| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | NFKBIA | Thr291 | EDEESYDtESEFTEF | phosphorylation down-regulates | 8622692 | SIGNOR-40514 |
| PTPN1 | NFKBIA | Tyr42 | DSMKDEEyEQMVKEL | dephosphorylation down-regulates | 8940099 | SIGNOR-45004 |
| CSNK2A1 | NFKBIA | Ser288 | PESEDEEsYDTESEF | phosphorylation down-regulates | 8622692 | SIGNOR-40506 |
| IKBKG | NFKBIA | Ser32 | LLDDRHDsGLDSMKD | phosphorylation down-regulates activity | 18412279 | SIGNOR-280462 |
| CSNK2A1 | NFKBIA | Ser283 | NLQMLPEsEDEESYD | phosphorylation down-regulates | 8622692 | SIGNOR-40502 |
| CHUK | NFKBIA | Ser36 | RHDSGLDsMKDEEYE | phosphorylation down-regulates quantity by destabilization | 9346241 | SIGNOR-52879 |
| RPS6KA2 | NFKBIA | Ser32 | LLDDRHDsGLDSMKD | phosphorylation down-regulates | 20385620 | SIGNOR-164790 |
| IKK-complex | NFKBIA | Ser36 | RHDSGLDsMKDEEYE | phosphorylation down-regulates quantity by destabilization | 9346241 | SIGNOR-209773 |
| CSNK2A1 | NFKBIA | Ser36 | RHDSGLDsMKDEEYE | phosphorylation down-regulates quantity by destabilization | 10398585 | SIGNOR-249333 |
| RPS6KA3 | NFKBIA | Ser32 | LLDDRHDsGLDSMKD | phosphorylation down-regulates quantity by destabilization | 20385620 | SIGNOR-279108 |
| AURKC | NFKBIA | Ser32 | LLDDRHDsGLDSMKD | phosphorylation up-regulates activity | 29050234 | SIGNOR-278470 |
| IKBKE | NFKBIA | – | phosphorylation down-regulates quantity by destabilization | 20717897 | SIGNOR-167524 | |
| CHUK | NFKBIA | Ser32 | LLDDRHDsGLDSMKD | phosphorylation down-regulates quantity by destabilization | 9346241 | SIGNOR-52875 |
| SRC | NFKBIA | Tyr42 | DSMKDEEyEQMVKEL | phosphorylation down-regulates quantity by destabilization | 9792645 | SIGNOR-60879 |
| IKBKB | NFKBIA | – | phosphorylation down-regulates activity | 21232017 | SIGNOR-235400 | |
| CSNK2A1 | NFKBIA | Ser32 | LLDDRHDsGLDSMKD | phosphorylation down-regulates quantity by destabilization | 10398585 | SIGNOR-249332 |
| CSNK2A1 | NFKBIA | Ser293 | EESYDTEsEFTEFTE | phosphorylation down-regulates | 8622692 | SIGNOR-40510 |
| EIF2AK2 | NFKBIA | Ser32 | LLDDRHDsGLDSMKD | phosphorylation down-regulates quantity by destabilization | 10723127 | SIGNOR-249335 |
| IKK-complex | NFKBIA | – | phosphorylation down-regulates | 21232017 | SIGNOR-216396 | |
| PTPN13 | NFKBIA | Tyr42 | DSMKDEEyEQMVKEL | dephosphorylation up-regulates quantity by stabilization | 11106428 | SIGNOR-248712 |
| AURKA | NFKBIA | Ser32 | LLDDRHDsGLDSMKD | phosphorylation down-regulates activity | 23993973 | SIGNOR-278912 |
| IKBKE | NFKBIA | Ser36 | RHDSGLDsMKDEEYE | phosphorylation down-regulates quantity by destabilization | 11815618 | SIGNOR-249367 |
| IKBKB | NFKBIA | Ser32 | LLDDRHDsGLDSMKD | phosphorylation down-regulates quantity by destabilization | 11815618 | SIGNOR-249365 |
| TBK1 | NFKBIA | Ser36 | RHDSGLDsMKDEEYE | phosphorylation down-regulates quantity by destabilization | 11815618 | SIGNOR-246643 |
| LCK | NFKBIA | Tyr42 | DSMKDEEyEQMVKEL | phosphorylation down-regulates quantity by destabilization | 14534291 | SIGNOR-249374 |
| IKK-complex | NFKBIA | Ser36 | RHDSGLDsMKDEEYE | phosphorylation down-regulates | 9346241 | SIGNOR-216389 |
