| Name | PTPRB |
| ID | P23467 |
| Role | phosphatase |
| Enzymatic Domains |
Fibronectin type-III 1 23-111 PROSITE-ProRule
Fibronectin type-III 2 112-207 PROSITE-ProRule
Fibronectin type-III 3 203-288 PROSITE-ProRule
Fibronectin type-III 4 291-378 PROSITE-ProRule
Fibronectin type-III 5 379-471 PROSITE-ProRule
Fibronectin type-III 6 467-552 PROSITE-ProRule
Fibronectin type-III 7 556-641 PROSITE-ProRule
Fibronectin type-III 8 642-729 PROSITE-ProRule
Fibronectin type-III 9 730-829 PROSITE-ProRule
Fibronectin type-III 10 819-906 PROSITE-ProRule
Fibronectin type-III 11 909-1001 PROSITE-ProRule
Fibronectin type-III 12 995-1083 PROSITE-ProRule
Fibronectin type-III 13 1087-1175 PROSITE-ProRule
Fibronectin type-III 14 1173-1260 PROSITE-ProRule
Fibronectin type-III 15 1260-1356 PROSITE-ProRule
Fibronectin type-III 16 1357-1448 PROSITE-ProRule
Fibronectin type-III 17 1458-1554 PROSITE-ProRule
Tyrosine-protein phosphatase 1703-1963 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRB | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates | 10734133 | SIGNOR-75989 |
| PTPRB | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates | 10734133 | SIGNOR-75993 |
| PTPRB | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation down-regulates | 10734133 | SIGNOR-75997 |
| PTPRB | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates | 10734133 | SIGNOR-76001 |
| PTPRB | MET | Tyr1356 | YVHVNATyVNVKCVA | dephosphorylation down-regulates | 16101282 | SIGNOR-139560 |
| PTPRB | MET | Tyr1356 | YVHVNATyVNVKCVA | dephosphorylation down-regulates | 21454675 | SIGNOR-173004 |
| PTPRB | MET | Tyr1356 | YVHVNATyVNVKCVA | dephosphorylation down-regulates activity | 21454675 | SIGNOR-248440 |
| PTPRB | GHR | – | dephosphorylation down-regulates | 12907755 | SIGNOR-104580 | |
| PTPRB | SRC | – | dephosphorylation down-regulates activity | 27314562 | SIGNOR-277132 | |
| PTPRB | MAPK3 | – | dephosphorylation up-regulates | 12840032 | SIGNOR-103165 | |
| PTPRB | MAPK1 | – | dephosphorylation down-regulates | 21454675 | SIGNOR-173000 | |
| PTPRB | NOS3 | Tyr81 | WEVGSITyDTLSAQA | dephosphorylation down-regulates activity | 32653904 | SIGNOR-277041 |
| PTPRB | NOS3 | Tyr81 | WEVGSITyDTLSAQA | dephosphorylation down-regulates activity | 32653904 | SIGNOR-277521 |
| PTPRB | CDH5 | – | dephosphorylation up-regulates activity | 19015309 | SIGNOR-277131 | |
| PTPRB | KDR | Tyr1175 | AQQDGKDyIVLPISE | dephosphorylation down-regulates activity | 19136612 | SIGNOR-248441 |
| PTPRB | TEK | – | dephosphorylation down-regulates activity | 34417472 | SIGNOR-277059 | |
| PTPRB | ALK | – | dephosphorylation down-regulates | 17681947 | SIGNOR-157175 | |
| PTPRB | ERK1/2 | – | dephosphorylation up-regulates | 12840032 | SIGNOR-269931 | |
| PTPRB | Gbeta | – | dephosphorylation up-regulates | 12840032 | SIGNOR-269911 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRB | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75989 |
| PTPRB | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75993 |
| PTPRB | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75997 |
| PTPRB | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76001 |
| PTPRB | dephosphorylation down-regulates ⊣ | MET PTyr1356 | dephosphorylation up-regulates → | MET | 16101282 | SIGNOR-139560 |
| PTPRB | dephosphorylation down-regulates ⊣ | MET PTyr1356 | dephosphorylation up-regulates → | MET | 21454675 | SIGNOR-173004 |
| PTPRB | dephosphorylation down-regulates ⊣ | MET PTyr1356 | dephosphorylation up-regulates → | MET | 21454675 | SIGNOR-248440 |
| PTPRB | dephosphorylation down-regulates ⊣ | NOS3 PTyr81 | dephosphorylation up-regulates → | NOS3 | 32653904 | SIGNOR-277041 |
| PTPRB | dephosphorylation down-regulates ⊣ | NOS3 PTyr81 | dephosphorylation up-regulates → | NOS3 | 32653904 | SIGNOR-277521 |
| PTPRB | dephosphorylation down-regulates ⊣ | KDR PTyr1175 | dephosphorylation up-regulates → | KDR | 19136612 | SIGNOR-248441 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRB | dephosphorylation down-regulates | INSR | SIGNOR-75989 |
| PTPRB | dephosphorylation down-regulates | INSR | SIGNOR-75993 |
| PTPRB | dephosphorylation down-regulates | INSR | SIGNOR-75997 |
| PTPRB | dephosphorylation down-regulates | INSR | SIGNOR-76001 |
| PTPRB | dephosphorylation down-regulates | MET | SIGNOR-139560 |
| PTPRB | dephosphorylation down-regulates | MET | SIGNOR-173004 |
| PTPRB | dephosphorylation → down-regulates activity | MET | SIGNOR-248440 |
| PTPRB | dephosphorylation down-regulates | GHR | SIGNOR-104580 |
| PTPRB | dephosphorylation → down-regulates activity | SRC | SIGNOR-277132 |
| PTPRB | dephosphorylation → up-regulates | MAPK3 | SIGNOR-103165 |
| PTPRB | dephosphorylation down-regulates | MAPK1 | SIGNOR-173000 |
| PTPRB | dephosphorylation → down-regulates activity | NOS3 | SIGNOR-277041 |
| PTPRB | dephosphorylation → down-regulates activity | NOS3 | SIGNOR-277521 |
| PTPRB | dephosphorylation → up-regulates activity | CDH5 | SIGNOR-277131 |
| PTPRB | dephosphorylation → down-regulates activity | KDR | SIGNOR-248441 |
| PTPRB | dephosphorylation → down-regulates activity | TEK | SIGNOR-277059 |
| PTPRB | dephosphorylation down-regulates | ALK | SIGNOR-157175 |
| PTPRB | dephosphorylation → up-regulates | ERK1/2 | SIGNOR-269931 |
| PTPRB | dephosphorylation → up-regulates | Gbeta | SIGNOR-269911 |