| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK2 | DNMT1 | Ser154 | AKPEPSPsPRITRKS | phosphorylation up-regulates | 21565170 | SIGNOR-173681 |
| CDK1 | DNMT1 | Ser154 | AKPEPSPsPRITRKS | phosphorylation up-regulates | 21565170 | SIGNOR-173677 |
| CDK5 | DNMT1 | Ser154 | AKPEPSPsPRITRKS | phosphorylation up-regulates | 21565170 | SIGNOR-173685 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK2 | phosphorylation up-regulates → | DNMT1 PSer154 | phosphorylation up-regulates → | DNMT1 | 21565170 | SIGNOR-173681 |
| CDK1 | phosphorylation up-regulates → | DNMT1 PSer154 | phosphorylation up-regulates → | DNMT1 | 21565170 | SIGNOR-173677 |
| CDK5 | phosphorylation up-regulates → | DNMT1 PSer154 | phosphorylation up-regulates → | DNMT1 | 21565170 | SIGNOR-173685 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK2 | phosphorylation → up-regulates | DNMT1 | SIGNOR-173681 |
| CDK1 | phosphorylation → up-regulates | DNMT1 | SIGNOR-173677 |
| CDK5 | phosphorylation → up-regulates | DNMT1 | SIGNOR-173685 |