Entity Details

Name PTPN2_Tyr1035
ID P23458
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PTPN2JAK1Tyr1035IETDKEYyTVKDDRDdephosphorylation
down-regulates activity		11909529SIGNOR-248396
PTPRCJAK1Tyr1035IETDKEYyTVKDDRDdephosphorylation
down-regulates activity		11201744SIGNOR-248356
JAK3JAK1Tyr1035IETDKEYyTVKDDRDphosphorylation
up-regulates activity		12559972SIGNOR-251364
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PTPN2dephosphorylation
down-regulates
⊣
JAK1
PTyr1035		dephosphorylation
up-regulates
→		JAK111909529SIGNOR-248396
PTPRCdephosphorylation
down-regulates
⊣
JAK1
PTyr1035		dephosphorylation
up-regulates
→		JAK111201744SIGNOR-248356
JAK3phosphorylation
up-regulates
→
JAK1
PTyr1035		phosphorylation
up-regulates
→		JAK112559972SIGNOR-251364
Regulator Mechanism/Effect Target SIGNOR-ID
PTPN2dephosphorylation
→
down-regulates activity 		JAK1SIGNOR-248396
PTPRCdephosphorylation
→
down-regulates activity 		JAK1SIGNOR-248356
JAK3phosphorylation
→
up-regulates activity 		JAK1SIGNOR-251364