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Summary
| Name |  CCND1View Modifications |
| Full Name | G1/S-specific cyclin-D1 |
| Synonyms | B-cell lymphoma 1 protein, BCL-1, BCL-1 oncogene, PRAD1 oncogene | BCL1, PRAD1 |
| Primary ID | P24385 |
| Links |  -  -  |
| Type | protein |
| Relations | 70 |
| Pathways | Acute Myeloid Leukemia, DNMT3A in AML, AML_TRIPLETS, Triple mutant AML, Satellite: IL1 |
| Inhibitors | 4-(2,6-dichlorobenzamido)-N-(piperidin-4-yl)-pyrazole-3-carboxamide; R547; palbociclib |
| Function | Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ |
|---|---|
| + | PRKACA |