| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | CCNE1 | Thr395 | PLPSGLLtPPQSGKK | phosphorylation down-regulates | 14536078 | SIGNOR-118559 |
| CDK2 | CCNE1 | Thr395 | PLPSGLLtPPQSGKK | phosphorylation down-regulates | 19561641 | SIGNOR-186418 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | phosphorylation up-regulates → | CCNE1 PThr395 | phosphorylation down-regulates ⊣ | CCNE1 | 14536078 | SIGNOR-118559 |
| CDK2 | phosphorylation up-regulates → | CCNE1 PThr395 | phosphorylation down-regulates ⊣ | CCNE1 | 19561641 | SIGNOR-186418 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B | phosphorylation![]() down-regulates | CCNE1 | SIGNOR-118559 |
| CDK2 | phosphorylation![]() down-regulates | CCNE1 | SIGNOR-186418 |