANIIM |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 8995399 |
Tyrosine residues 304 and 327 in shp-2 are phosphorylated by jaks, and phosphorylated shp-2 can associate with the downstream adapter protein grb2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236274 |
Tyr327 |
NSKPKKSyIATQGCL |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 8995399 |
Tyrosine residues 304 and 327 in shp-2 are phosphorylated by jaks, and phosphorylated shp-2 can associate with the downstream adapter protein grb2 |
|
| Publications: |
2 |
Organism: |
Chlorocebus Aethiops |
| + |
JAK1 | up-regulates activity
phosphorylation
|
IL2RB |
0.629 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251342 |
Tyr364 |
SCFTNQGyFFFHLPD |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 8700888 |
In COS-7 cells, overexpression of Jak1 augmented phosphorylation of Y338 as well as Y392 and Y510. Y392 and Y510 were critical for IL-2-induced activation of signal transducers and activators of transcription (STAT proteins), Y338 was required for Shc-IL-2Rbeta association and for IL-2-induced tyrosine phosphorylation of Shc. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251340 |
Tyr418 |
LSGEDDAyCTFPSRD |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 8700888 |
In COS-7 cells, overexpression of Jak1 augmented phosphorylation of Y338 as well as Y392 and Y510. Y392 and Y510 were critical for IL-2-induced activation of signal transducers and activators of transcription (STAT proteins), Y338 was required for Shc-IL-2Rbeta association and for IL-2-induced tyrosine phosphorylation of Shc. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251341 |
Tyr536 |
LPLNTDAyLSLQELQ |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 8700888 |
In COS-7 cells, overexpression of Jak1 augmented phosphorylation of Y338 as well as Y392 and Y510. Y392 and Y510 were critical for IL-2-induced activation of signal transducers and activators of transcription (STAT proteins), Y338 was required for Shc-IL-2Rbeta association and for IL-2-induced tyrosine phosphorylation of Shc. |
|
| Publications: |
3 |
Organism: |
Chlorocebus Aethiops |
| + |
JAK1 | up-regulates activity
phosphorylation
|
IL10RA |
0.808 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251338 |
Tyr446 |
AAVAFQGyLRQTRCA |
|
|
| pmid |
sentence |
| 10433356 |
Binding of IL-10 to the extracellular domain of IL-10R1 activates phosphorylation of the receptor-associated Janus tyrosine kinases, JAK1 and Tyk2. These kinases then phosphorylate specific tyrosine residues (Y446 and Y496) on the intracellular domain of the IL-10R1 chain. Once phosphorylated, these tyrosine residues (and their flanking peptide sequences) serve as temporary docking sites for the latent transcription factor, STAT3 (signal transducer and activator of transcription-3). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251339 |
Tyr496 |
PPALAKGyLKQDPLE |
|
|
| pmid |
sentence |
| 10433356 |
Binding of IL-10 to the extracellular domain of IL-10R1 activates phosphorylation of the receptor-associated Janus tyrosine kinases, JAK1 and Tyk2. These kinases then phosphorylate specific tyrosine residues (Y446 and Y496) on the intracellular domain of the IL-10R1 chain. Once phosphorylated, these tyrosine residues (and their flanking peptide sequences) serve as temporary docking sites for the latent transcription factor, STAT3 (signal transducer and activator of transcription-3). |
|
| Publications: |
2 |
| Pathways: | Multiple sclerosis, SARS-CoV CYTOKINE STORM |
| + |
JAK1 | up-regulates
phosphorylation
|
IFNGR1 |
0.702 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-29866 |
Tyr457 |
KAPTSFGyDKPHVLV |
Homo sapiens |
|
| pmid |
sentence |
| 7615558 |
Interferon gamma activation of stat1alpha requires both jak1 and jak2 as well as tyrosine phosphorylation of the alpha chain of the ifngamma receptor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JAK1 | up-regulates activity
phosphorylation
|
EIF2AK3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276676 |
Tyr585 |
NDIKNSGyISRYLTD |
Mus musculus |
Astrocyte |
| pmid |
sentence |
| 25113558 |
JAK1 interacts with and phosphorylates PERK. PERK-dependent activation of JAK1 and STAT3 contributes to endoplasmic reticulum stress-induced inflammation. Similarly, PERK is associated with and phosphorylated by JAK1 at Y585 and Y619 (and possibly other JAKs) during ER stress, resulting in PERK- and JAK1-dependent activation of STAT3. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276677 |
Tyr619 |
NKVDDCNyAIKRIRL |
Mus musculus |
Astrocyte |
| pmid |
sentence |
| 25113558 |
JAK1 interacts with and phosphorylates PERK. PERK-dependent activation of JAK1 and STAT3 contributes to endoplasmic reticulum stress-induced inflammation. Similarly, PERK is associated with and phosphorylated by JAK1 at Y585 and Y619 (and possibly other JAKs) during ER stress, resulting in PERK- and JAK1-dependent activation of STAT3. |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| Pathways: | COVID-19 Causal Network |
