Summary

Name NFKBIA
Full Name NF-kappa-B inhibitor alpha
Synonyms I-kappa-B-alpha, IkB-alpha, IkappaBalpha, Major histocompatibility complex enhancer-binding protein MAD3 | IKBA, MAD3, NFKBI
Primary ID P25963
Links - -
Type protein
Relations 39
Pathways Toll like receptors, NF-KB Canonical, TNF alpha, IL1 Receptor, Inhibition of Apoptosis, T cell activation
Function Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png ubiquitination NFKBIA 0.30
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NFKBIA 0.29
Publications: 4 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NFKBIA 0.96
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NFKBIA 0.29
Publications: 2
+ down-regulates img/direct_inhibition.png phosphorylation NFKBIA
Publications: 3 Organism: Homo Sapiens
Pathways:IL1 Receptor, Inhibition of Apoptosis, NF-KB Canonical, TNF alpha, T cell activation, Toll like receptors
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NFKBIA 0.23
Publications: 1
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NFKBIA 0.90
Publications: 2
+ down-regulates img/direct_inhibition.png phosphorylation NFKBIA 0.18
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NFKBIA 0.33
Publications: 1 Organism: Homo Sapiens
Pathways:Toll like receptors
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NFKBIA
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Receptor, Inhibition of Apoptosis, NF-KB Canonical, TNF alpha, T cell activation, Toll like receptors
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NFKBIA 0.45
Publications: 2 Organism: , Homo Sapiens
Pathways:Toll like receptors
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NFKBIA 0.21
Publications: 1
Pathways:T cell activation
+ up-regulates img/direct-activation.png phosphorylation NFKBIA
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png dephosphorylation NFKBIA
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation NFKBIA 0.23
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/indirect_inhibition.png unknown NFKBIA 0.46
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Receptor, Inhibition of Apoptosis, NF-KB Canonical, Toll like receptors
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation S100A6 0.13
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding NfKb-p65/p50
Publications: 2 Organism: Homo Sapiens
Pathways:IL1 Receptor, Inhibition of Apoptosis, NF-KB Canonical, TNF alpha, T cell activation, Toll like receptors
+ down-regulates activity img/direct_inhibition.png phosphorylation NFKBIA 0.90
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by destabilization img/indirect_inhibition.png unknown NFKBIA 0.39
Publications: 1 Organism: Mus Musculus
Pathways:Inhibition of Apoptosis, NF-KB Canonical, TNF alpha
+ up-regulates quantity by stabilization img/direct-activation.png cleavage NFKBIA 0.19
Publications: 1 Organism: In Vitro
Pathways:Inhibition of Apoptosis, TNF alpha
+ down-regulates img/indirect_inhibition.png unknown NFKBIA
Publications: 1 Organism: Mus Musculus
Tissue: Muscle, Skeletal Muscle
+ down-regulates activity img/direct_inhibition.png binding NFKB1 0.89
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RELA 0.90
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png cleavage NFKBIA
Publications: 1 Organism: In Vitro
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NFKBIA 0.26
Publications: 1 Organism: Homo Sapiens