| Name | DNMT1 |
| ID | P26358 |
| Role | substrate |
| Enzymatic Domains |
DMAP1-binding 16-109 PROSITE-ProRule
BAH 1 755-880 PROSITE-ProRule
BAH 2 972-1100 PROSITE-ProRule
SAM-dependent MTase C5-type 1139-1599 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | DNMT1 | Ser143 | RTPRRSKsDGEAKPE | phosphorylation up-regulates | 21151116 | SIGNOR-170530 |
| CDK5 | DNMT1 | Ser154 | AKPEPSPsPRITRKS | phosphorylation up-regulates | 21565170 | SIGNOR-173685 |
| GSK3B | DNMT1 | – | phosphorylation down-regulates quantity | 20093774 | SIGNOR-279181 | |
| AKT | DNMT1 | Ser143 | RTPRRSKsDGEAKPE | phosphorylation up-regulates | 21151116 | SIGNOR-244232 |
| CDK2 | DNMT1 | Ser154 | AKPEPSPsPRITRKS | phosphorylation up-regulates | 21565170 | SIGNOR-173681 |
| CDK1 | DNMT1 | Ser154 | AKPEPSPsPRITRKS | phosphorylation up-regulates | 21565170 | SIGNOR-173677 |
| PRKAA1 | DNMT1 | Ser714 | DNIPEMPsPKKMHQG | phosphorylation down-regulates activity | 28143904 | SIGNOR-264783 |
| AMPK | DNMT1 | Ser714 | DNIPEMPsPKKMHQG | phosphorylation down-regulates activity | 28143904 | SIGNOR-264788 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | phosphorylation up-regulates → | DNMT1 PSer143 | phosphorylation up-regulates → | DNMT1 | 21151116 | SIGNOR-170530 |
| CDK5 | phosphorylation up-regulates → | DNMT1 PSer154 | phosphorylation up-regulates → | DNMT1 | 21565170 | SIGNOR-173685 |
| AKT | phosphorylation up-regulates → | DNMT1 PSer143 | phosphorylation up-regulates → | DNMT1 | 21151116 | SIGNOR-244232 |
| CDK2 | phosphorylation up-regulates → | DNMT1 PSer154 | phosphorylation up-regulates → | DNMT1 | 21565170 | SIGNOR-173681 |
| CDK1 | phosphorylation up-regulates → | DNMT1 PSer154 | phosphorylation up-regulates → | DNMT1 | 21565170 | SIGNOR-173677 |
| PRKAA1 | phosphorylation up-regulates → | DNMT1 PSer714 | phosphorylation down-regulates ⊣ | DNMT1 | 28143904 | SIGNOR-264783 |
| AMPK | phosphorylation up-regulates → | DNMT1 PSer714 | phosphorylation down-regulates ⊣ | DNMT1 | 28143904 | SIGNOR-264788 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT1 | phosphorylation → up-regulates | DNMT1 | SIGNOR-170530 |
| CDK5 | phosphorylation → up-regulates | DNMT1 | SIGNOR-173685 |
| GSK3B | phosphorylation → down-regulates quantity | DNMT1 | SIGNOR-279181 |
| AKT | phosphorylation → up-regulates | DNMT1 | SIGNOR-244232 |
| CDK2 | phosphorylation → up-regulates | DNMT1 | SIGNOR-173681 |
| CDK1 | phosphorylation → up-regulates | DNMT1 | SIGNOR-173677 |
| PRKAA1 | phosphorylation → down-regulates activity | DNMT1 | SIGNOR-264783 |
| AMPK | phosphorylation → down-regulates activity | DNMT1 | SIGNOR-264788 |