| + |
JAK1 | up-regulates activity
phosphorylation
|
STAT2 |
0.768 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251344 |
Tyr690 |
NLQERRKyLKHRLIV |
|
|
| pmid |
sentence |
| 9020188 |
STAT2 plays a pivotal role in IFN-a signaling. It is recruited to the activated receptor first and, after phosphorylation by JAK kinases on tyrosine 690, provides a docking site for the SH2 domain of STAT1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-88285 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9020188 |
The stat1 and stat2 proteins are present in the cytoplasm of untreated cells;upon stimulation with ifn-?, They become rapidly activated by tyrosine phosphorylation at a single site catalyzed by receptor associated jak (janus) kinases. |
|
| Publications: |
2 |
Organism: |
, Homo Sapiens |
| + |
JAK1 | up-regulates activity
phosphorylation
|
STAT1 |
0.79 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-30905 |
Tyr701 |
DGPKGTGyIKTELIS |
in vitro |
|
| pmid |
sentence |
| 7657660 |
Stat1 was phosphorylated at tyr 701 in jak immune complex kinase reaction. The stat1 and stat2 proteins are present in the cytoplasm of untreated cells;upon stimulation with ifn-g, They become rapidly activated by tyrosine phosphorylation at a single site catalyzed by receptor associated jak (janus) kinases. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236373 |
Tyr701 |
DGPKGTGyIKTELIS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11823427 |
The central event in cytokine_dependent transcriptional regulation is phosphorylation of STATs on a single tyrosine residue at their C_terminus (Darnell, 1997b). The reaction is catalyzed by cytokine receptor_associated tyrosine kinases of the Janus type (Jak) at the cell membrane and triggers the homo_ and heterodimerization of STAT molecules via reciprocal phosphotyrosineSH2 domain interactions |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236239 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 9020188 |
The stat1 and stat2 proteins are present in the cytoplasm of untreated cells;upon stimulation with ifn-g they become rapidly activated by tyrosine phosphorylation at a single site catalyzed by receptor associated jak (janus) kinases. |
|
| Publications: |
3 |
Organism: |
In Vitro, Homo Sapiens |
| Pathways: | EBV infection, SARS-CoV CYTOKINE STORM |
| + |
JAK1 | up-regulates activity
phosphorylation, binding
|
STAT3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-187775 |
Tyr705 |
DPGSAAPyLKTKFIC |
Homo sapiens |
|
| pmid |
sentence |
| 19723038 |
The activation of stat-3 is regulated by phosphorylation of tyrosine 705 by receptor and nonreceptor protein tyrosine kinases. These include epidermal growth factor receptor (egfr) kinase, src, janus-activated kinases (jak), and extracellular signal-regulated kinase (erk). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249546 |
Tyr705 |
DPGSAAPyLKTKFIC |
Mus musculus |
|
| pmid |
sentence |
| 26260587 |
IL10R2 recruits cytoplasmic protein Jak1 followed by phosphorylation of tyrosine at position 705 in the STAT3 (705Y-STAT3) molecule. Phosphorylated STAT3 forms a homodimer, which is then translocated to the nucleus to facilitate transcriptional regulation of target genes. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236369 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24710148 |
The binding of lif to the lifr induces its heterodimerization with gp130. The formation of this complex results in the activation of the receptor-associated janus kinases (jaks), in the phosphorylation of receptor docking sites, and finally in the recruitment of src homology-2 (sh2) domain containing proteins such as stat3 (signal transducer and activator of transcription 3). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253590 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26260587 |
IL10R2 recruits cytoplasmic protein Jak1 followed by phosphorylation of tyrosine at position 705 in the STAT3 (705Y-STAT3) molecule. Phosphorylated STAT3 forms a homodimer, which is then translocated to the nucleus to facilitate transcriptional regulation of target genes. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens, Mus Musculus |
| Pathways: | EBV infection, IL6 Signaling, Multiple sclerosis, SARS-CoV CYTOKINE STORM |
| + |
IL15RA | up-regulates
|
JAK1 |
0.459 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256227 |
|
|
|
T-lymphocyte |
| pmid |
sentence |
| 30029643 |
Since Jak-STAT pathway primarily activated in IL-15-me- diated cell proliferation, we tested whether it is also participates in IL-15-mediated proliferation of FAPs. Interestingly, we found the expression of phospho-Jak3 and phospho-Tyk2, as well as their downstream, phospho- STAT3 and phospho-STAT5, was significantly upregulated |
