| Name | JAK1 |
| ID | P23458 |
| Role | substrate |
| Enzymatic Domains |
FERM 34-420 PROSITE-ProRule
SH2 439-544 PROSITE-ProRule
Protein kinase 1 583-855 PROSITE-ProRule
Protein kinase 2 875-1153 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRC | JAK1 | Tyr1035 | IETDKEYyTVKDDRD | dephosphorylation down-regulates activity | 11201744 | SIGNOR-248356 |
| PTPN2 | JAK1 | Tyr1035 | IETDKEYyTVKDDRD | dephosphorylation down-regulates activity | 11909529 | SIGNOR-248396 |
| PTPN2 | JAK1 | – | dephosphorylation down-regulates activity | 15780598 | SIGNOR-134620 | |
| IL4R | JAK1 | – | phosphorylation up-regulates activity | 23124025 | SIGNOR-249529 | |
| PTPN6 | JAK1 | – | dephosphorylation down-regulates | 14624462 | SIGNOR-119197 | |
| JAK3 | JAK1 | Tyr1035 | IETDKEYyTVKDDRD | phosphorylation up-regulates activity | 12559972 | SIGNOR-251364 |
| JAK3 | JAK1 | Tyr1034 | AIETDKEyYTVKDDR | phosphorylation up-regulates activity | 12559972 | SIGNOR-251363 |
| JAK3 | JAK1 | – | phosphorylation up-regulates | 17259970 | SIGNOR-152917 | |
| PTPN2 | JAK1 | Tyr1034 | AIETDKEyYTVKDDR | dephosphorylation down-regulates activity | 11909529 | SIGNOR-248395 |
| PTPRC | JAK1 | Tyr1034 | AIETDKEyYTVKDDR | dephosphorylation down-regulates activity | 11201744 | SIGNOR-248355 |
| PTPRC | JAK1 | – | dephosphorylation up-regulates | 11994288 | SIGNOR-87154 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRC | dephosphorylation down-regulates ⊣ | JAK1 PTyr1035 | dephosphorylation up-regulates → | JAK1 | 11201744 | SIGNOR-248356 |
| PTPN2 | dephosphorylation down-regulates ⊣ | JAK1 PTyr1035 | dephosphorylation up-regulates → | JAK1 | 11909529 | SIGNOR-248396 |
| JAK3 | phosphorylation up-regulates → | JAK1 PTyr1035 | phosphorylation up-regulates → | JAK1 | 12559972 | SIGNOR-251364 |
| JAK3 | phosphorylation up-regulates → | JAK1 PTyr1034 | phosphorylation up-regulates → | JAK1 | 12559972 | SIGNOR-251363 |
| PTPN2 | dephosphorylation down-regulates ⊣ | JAK1 PTyr1034 | dephosphorylation up-regulates → | JAK1 | 11909529 | SIGNOR-248395 |
| PTPRC | dephosphorylation down-regulates ⊣ | JAK1 PTyr1034 | dephosphorylation up-regulates → | JAK1 | 11201744 | SIGNOR-248355 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRC | dephosphorylation → down-regulates activity | JAK1 | SIGNOR-248356 |
| PTPN2 | dephosphorylation → down-regulates activity | JAK1 | SIGNOR-248396 |
| PTPN2 | dephosphorylation → down-regulates activity | JAK1 | SIGNOR-134620 |
| IL4R | phosphorylation → up-regulates activity | JAK1 | SIGNOR-249529 |
| PTPN6 | dephosphorylation down-regulates | JAK1 | SIGNOR-119197 |
| JAK3 | phosphorylation → up-regulates activity | JAK1 | SIGNOR-251364 |
| JAK3 | phosphorylation → up-regulates activity | JAK1 | SIGNOR-251363 |
| JAK3 | phosphorylation → up-regulates | JAK1 | SIGNOR-152917 |
| PTPN2 | dephosphorylation → down-regulates activity | JAK1 | SIGNOR-248395 |
| PTPRC | dephosphorylation → down-regulates activity | JAK1 | SIGNOR-248355 |
| PTPRC | dephosphorylation → up-regulates | JAK1 | SIGNOR-87154 |