| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | CCND1 | Thr286 | EEVDLACtPTDVRDV | phosphorylation down-regulates | 9832503 | SIGNOR-62265 |
| DYRK1A | CCND1 | Thr286 | EEVDLACtPTDVRDV | phosphorylation down-regulates | 24119401 | SIGNOR-202838 |
| GSK3B | CCND1 | Thr286 | EEVDLACtPTDVRDV | phosphorylation down-regulates quantity by destabilization | 23552696 | SIGNOR-245437 |
| GSK3B | CCND1 | Thr286 | EEVDLACtPTDVRDV | phosphorylation down-regulates | 16504004 | SIGNOR-144818 |
| CHUK | CCND1 | Thr286 | EEVDLACtPTDVRDV | phosphorylation down-regulates | 16103118 | SIGNOR-139570 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | phosphorylation up-regulates → | CCND1 PThr286 | phosphorylation down-regulates ⊣ | CCND1 | 9832503 | SIGNOR-62265 |
| DYRK1A | phosphorylation up-regulates → | CCND1 PThr286 | phosphorylation down-regulates ⊣ | CCND1 | 24119401 | SIGNOR-202838 |
| GSK3B | phosphorylation up-regulates → | CCND1 PThr286 | phosphorylation down-regulates ⊣ | CCND1 | 23552696 | SIGNOR-245437 |
| GSK3B | phosphorylation up-regulates → | CCND1 PThr286 | phosphorylation down-regulates ⊣ | CCND1 | 16504004 | SIGNOR-144818 |
| CHUK | phosphorylation up-regulates → | CCND1 PThr286 | phosphorylation down-regulates ⊣ | CCND1 | 16103118 | SIGNOR-139570 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B | phosphorylation down-regulates | CCND1 | SIGNOR-62265 |
| DYRK1A | phosphorylation down-regulates | CCND1 | SIGNOR-202838 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | CCND1 | SIGNOR-245437 |
| GSK3B | phosphorylation down-regulates | CCND1 | SIGNOR-144818 |
| CHUK | phosphorylation down-regulates | CCND1 | SIGNOR-139570 |
