Summary

Name DNMT1
Full Name DNA
Synonyms Dnmt1, CXXC-type zinc finger protein 9, DNA methyltransferase HsaI, DNA MTase HsaI, M.HsaI, MCMT | AIM, CXXC9, DNMT
Primary ID P26358
Links - -
Type protein
Relations 25
Pathways Rett syndrome
Inhibitors 5-aza-2'-deoxycytidine; 5-azacytidine
Function Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation DNMT1 0.531
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DNMT1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DNMT1 0.36
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DNMT1 0.344
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DNMT1 0.301
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation DNMT1 0.288
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation DNMT1 0.2
Publications: 1 Organism: In Vitro
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ESR1 0.402
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation DNMT1 0.436
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BAG1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation DNMT1 0.441
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding DNMT1/DNMT3A 0.783
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation RELN 0.435
Publications: 1 Organism: Homo Sapiens
Pathways:Rett syndrome
+ down-regulates activity img/direct_inhibition.png chemical inhibition DNMT1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation DNMT1 0.786
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding DNMT1 0.568
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition DNMT1 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BAG3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BAG4 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation GAD1 0.35
Publications: 1 Organism: Homo Sapiens
Pathways:Rett syndrome
+ up-regulates activity img/direct-activation.png binding DNMT1 0.532
Publications: 1 Organism: Homo Sapiens
Pathways:Rett syndrome
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation IL32 0.343
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MBD2 0.704
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding DNMT1/DNMT3B 0.79
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation FOXP3 0.492
Publications: 1 Organism: Homo Sapiens