| IKBKB | NFKBIA | Ser36 | RHDSGLDsMKDEEYE | phosphorylation down-regulates quantity by destabilization | 11815618 | SIGNOR-249366 |
| RPS6KA1 | NFKBIA | Ser32 | LLDDRHDsGLDSMKD | phosphorylation up-regulates activity | 10398585 | SIGNOR-279311 |
| IKK-complex | NFKBIA | Ser32 | LLDDRHDsGLDSMKD | phosphorylation down-regulates | 9346241 | SIGNOR-216385 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | phosphorylation up-regulates → | NFKBIA PThr291 | phosphorylation down-regulates ⊣ | NFKBIA | 8622692 | SIGNOR-40514 |
| PTPN1 | dephosphorylation down-regulates ⊣ | NFKBIA PTyr42 | dephosphorylation up-regulates → | NFKBIA | 8940099 | SIGNOR-45004 |
| CSNK2A1 | phosphorylation up-regulates → | NFKBIA PSer288 | phosphorylation down-regulates ⊣ | NFKBIA | 8622692 | SIGNOR-40506 |
| IKBKG | phosphorylation up-regulates → | NFKBIA PSer32 | phosphorylation down-regulates ⊣ | NFKBIA | 18412279 | SIGNOR-280462 |
| CSNK2A1 | phosphorylation up-regulates → | NFKBIA PSer283 | phosphorylation down-regulates ⊣ | NFKBIA | 8622692 | SIGNOR-40502 |
| CHUK | phosphorylation up-regulates → | NFKBIA PSer36 | phosphorylation down-regulates ⊣ | NFKBIA | 9346241 | SIGNOR-52879 |
| RPS6KA2 | phosphorylation up-regulates → | NFKBIA PSer32 | phosphorylation down-regulates ⊣ | NFKBIA | 20385620 | SIGNOR-164790 |
| IKK-complex | phosphorylation up-regulates → | NFKBIA PSer36 | phosphorylation down-regulates ⊣ | NFKBIA | 9346241 | SIGNOR-209773 |
| CSNK2A1 | phosphorylation up-regulates → | NFKBIA PSer36 | phosphorylation down-regulates ⊣ | NFKBIA | 10398585 | SIGNOR-249333 |
| RPS6KA3 | phosphorylation up-regulates → | NFKBIA PSer32 | phosphorylation down-regulates ⊣ | NFKBIA | 20385620 | SIGNOR-279108 |
| AURKC | phosphorylation up-regulates → | NFKBIA PSer32 | phosphorylation up-regulates → | NFKBIA | 29050234 | SIGNOR-278470 |
| CHUK | phosphorylation up-regulates → | NFKBIA PSer32 | phosphorylation down-regulates ⊣ | NFKBIA | 9346241 | SIGNOR-52875 |
| SRC | phosphorylation up-regulates → | NFKBIA PTyr42 | phosphorylation down-regulates ⊣ | NFKBIA | 9792645 | SIGNOR-60879 |
| CSNK2A1 | phosphorylation up-regulates → | NFKBIA PSer32 | phosphorylation down-regulates ⊣ | NFKBIA | 10398585 | SIGNOR-249332 |
| CSNK2A1 | phosphorylation up-regulates → | NFKBIA PSer293 | phosphorylation down-regulates ⊣ | NFKBIA | 8622692 | SIGNOR-40510 |
| EIF2AK2 | phosphorylation up-regulates → | NFKBIA PSer32 | phosphorylation down-regulates ⊣ | NFKBIA | 10723127 | SIGNOR-249335 |
| PTPN13 | dephosphorylation down-regulates ⊣ | NFKBIA PTyr42 | dephosphorylation down-regulates ⊣ | NFKBIA | 11106428 | SIGNOR-248712 |
| AURKA | phosphorylation up-regulates → | NFKBIA PSer32 | phosphorylation down-regulates ⊣ | NFKBIA | 23993973 | SIGNOR-278912 |
| IKBKE | phosphorylation up-regulates → | NFKBIA PSer36 | phosphorylation down-regulates ⊣ | NFKBIA | 11815618 | SIGNOR-249367 |
| IKBKB | phosphorylation up-regulates → | NFKBIA PSer32 | phosphorylation down-regulates ⊣ | NFKBIA | 11815618 | SIGNOR-249365 |
| TBK1 | phosphorylation up-regulates → | NFKBIA PSer36 | phosphorylation down-regulates ⊣ | NFKBIA | 11815618 | SIGNOR-246643 |
