Summary

Name APC
Full Name Adenomatous polyposis coli protein
Synonyms Protein APC, Deleted in polyposis 2.5 | DP2.5
Primary ID P25054
Links - -
Type protein
Relations 13
Function Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation APC 0.22
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation APC 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation APC 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding APC 0.22
Publications: 1 Organism: Homo Sapiens
Tissue: Brain, Kidney, Lung
+ down-regulates quantity img/direct_inhibition.png binding CTNNB1 0.37
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation APC 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding APC 0.36
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation ODC1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding APC 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization APC 0.38
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding GSK3B/Axin/APC 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation APC 0.36
Publications: 1 Organism: Homo Sapiens