Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PTPRE	INSR	Tyr1185	FGMTRDIyETDYYRK	dephosphorylation down-regulates activity	15738637	SIGNOR-248444
PTPRE	INSR	Tyr1189	RDIYETDyYRKGGKG	dephosphorylation down-regulates activity	15738637	SIGNOR-248445
PTPRE	INSR	Tyr1190	DIYETDYyRKGGKGL	dephosphorylation down-regulates activity	15738637	SIGNOR-248446
PTPRE	INSR	Tyr999	YASSNPEyLSASDVF	dephosphorylation down-regulates activity	15738637	SIGNOR-248443
PTPRE	SRC	Tyr530	FTSTEPQyQPGENL	dephosphorylation up-regulates activity	15522235	SIGNOR-238074
PTPRE	MAPK1	Thr185	HDHTGFLtEYVATRW	dephosphorylation down-regulates activity	12754301	SIGNOR-248449
PTPRE	MAPK1	Tyr187	HTGFLTEyVATRWYR	dephosphorylation down-regulates activity	12754301	SIGNOR-248448
PTPRE	KCNB1	Tyr128	YWGIDEIyLESCCQA	dephosphorylation down-regulates activity	10921884	SIGNOR-248450

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PTPRE	dephosphorylation down-regulates ⊣	INSR PTyr1185	dephosphorylation up-regulates →	INSR	15738637	SIGNOR-248444
PTPRE	dephosphorylation down-regulates ⊣	INSR PTyr1189	dephosphorylation up-regulates →	INSR	15738637	SIGNOR-248445
PTPRE	dephosphorylation down-regulates ⊣	INSR PTyr1190	dephosphorylation up-regulates →	INSR	15738637	SIGNOR-248446
PTPRE	dephosphorylation down-regulates ⊣	INSR PTyr999	dephosphorylation up-regulates →	INSR	15738637	SIGNOR-248443
PTPRE	dephosphorylation down-regulates ⊣	SRC PTyr530	dephosphorylation down-regulates ⊣	SRC	15522235	SIGNOR-238074
PTPRE	dephosphorylation down-regulates ⊣	MAPK1 PThr185	dephosphorylation up-regulates →	MAPK1	12754301	SIGNOR-248449
PTPRE	dephosphorylation down-regulates ⊣	MAPK1 PTyr187	dephosphorylation up-regulates →	MAPK1	12754301	SIGNOR-248448
PTPRE	dephosphorylation down-regulates ⊣	KCNB1 PTyr128	dephosphorylation up-regulates →	KCNB1	10921884	SIGNOR-248450

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PTPRE	dephosphorylation → down-regulates activity	INSR	SIGNOR-248444
PTPRE	dephosphorylation → down-regulates activity	INSR	SIGNOR-248445
PTPRE	dephosphorylation → down-regulates activity	INSR	SIGNOR-248446
PTPRE	dephosphorylation → down-regulates activity	INSR	SIGNOR-248443
PTPRE	dephosphorylation → up-regulates activity	SRC	SIGNOR-238074
PTPRE	dephosphorylation → down-regulates activity	MAPK1	SIGNOR-248449
PTPRE	dephosphorylation → down-regulates activity	MAPK1	SIGNOR-248448
PTPRE	dephosphorylation → down-regulates activity	KCNB1	SIGNOR-248450