| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | PLN | Thr17 | SAIRRAStIEMPQQA | phosphorylation down-regulates activity | 19696029 | SIGNOR-252035 |
| PRKG1 | PLN | Ser16 | RSAIRRAsTIEMPQQ | phosphorylation up-regulates activity | 22199120 | SIGNOR-279269 |
| DMPK | PLN | – | phosphorylation up-regulates | 15598648 | SIGNOR-131371 | |
| AKT1 | PLN | Thr17 | SAIRRAStIEMPQQA | phosphorylation down-regulates activity | 19696029 | SIGNOR-252578 |
| PRKACA | PLN | Ser16 | RSAIRRAsTIEMPQQ | phosphorylation up-regulates activity | 10988285 | SIGNOR-250030 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | phosphorylation up-regulates → | PLN PThr17 | phosphorylation down-regulates ⊣ | PLN | 19696029 | SIGNOR-252035 |
| PRKG1 | phosphorylation up-regulates → | PLN PSer16 | phosphorylation up-regulates → | PLN | 22199120 | SIGNOR-279269 |
| AKT1 | phosphorylation up-regulates → | PLN PThr17 | phosphorylation down-regulates ⊣ | PLN | 19696029 | SIGNOR-252578 |
| PRKACA | phosphorylation up-regulates → | PLN PSer16 | phosphorylation up-regulates → | PLN | 10988285 | SIGNOR-250030 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT | phosphorylation → down-regulates activity | PLN | SIGNOR-252035 |
| PRKG1 | phosphorylation → up-regulates activity | PLN | SIGNOR-279269 |
| DMPK | phosphorylation → up-regulates | PLN | SIGNOR-131371 |
| AKT1 | phosphorylation → down-regulates activity | PLN | SIGNOR-252578 |
| PRKACA | phosphorylation → up-regulates activity | PLN | SIGNOR-250030 |
