| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| HIPK2 | PAX6 | Thr304 | QPIPQPTtPVSSFTS | phosphorylation up-regulates activity | 16407227 | SIGNOR-251270 |
| HIPK2 | PAX6 | Thr281 | QRRQASNtPSHIPIS | phosphorylation up-regulates activity | 16407227 | SIGNOR-251269 |
| HIPK2 | PAX6 | Thr373 | GRSYDTYtPPHMQTH | phosphorylation up-regulates activity | 16407227 | SIGNOR-251271 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| HIPK2 | phosphorylation up-regulates → | PAX6 PThr304 | phosphorylation up-regulates → | PAX6 | 16407227 | SIGNOR-251270 |
| HIPK2 | phosphorylation up-regulates → | PAX6 PThr281 | phosphorylation up-regulates → | PAX6 | 16407227 | SIGNOR-251269 |
| HIPK2 | phosphorylation up-regulates → | PAX6 PThr373 | phosphorylation up-regulates → | PAX6 | 16407227 | SIGNOR-251271 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| HIPK2 | phosphorylation → up-regulates activity | PAX6 | SIGNOR-251270 |
| HIPK2 | phosphorylation → up-regulates activity | PAX6 | SIGNOR-251269 |
| HIPK2 | phosphorylation → up-regulates activity | PAX6 | SIGNOR-251271 |