Summary

Name PAX6
Full Name Paired box protein Pax-6
Synonyms Aniridia type II protein, Oculorhombin | AN2
Primary ID P26367
Links - -
Type protein
Relations 13
Function Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation PAX6 0.32
Publications: 3 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CTNND2
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PAX6
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PAX6 0.16
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PAX6
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding PAX6 0.41
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GCG 0.11
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding CDX2/PAX6/P300
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PCSK1 0.25
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PAX6 0.02
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding PAX6 0.26
Publications: 1 Organism: Homo Sapiens