4.0
Summary
| Name |  PLNView Modifications |
| Full Name | Cardiac phospholamban |
| Synonyms | PLB | PLB |
| Primary ID | P26678 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Function | Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+) (PubMed:28890335). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKACA | up-regulates activity 
phosphorylation
|
PLN | 0.491 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | PRKG1 | up-regulates activity
phosphorylation
|
PLN | 0.409 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AKT | down-regulates activity 
phosphorylation
|
PLN | 0.2 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | AKT1 | down-regulates activity
phosphorylation
|
PLN | 0.289 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | PLN | down-regulates activity
binding
|
ATP2A2 | 0.751 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | DMPK | up-regulates
phosphorylation
|
PLN | 0.54 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Muscle | |||