| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AMPK | DNMT1 | Ser714 | DNIPEMPsPKKMHQG | phosphorylation down-regulates activity | 28143904 | SIGNOR-264788 |
| PRKAA1 | DNMT1 | Ser714 | DNIPEMPsPKKMHQG | phosphorylation down-regulates activity | 28143904 | SIGNOR-264783 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AMPK | phosphorylation up-regulates → | DNMT1 PSer714 | phosphorylation down-regulates ⊣ | DNMT1 | 28143904 | SIGNOR-264788 |
| PRKAA1 | phosphorylation up-regulates → | DNMT1 PSer714 | phosphorylation down-regulates ⊣ | DNMT1 | 28143904 | SIGNOR-264783 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AMPK | phosphorylation → down-regulates activity | DNMT1 | SIGNOR-264788 |
| PRKAA1 | phosphorylation → down-regulates activity | DNMT1 | SIGNOR-264783 |