| Name | MCM3 |
| ID | P25205 |
| Role | substrate |
| Enzymatic Domains |
MCM C-terminal AAA(+) ATPase 276-659 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinE/CDK2 | MCM3 | Thr722 | EEMPQVHtPKTADSQ | phosphorylation up-regulates | 21965652 | SIGNOR-216694 |
| DAPK1 | MCM3 | Ser160 | KTIERRYsDLTTLVA | phosphorylation unknown | 18283219 | SIGNOR-160958 |
| ATM | MCM3 | Ser535 | ATDDPNFsQEDQQDT | phosphorylation unknown | 15210935 | SIGNOR-126308 |
| CDK2 | MCM3 | Thr722 | EEMPQVHtPKTADSQ | phosphorylation up-regulates | 21965652 | SIGNOR-176656 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinE/CDK2 | phosphorylation up-regulates → | MCM3 PThr722 | phosphorylation up-regulates → | MCM3 | 21965652 | SIGNOR-216694 |
| DAPK1 | phosphorylation up-regulates → | MCM3 PSer160 | phosphorylation down-regulates ⊣ | MCM3 | 18283219 | SIGNOR-160958 |
| ATM | phosphorylation up-regulates → | MCM3 PSer535 | phosphorylation down-regulates ⊣ | MCM3 | 15210935 | SIGNOR-126308 |
| CDK2 | phosphorylation up-regulates → | MCM3 PThr722 | phosphorylation up-regulates → | MCM3 | 21965652 | SIGNOR-176656 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinE/CDK2 | phosphorylation → up-regulates | MCM3 | SIGNOR-216694 |
| DAPK1 | phosphorylation → unknown | MCM3 | SIGNOR-160958 |
| ATM | phosphorylation → unknown | MCM3 | SIGNOR-126308 |
| CDK2 | phosphorylation → up-regulates | MCM3 | SIGNOR-176656 |