Summary

Name PTPRB
Full Name Receptor-type tyrosine-protein phosphatase beta
Synonyms Protein-tyrosine phosphatase beta, R-PTP-beta, Vascular endothelial protein tyrosine phosphatase, VE-PTP | PTPB
Primary ID P23467
Links - -
Type protein
Relations 14
Function Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png dephosphorylation KDR 0.472
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation INSR 0.349
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MET 0.371
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation MET 0.371
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation Gbeta 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation GHR 0.298
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation MAPK3 0.444
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation ERK1/2 0.444
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation ALK 0.342
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK1 0.39
Publications: 1 Organism: Homo Sapiens