| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN1 | NFKBIA | Tyr42 | DSMKDEEyEQMVKEL | dephosphorylation down-regulates | 8940099 | SIGNOR-45004 |
| SRC | NFKBIA | Tyr42 | DSMKDEEyEQMVKEL | phosphorylation down-regulates quantity by destabilization | 9792645 | SIGNOR-60879 |
| PTPN13 | NFKBIA | Tyr42 | DSMKDEEyEQMVKEL | dephosphorylation up-regulates quantity by stabilization | 11106428 | SIGNOR-248712 |
| LCK | NFKBIA | Tyr42 | DSMKDEEyEQMVKEL | phosphorylation down-regulates quantity by destabilization | 14534291 | SIGNOR-249374 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN1 | dephosphorylation down-regulates ⊣ | NFKBIA PTyr42 | dephosphorylation up-regulates → | NFKBIA | 8940099 | SIGNOR-45004 |
| SRC | phosphorylation up-regulates → | NFKBIA PTyr42 | phosphorylation down-regulates ⊣ | NFKBIA | 9792645 | SIGNOR-60879 |
| PTPN13 | dephosphorylation down-regulates ⊣ | NFKBIA PTyr42 | dephosphorylation down-regulates ⊣ | NFKBIA | 11106428 | SIGNOR-248712 |
| LCK | phosphorylation up-regulates → | NFKBIA PTyr42 | phosphorylation down-regulates ⊣ | NFKBIA | 14534291 | SIGNOR-249374 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN1 | dephosphorylation down-regulates | NFKBIA | SIGNOR-45004 |
| SRC | phosphorylation down-regulates quantity by destabilization | NFKBIA | SIGNOR-60879 |
| PTPN13 | dephosphorylation → up-regulates quantity by stabilization | NFKBIA | SIGNOR-248712 |
| LCK | phosphorylation down-regulates quantity by destabilization | NFKBIA | SIGNOR-249374 |