|
| Publications: |
1 |
| + |
EGFR | up-regulates activity 
|
JAK1 |
0.628 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235655 |
|
|
Mus musculus |
Keratinocyte |
| pmid |
sentence |
| 15284024 |
Two possibilities for STAT activation exist: a janus kinase (JAK)-dependent and a JAK-independent mechanism. Herein, we demonstrate that EGFR overexpression in primary esophageal keratinocytes activates STAT in a JAK-dependent fashion |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | COVID-19 Causal Network |
| + |
IL20RA | up-regulates
binding
|
JAK1 |
0.483 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-124486 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15120645 |
Each r1-type chain (il-10r1, il-20r1, il-22r1, ifn-_r1 and ifn-_r1) is associated with jak1 tyrosine kinase and mediates recruitment of a variety of signaling molecules after being phosphorylated on its intracellular domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL10RA | up-regulates activity
binding,
|
JAK1 |
0.808 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-68010 |
|
|
Homo sapiens |
Macrophage, B-lymphocyte |
| pmid |
sentence |
| 10347215 |
Specifically, il-10 effects the activation of jak1 (associated with the il-10 receptor alpha Chain) and tyk2 (associated with the il-10 receptor beta Chain) and induces the activation of stat1, stat3, and, in some cells, stat5. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253589 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 26260587 |
IL10R2 recruits cytoplasmic protein Jak1 followed by phosphorylation of tyrosine at position 705 in the STAT3 (705Y-STAT3) molecule. Phosphorylated STAT3 forms a homodimer, which is then translocated to the nucleus to facilitate transcriptional regulation of target genes. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Multiple sclerosis, SARS-CoV CYTOKINE STORM |
| + |
JAK1 | up-regulates activity
phosphorylation
|
IFNGR2/INFGR1 |
0.681 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249492 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 19041276 |
The activation of this signaling pathway involves the binding of IFN-g to two IFN-g receptor (IFN-gR) subunits, made up of respective IFNgR1:IFNgR2 pairs, which dimerize upon IFN-g binding to form the IFN-gR complex. Two JAKs, JAK1and JAK2,which bind to each IFN-gR subunits, respectively through their N-terminal domains, both become activated by tyrosine phosphorylation in a JAK2-dependent process. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection, SARS-CoV CYTOKINE STORM |
| + |
JAK3 | up-regulates
phosphorylation
|
JAK1 |
0.532 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152917 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 17259970 |
Il-7r signalling is initiated when il-7 crosslinks the extracellular domains of il-7ralpha and gammac, bringing together jak1 and jak3, which mutually phosphorylate each other, increasing their kinase activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL6ST | up-regulates
binding,
|
JAK1 |
0.674 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-204841 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24710148 |
The binding of lif to the lifr induces its heterodimerization with gp130. The formation of this complex results in the activation of the receptor-associated janus kinases (jaks), in the phosphorylation of receptor docking sites, and finally in the recruitment of src homology-2 (sh2) domain containing proteins such as stat3 (signal transducer and activator of transcription 3). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-202036 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23663276 |
Il-6 family members typically signal through the common gp130 receptor, with the janus kinase/signal transducer and activator of transcription (jak/stat) pathway being the major intracellular mediator of their effects. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| Pathways: | IL6 Signaling, Multiple sclerosis, SARS-CoV CYTOKINE STORM |
| + |
JAK1 | up-regulates activity
phosphorylation
|
ISGF3 complex |
0.725 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260149 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15120645 |
Despite signaling through distinct receptor complexes, type I IFNs and IFN-lambda activate similar signaling events and biological activities, consistent with their common ability to mediate an antiviral state in cells (Fig. 6). In both cases, receptor engagement leads via the activation of the Jak kinases Jak1 and Tyk2 to the activation of the IFN-stimulated gene factor 3 (ISGF3) transcription complex, composed of latent transcriptional factors of the Signal Transducers and Activators of Transcription (STAT) family, Stat1 and Stat2, and of the interferon regulatory factor (IRF) IRF9 (ISGF3g or p48). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Inflammosome Activation, SARS-CoV CYTOKINE STORM, SARS-CoV INFLAMMATORY RESPONSE |
