Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
GSK3B	APC	–		phosphorylation up-regulates	10698523	SIGNOR-75366
CDC14B	APC	–		dephosphorylation up-regulates	18662541	SIGNOR-179636
PRKACA	APC	Ser2054	MPKKKKPsRLKGDNE	phosphorylation down-regulates activity	11050185	SIGNOR-250335
CSNK1E	APC	Ser1392 View in OncoXplorer	SRCTSVSsLDSFESR	phosphorylation up-regulates activity	11487578	SIGNOR-109664
BUB1B	APC	–		phosphorylation up-regulates activity	17709426	SIGNOR-279393
CSNK1E	APC	Ser1279	SRCSSLSsLSSAEDE	phosphorylation up-regulates activity	11487578	SIGNOR-109660
KRT1	APC	–		phosphorylation up-regulates activity	18359618	SIGNOR-251879
PRKCD	APC	–		phosphorylation down-regulates activity	23520519	SIGNOR-279650

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PRKACA	phosphorylation up-regulates →	APC PSer2054	phosphorylation down-regulates ⊣	APC	11050185	SIGNOR-250335
CSNK1E	phosphorylation up-regulates →	APC PSer1392	phosphorylation up-regulates →	APC	11487578	SIGNOR-109664
CSNK1E	phosphorylation up-regulates →	APC PSer1279	phosphorylation up-regulates →	APC	11487578	SIGNOR-109660

Regulator	Mechanism/Effect	Target	SIGNOR-ID
GSK3B	phosphorylation → up-regulates	APC	SIGNOR-75366
CDC14B	dephosphorylation → up-regulates	APC	SIGNOR-179636
PRKACA	phosphorylation → down-regulates activity	APC	SIGNOR-250335
CSNK1E	phosphorylation → up-regulates activity	APC	SIGNOR-109664
BUB1B	phosphorylation → up-regulates activity	APC	SIGNOR-279393
CSNK1E	phosphorylation → up-regulates activity	APC	SIGNOR-109660
KRT1	phosphorylation → up-regulates activity	APC	SIGNOR-251879
PRKCD	phosphorylation → down-regulates activity	APC	SIGNOR-279650