| LCK | phosphorylation up-regulates → | NFKBIA PTyr42 | phosphorylation down-regulates ⊣ | NFKBIA | 14534291 | SIGNOR-249374 |
| IKK-complex | phosphorylation up-regulates → | NFKBIA PSer36 | phosphorylation down-regulates ⊣ | NFKBIA | 9346241 | SIGNOR-216389 |
| IKBKB | phosphorylation up-regulates → | NFKBIA PSer36 | phosphorylation down-regulates ⊣ | NFKBIA | 11815618 | SIGNOR-249366 |
| RPS6KA1 | phosphorylation up-regulates → | NFKBIA PSer32 | phosphorylation up-regulates → | NFKBIA | 10398585 | SIGNOR-279311 |
| IKK-complex | phosphorylation up-regulates → | NFKBIA PSer32 | phosphorylation down-regulates ⊣ | NFKBIA | 9346241 | SIGNOR-216385 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK2A1 | phosphorylation down-regulates | NFKBIA | SIGNOR-40514 |
| PTPN1 | dephosphorylation down-regulates | NFKBIA | SIGNOR-45004 |
| CSNK2A1 | phosphorylation down-regulates | NFKBIA | SIGNOR-40506 |
| IKBKG | phosphorylation → down-regulates activity | NFKBIA | SIGNOR-280462 |
| CSNK2A1 | phosphorylation down-regulates | NFKBIA | SIGNOR-40502 |
| CHUK | phosphorylation down-regulates quantity by destabilization | NFKBIA | SIGNOR-52879 |
| RPS6KA2 | phosphorylation down-regulates | NFKBIA | SIGNOR-164790 |
| IKK-complex | phosphorylation down-regulates quantity by destabilization | NFKBIA | SIGNOR-209773 |
| CSNK2A1 | phosphorylation down-regulates quantity by destabilization | NFKBIA | SIGNOR-249333 |
| RPS6KA3 | phosphorylation down-regulates quantity by destabilization | NFKBIA | SIGNOR-279108 |
| AURKC | phosphorylation → up-regulates activity | NFKBIA | SIGNOR-278470 |
| IKBKE | phosphorylation down-regulates quantity by destabilization | NFKBIA | SIGNOR-167524 |
| CHUK | phosphorylation down-regulates quantity by destabilization | NFKBIA | SIGNOR-52875 |
| SRC | phosphorylation down-regulates quantity by destabilization | NFKBIA | SIGNOR-60879 |
| IKBKB | phosphorylation → down-regulates activity | NFKBIA | SIGNOR-235400 |
| CSNK2A1 | phosphorylation down-regulates quantity by destabilization | NFKBIA | SIGNOR-249332 |
| CSNK2A1 | phosphorylation down-regulates | NFKBIA | SIGNOR-40510 |
| EIF2AK2 | phosphorylation down-regulates quantity by destabilization | NFKBIA | SIGNOR-249335 |
| IKK-complex | phosphorylation down-regulates | NFKBIA | SIGNOR-216396 |
| PTPN13 | dephosphorylation → up-regulates quantity by stabilization | NFKBIA | SIGNOR-248712 |
| AURKA | phosphorylation → down-regulates activity | NFKBIA | SIGNOR-278912 |
| IKBKE | phosphorylation down-regulates quantity by destabilization | NFKBIA | SIGNOR-249367 |
| IKBKB | phosphorylation down-regulates quantity by destabilization | NFKBIA | SIGNOR-249365 |
| TBK1 | phosphorylation down-regulates quantity by destabilization | NFKBIA | SIGNOR-246643 |
| LCK | phosphorylation down-regulates quantity by destabilization | NFKBIA | SIGNOR-249374 |
| IKK-complex | phosphorylation down-regulates | NFKBIA | SIGNOR-216389 |
| IKBKB | phosphorylation down-regulates quantity by destabilization | NFKBIA | SIGNOR-249366 |
| RPS6KA1 | phosphorylation → up-regulates activity | NFKBIA | SIGNOR-279311 |
| IKK-complex | phosphorylation down-regulates | NFKBIA | SIGNOR-216385 |
