| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDC42BPB | MSN | Thr558 | LGRDKYKtLRQIRQG | phosphorylation up-regulates activity | 10947843 | SIGNOR-260802 |
| LRRK2 | MSN | Thr558 | LGRDKYKtLRQIRQG | phosphorylation up-regulates activity | 8537411 | SIGNOR-39433 |
| ROCK1 | MSN | Thr558 | LGRDKYKtLRQIRQG | phosphorylation up-regulates activity | 9856983 | SIGNOR-249014 |
| PRKCQ | MSN | Thr558 | LGRDKYKtLRQIRQG | phosphorylation unknown | 9856983 | SIGNOR-249013 |
| RHOA | MSN | Thr558 | LGRDKYKtLRQIRQG | phosphorylation up-regulates activity | 35267019 | SIGNOR-268431 |
| LRRK2 | MSN | Thr558 | LGRDKYKtLRQIRQG | phosphorylation up-regulates activity | 17447891 | SIGNOR-154498 |
| STK10 | MSN | Thr558 | LGRDKYKtLRQIRQG | phosphorylation up-regulates activity | 19255442 | SIGNOR-184433 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDC42BPB | phosphorylation up-regulates → | MSN PThr558 | phosphorylation up-regulates → | MSN | 10947843 | SIGNOR-260802 |
| LRRK2 | phosphorylation up-regulates → | MSN PThr558 | phosphorylation up-regulates → | MSN | 8537411 | SIGNOR-39433 |
| ROCK1 | phosphorylation up-regulates → | MSN PThr558 | phosphorylation up-regulates → | MSN | 9856983 | SIGNOR-249014 |
| PRKCQ | phosphorylation up-regulates → | MSN PThr558 | phosphorylation down-regulates ⊣ | MSN | 9856983 | SIGNOR-249013 |
| RHOA | phosphorylation up-regulates → | MSN PThr558 | phosphorylation up-regulates → | MSN | 35267019 | SIGNOR-268431 |
| LRRK2 | phosphorylation up-regulates → | MSN PThr558 | phosphorylation up-regulates → | MSN | 17447891 | SIGNOR-154498 |
| STK10 | phosphorylation up-regulates → | MSN PThr558 | phosphorylation up-regulates → | MSN | 19255442 | SIGNOR-184433 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDC42BPB | phosphorylation → up-regulates activity | MSN | SIGNOR-260802 |
| LRRK2 | phosphorylation → up-regulates activity | MSN | SIGNOR-39433 |
| ROCK1 | phosphorylation → up-regulates activity | MSN | SIGNOR-249014 |
| PRKCQ | phosphorylation → unknown | MSN | SIGNOR-249013 |
| RHOA | phosphorylation → up-regulates activity | MSN | SIGNOR-268431 |
| LRRK2 | phosphorylation → up-regulates activity | MSN | SIGNOR-154498 |
| STK10 | phosphorylation → up-regulates activity | MSN | SIGNOR-184433 |