| + |
IL22RA1 | up-regulates
binding
|
JAK1 |
0.521 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-124489 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15120645 |
Each r1-type chain (il-10r1, il-20r1, il-22r1, ifn-_r1 and ifn-_r1) is associated with jak1 tyrosine kinase and mediates recruitment of a variety of signaling molecules after being phosphorylated on its intracellular domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
2-[1-ethylsulfonyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1-pyrazolyl]-3-azetidinyl]acetonitrile | down-regulates activity
chemical inhibition
|
JAK1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-257833 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20363976 |
INCB028050 is a selective orally bioavailable JAK1/JAK2 inhibitor with nanomolar potency against JAK1 (5.9 nM) and JAK2 (5.7 nM). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPRC | up-regulates
dephosphorylation
|
JAK1 |
0.456 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-87154 |
|
|
Homo sapiens |
B-lymphocyte, RAMOS Cell |
| pmid |
sentence |
| 11994288 |
These negative regulatory effects on ig class switching were concomitant with the ability of cd45 to dephosphorylate the induced phosphorylation of jak1, jak3, |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL21R | up-regulates
binding
|
JAK1 |
0.626 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-90266 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 12093291 |
Retroviral-mediated transduction of wild-type gamma c into xscid jt cells restored function to the il-21r, as shown by il-21-induced tyrosine phosphorylation of jak1 and jak3, and downstream activation of stat5 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
N-(cyanomethyl)-4-[2-[4-(4-morpholinyl)anilino]-4-pyrimidinyl]benzamide | down-regulates
chemical inhibition
|
JAK1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-191244 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ruxolitinib | down-regulates activity
chemical inhibition
|
JAK1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258276 |
|
|
in vitro |
|
| pmid |
sentence |
| 22037378 |
Our data set represents the most detailed comprehensive assessment of the reactivity of known and clinical kinase inhibitors across the kinome published to date. | The data also show that for at least 15 of the 27 kinases that are the primary, intended targets for the compounds tested and that are represented in the assay panel, selective inhibitors, as assessed by both absolute selectivity across the kinome and selectivity relative to the primary target, are among the 72 tested here. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
IL2RB | up-regulates
binding
|
JAK1 |
0.629 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-204972 |
|
|
Homo sapiens |
T-lymphocyte, Leukemia Cell, Lymphoma Cell |
| pmid |
sentence |
| 24737791 |
In lymphocytes, binding of il-15 to the il-2/15rbg heterodimer induces jak1 activation that subsequently phosphorylates stat3 via the b-chain and jak3/stat5 activation via its g-chain |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JAK1 | up-regulates
phosphorylation
|
STAT1 |
0.79 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256247 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21576360 |
When IFN-γ binds to its receptor, the receptor-associated protein tyrosine kinases Janus kinase I (JAK1) and JAK2 are activated (37). This leads to the phosphorylation of STAT1, which then dimerizes, translocates to the nucleus, and activates its target promoters, including the pIV promoter of Ciita |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection, SARS-CoV CYTOKINE STORM |
| + |
Upadacitinib | down-regulates activity
binding
|
JAK1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272504 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33240390 |
Upadacitinib (ABT-494) is another selective inhibitor of JAK1 undergoing clinical trials to determine its benefit for several inflammatory diseases |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IFNAR | up-regulates activity
binding
|
JAK1 |
0.737 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260147 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15120645 |
Despite signaling through distinct receptor complexes, type I IFNs and IFN-lambda activate similar signaling events and biological activities, consistent with their common ability to mediate an antiviral state in cells (Fig. 6). In both cases, receptor engagement leads via the activation of the Jak kinases Jak1 and Tyk2 to the activation of the IFN-stimulated gene factor 3 (ISGF3) transcription complex, composed of latent transcriptional factors of the Signal Transducers and Activators of Transcription (STAT) family, Stat1 and Stat2, and of the interferon regulatory factor (IRF) IRF9 (ISGF3g or p48). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, EBV infection, Inflammosome Activation, SARS-CoV CYTOKINE STORM, SARS-CoV INFLAMMATORY RESPONSE |
