| Name | CCND1 |
| ID | P24385 |
| Role | substrate |
| Enzymatic Domains |
Cyclin N-terminal 28-152 |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | CCND1 | Thr286 | EEVDLACtPTDVRDV | phosphorylation down-regulates | 9832503 | SIGNOR-62265 |
| DYRK1A | CCND1 | Thr286 | EEVDLACtPTDVRDV | phosphorylation down-regulates | 24119401 | SIGNOR-202838 |
| DYRK1B | CCND1 | Thr288 | VDLACTPtDVRDVDI | phosphorylation down-regulates | 17046823 | SIGNOR-150126 |
| PRKACA | CCND1 | Ser90 | NYLDRFLsLEPVKKS | phosphorylation unknown | 8058338 | SIGNOR-250347 |
| MAPK14 | CCND1 | – | phosphorylation up-regulates | 20626350 | SIGNOR-166594 | |
| GSK3B | CCND1 | Thr286 | EEVDLACtPTDVRDV | phosphorylation down-regulates quantity by destabilization | 23552696 | SIGNOR-245437 |
| DYRK1B | CCND1 | Thr288 | VDLACTPtDVRDVDI | phosphorylation down-regulates | 15546868 | SIGNOR-235801 |
| GSK3B | CCND1 | Thr286 | EEVDLACtPTDVRDV | phosphorylation down-regulates | 16504004 | SIGNOR-144818 |
| PRKACA | CCND1 | Ser234 | YRLTRFLsRVIKCDP | phosphorylation unknown | 8058338 | SIGNOR-250346 |
| CHUK | CCND1 | Thr286 | EEVDLACtPTDVRDV | phosphorylation down-regulates | 16103118 | SIGNOR-139570 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | phosphorylation up-regulates → | CCND1 PThr286 | phosphorylation down-regulates ⊣ | CCND1 | 9832503 | SIGNOR-62265 |
| DYRK1A | phosphorylation up-regulates → | CCND1 PThr286 | phosphorylation down-regulates ⊣ | CCND1 | 24119401 | SIGNOR-202838 |
| DYRK1B | phosphorylation up-regulates → | CCND1 PThr288 | phosphorylation down-regulates ⊣ | CCND1 | 17046823 | SIGNOR-150126 |
| PRKACA | phosphorylation up-regulates → | CCND1 PSer90 | phosphorylation down-regulates ⊣ | CCND1 | 8058338 | SIGNOR-250347 |
| GSK3B | phosphorylation up-regulates → | CCND1 PThr286 | phosphorylation down-regulates ⊣ | CCND1 | 23552696 | SIGNOR-245437 |
| DYRK1B | phosphorylation up-regulates → | CCND1 PThr288 | phosphorylation down-regulates ⊣ | CCND1 | 15546868 | SIGNOR-235801 |
| GSK3B | phosphorylation up-regulates → | CCND1 PThr286 | phosphorylation down-regulates ⊣ | CCND1 | 16504004 | SIGNOR-144818 |
| PRKACA | phosphorylation up-regulates → | CCND1 PSer234 | phosphorylation down-regulates ⊣ | CCND1 | 8058338 | SIGNOR-250346 |
| CHUK | phosphorylation up-regulates → | CCND1 PThr286 | phosphorylation down-regulates ⊣ | CCND1 | 16103118 | SIGNOR-139570 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B | phosphorylation down-regulates | CCND1 | SIGNOR-62265 |
| DYRK1A | phosphorylation down-regulates | CCND1 | SIGNOR-202838 |
| DYRK1B | phosphorylation down-regulates | CCND1 | SIGNOR-150126 |
| PRKACA | phosphorylation → unknown | CCND1 | SIGNOR-250347 |
| MAPK14 | phosphorylation → up-regulates | CCND1 | SIGNOR-166594 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | CCND1 | SIGNOR-245437 |
| DYRK1B | phosphorylation down-regulates | CCND1 | SIGNOR-235801 |
| GSK3B | phosphorylation down-regulates | CCND1 | SIGNOR-144818 |
| PRKACA | phosphorylation → unknown | CCND1 | SIGNOR-250346 |
| CHUK | phosphorylation down-regulates | CCND1 | SIGNOR-139570 |