| + |
PTPRE | down-regulates activity 
dephosphorylation
|
MAPK1 |
0.398 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248449 |
Thr185 |
HDHTGFLtEYVATRW |
Homo sapiens |
|
| pmid |
sentence |
| 12754301 |
The effect of PTP epsilon on ERKs is at least in part indirect because phosphorylation of the threonine residue in the ERK activation loop is reduced in the presence of PTP epsilon. Nonetheless, PTP epsilon is present in a molecular complex with ERK, providing PTP epsilon with opportunity to act on ERK proteins also directly. We conclude that PTP epsilon is a physiological inhibitor of ERK signaling|These enzymes are joined by the large family of dual-specificity phosphatases, which are structurally similar to tyrosine phosphatases but which can dephosphorylate both residues of the activation loop |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248448 |
Tyr187 |
HTGFLTEyVATRWYR |
Homo sapiens |
|
| pmid |
sentence |
| 12754301 |
The effect of PTP epsilon on ERKs is at least in part indirect because phosphorylation of the threonine residue in the ERK activation loop is reduced in the presence of PTP epsilon. Nonetheless, PTP epsilon is present in a molecular complex with ERK, providing PTP epsilon with opportunity to act on ERK proteins also directly. We conclude that PTP epsilon is a physiological inhibitor of ERK signaling|These enzymes are joined by the large family of dual-specificity phosphatases, which are structurally similar to tyrosine phosphatases but which can dephosphorylate both residues of the activation loop |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PTPRE | down-regulates activity
dephosphorylation
|
INSR |
0.29 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248444 |
Tyr1185 |
FGMTRDIyETDYYRK |
Rattus norvegicus |
Hepatocyte |
| pmid |
sentence |
| 15738637 |
In this study, we showed that receptor-type PTPepsilon (PTP epsilonM) dephosphorylated IR in rat primary hepatocytes and tyrosines 972, 1158, 1162 and 1163| These results suggest that PTPepsilonM is a negative regulator of IR signaling and involved in insulin-induced glucose metabolism mainly through direct dephosphorylation and inactivation of IR in hepatocytes and liver. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248445 |
Tyr1189 |
RDIYETDyYRKGGKG |
Rattus norvegicus |
Hepatocyte |
| pmid |
sentence |
| 15738637 |
In this study, we showed that receptor-type PTPepsilon (PTP epsilonM) dephosphorylated IR in rat primary hepatocytes and tyrosines 972, 1158, 1162 and 1163| These results suggest that PTPepsilonM is a negative regulator of IR signaling and involved in insulin-induced glucose metabolism mainly through direct dephosphorylation and inactivation of IR in hepatocytes and liver. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248446 |
Tyr1190 |
DIYETDYyRKGGKGL |
Rattus norvegicus |
Hepatocyte |
| pmid |
sentence |
| 15738637 |
In this study, we showed that receptor-type PTPepsilon (PTP epsilonM) dephosphorylated IR in rat primary hepatocytes and tyrosines 972, 1158, 1162 and 1163| These results suggest that PTPepsilonM is a negative regulator of IR signaling and involved in insulin-induced glucose metabolism mainly through direct dephosphorylation and inactivation of IR in hepatocytes and liver. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248443 |
Tyr999 |
YASSNPEyLSASDVF |
Rattus norvegicus |
|
| pmid |
sentence |
| 15738637 |
In this study, we showed that receptor-type PTPepsilon (PTP epsilonM) dephosphorylated IR in rat primary hepatocytes and tyrosines 972, 1158, 1162 and 1163| These results suggest that PTPepsilonM is a negative regulator of IR signaling and involved in insulin-induced glucose metabolism mainly through direct dephosphorylation and inactivation of IR in hepatocytes and liver. |
|
| Publications: |
4 |
Organism: |
Rattus Norvegicus |
| + |
PTPRE | down-regulates activity
dephosphorylation
|
KCNB1 |
0.362 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248450 |
Tyr128 |
YWGIDEIyLESCCQA |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 10921884 |
Hypomyelination and increased activity of voltage-gated K(+) channels in mice lacking protein tyrosine phosphatase epsilon |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPRE | up-regulates activity 
dephosphorylation
|
SRC |
0.411 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238074 |
Tyr530 |
FTSTEPQyQPGENL |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 15522235 |
PTPepsilonM activated c-Src kinase probably by directly dephosphorylating phospho-Tyr527, a negative regulatory site of c-Src. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
3.0
PTPRE
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