| + |
IL4R | up-regulates activity
phosphorylation
|
JAK1 |
0.716 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249529 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 23124025 |
Although the receptor-associated tyrosine kinases Jak2 and Tyk2 are activated after the recruitment of IL-13 to its receptor (containing IL-4R and IL-13R1), IL-4 stimulates Jak1 activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Multiple sclerosis |
| + |
ruxolitinib | down-regulates
chemical inhibition
|
JAK1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-206667 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN6 | down-regulates
dephosphorylation
|
JAK1 |
0.643 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-119197 |
|
|
Homo sapiens |
Breast Cancer Cell, Leukemia Cell, Lymphoma Cell, JURKAT Cell, RAMOS Cell |
| pmid |
sentence |
| 14624462 |
We find, for the first time, that shp-1 down-regulates the level of tyk2 kinase in h9 cells and of jak1 kinase in htb26 cells, by accelerating their degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOCS1 | down-regulates
binding
|
JAK1 |
0.731 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-202042 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23663276 |
Socs1 and socs3 target jak1 and gp130, respectively, near the plasma membrane to prevent cytoplasmic stats from being activated, whereas pias1 principally targets activated stat1 in the cell nucleus and prevents it from binding to dna. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-85352 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11133764 |
Jab/socs1/ssi-1 is an il-2 induced inhibitor of il-2 signaling that functions by inhibiting jak kinase activity |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | IL6 Signaling |
| + |
IL31RA | up-regulates
binding
|
JAK1 |
0.494 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-161342 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 18926762 |
Il-31 can activate janus kinase (jak) 1 and jak2 signaling molecules after binding to its receptor complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JAK1 | up-regulates activity
phosphorylation
|
STAT6 |
0.765 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249531 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 23124025 |
IL-4-stimulated Stat6 activation is mediated by Jak1 whereas Tyk2 is required for Stat6 activation in IL-13-treated monocytes |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-62582 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9852261 |
Stat6 activation is mediated through jak1 and jak2 tyrosine kinases |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
AZD1480 | down-regulates
chemical inhibition
|
JAK1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-190164 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOCS3 | down-regulates activity
binding
|
JAK1 |
0.731 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253051 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23454976 |
SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL6 Signaling |
| + |
IFNGR1 | up-regulates
binding
|
JAK1 |
0.702 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-135952 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15864272 |
The only type ii ifn, ifn-g, binds a distinct cell-surface receptor, which is known as the type ii ifn receptor. This receptor is also composed of two subunits, ifngr1 and ifngr2, which are associated with jak1 and jak2, respectively. Activation of the jaks that are associated with the type i ifn receptor results in tyrosine phosphorylation of stat2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-150194 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17063185 |
Interferon- (ifn;type ii ifn) induces reorganization of the ifn-receptor subunits, ifngr1 and ifngr2, activating the janus kinases jak1 and jak2, which are constitutively associated with each subunit, respectively |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
JAK1 | up-regulates activity
phosphorylation
|
IFNGR2 |
0.66 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249491 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19041276 |
The activation of this signaling pathway involves the binding of IFN-g to two IFN-g receptor (IFN-gR) subunits, made up of respective IFNgR1:IFNgR2 pairs, which dimerize upon IFN-g binding to form the IFN-gR complex. Two JAKs, JAK1and JAK2,which bind to each IFN-gR subunits, respectively through their N-terminal domains, both become activated by tyrosine phosphorylation in a JAK2-dependent process. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL4R | up-regulates
binding
|
JAK1 |
