Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
CDK2	CCNE1	Ser399	GLLTPPQsGKKQSSG	phosphorylation down-regulates	14536078	SIGNOR-118555
GSK3B	CCNE1	Thr395 View in OncoXplorer	PLPSGLLtPPQSGKK	phosphorylation down-regulates	14536078	SIGNOR-118559
CDK2	CCNE1	Thr395 View in OncoXplorer	PLPSGLLtPPQSGKK	phosphorylation down-regulates	19561641	SIGNOR-186418
CDK2	CCNE1	Ser387 View in OncoXplorer	LSEQNRAsPLPSGLL	phosphorylation down-regulates	19561641	SIGNOR-186414
GSK3B	CCNE1	Thr77	DPCSLIPtPDKEDDD	phosphorylation down-regulates	14536078	SIGNOR-118563

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
CDK2	phosphorylation up-regulates →	CCNE1 PSer399	phosphorylation down-regulates ⊣	CCNE1	14536078	SIGNOR-118555
GSK3B	phosphorylation up-regulates →	CCNE1 PThr395	phosphorylation down-regulates ⊣	CCNE1	14536078	SIGNOR-118559
CDK2	phosphorylation up-regulates →	CCNE1 PThr395	phosphorylation down-regulates ⊣	CCNE1	19561641	SIGNOR-186418
CDK2	phosphorylation up-regulates →	CCNE1 PSer387	phosphorylation down-regulates ⊣	CCNE1	19561641	SIGNOR-186414
GSK3B	phosphorylation up-regulates →	CCNE1 PThr77	phosphorylation down-regulates ⊣	CCNE1	14536078	SIGNOR-118563

Regulator	Mechanism/Effect	Target	SIGNOR-ID
CDK2	phosphorylation down-regulates	CCNE1	SIGNOR-118555
GSK3B	phosphorylation down-regulates	CCNE1	SIGNOR-118559
CDK2	phosphorylation down-regulates	CCNE1	SIGNOR-186418
CDK2	phosphorylation down-regulates	CCNE1	SIGNOR-186414
GSK3B	phosphorylation down-regulates	CCNE1	SIGNOR-118563