0.716 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-100774 |
|
|
Homo sapiens |
T-lymphocyte, Macrophage, Monocyte |
| pmid |
sentence |
| 12704343 |
IL-4Rα, γc, and IL-13Rα1 all contain proline-rich box-1 regions that bind jak1, jak3, and tyk2, respectively. Il-4 uses the type ii receptor, and IL-13R1 Binds tyk2. Il-13 results in activation of jak1 and tyk2 in hematopoietic and nonhematopoietic cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Lung, Smooth Muscle |
| Pathways: | Multiple sclerosis |
| + |
ruxolitinib phosphate | down-regulates activity
chemical inhibition
|
JAK1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259170 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23061804 |
Ruxolitinib is a selective inhibitor of Janus kinases (JAK) 1 and 2, which are involved in the signalling pathway of various cytokines and growth factors essential to haematopoiesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JAK1 | up-regulates activity
phosphorylation
|
IRS1 |
0.707 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251343 |
|
|
Mus musculus |
32D Cell |
| pmid |
sentence |
| 9305869 |
Janus kinase-dependent activation of insulin receptor substrate 1 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
IFNLR1 | up-regulates
binding
|
JAK1 |
0.778 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-124480 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15120645 |
Each r1-type chain (il-10r1, il-20r1, il-22r1, ifn-_r1 and ifn-_r1) is associated with jak1 tyrosine kinase and mediates recruitment of a variety of signaling molecules after being phosphorylated on its intracellular domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JAK1 | up-regulates activity
phosphorylation
|
IFNGR1 |
0.702 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249488 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 19041276 |
The activation of this signaling pathway involves the binding of IFN-g to two IFN-g receptor (IFN-gR) subunits, made up of respective IFNgR1:IFNgR2 pairs, which dimerize upon IFN-g binding to form the IFN-gR complex. Two JAKs, JAK1and JAK2,which bind to each IFN-gR subunits, respectively through their N-terminal domains, both become activated by tyrosine phosphorylation in a JAK2-dependent process. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL4R | up-regulates
|
JAK1 |
0.716 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-34756 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7538655 |
We demonstrate that il4r triggering induced the tyrosine phosphorylation of jak3 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Multiple sclerosis |
| + |
IL7R | up-regulates
binding
|
JAK1 |
0.636 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178494 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 18445337 |
For instance, jak1 is associated with the ? Subunits of ?c Cytokines such as il-7r? And IL-4R. jak3 is associated with the ?c20,21. Cytokine binding mediates the trans-phosphorylation of receptor associated jak kinases, which in turn phosphorylate tyrosine residues on the receptors themselves. The receptor phosphotyrosines serve as docking sites for sh2 domain proteins including the stat family of transcription factors which are activated by jak-mediated phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JAK1 | up-regulates
|
JAK3 |
0.532 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-77551 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10825200 |
Syk activation required jak3, probably indirectly via activation of jak1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JAK1 | up-regulates
phosphorylation
|
JAK3 |
0.532 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152914 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 17259970 |
Il-7r signalling is initiated when il-7 crosslinks the extracellular domains of il-7ralpha and gammac, bringing together jak1 and jak3, which mutually phosphorylate each other, increasing their kinase activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JAK1 | form complex 
binding
|
JAK1/STAT1/STAT3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235608 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15284024 |
Stimulation of EGFR induces Tyr701 phosphorylation of STAT1 and initiates complex formation of STAT1 and STAT3 with JAK1 and JAK2. Thereafter, the STATs translocate to the nucleus within 15 min. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
IFNB1 | up-regulates
|
JAK1 |
0.538 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-80100 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10918594 |
Early events in type i ifn signaling are tyrosine phosphorylation of the type i ifn receptor subunits (ifnar1 and ifnar2), and the activation of the receptor-associated tyk-2 and jak-1 janus kinases |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection, SARS-CoV CYTOKINE STORM |
3.0
JAK1
