| Name | MAPK3 |
| ID | P27361 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 42-330 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP2K1 | MAPK3 | Tyr204 | HTGFLTEyVATRWYR | phosphorylation up-regulates | 9677429 | SIGNOR-59157 |
| LCK | MAPK3 | Tyr204 | HTGFLTEyVATRWYR | phosphorylation up-regulates | 17998336 | SIGNOR-159168 |
| PTPRJ | MAPK3 | – | dephosphorylation down-regulates | 12771128 | SIGNOR-101282 | |
| DUSP5 | MAPK3 | – | dephosphorylation down-regulates | 10224087 | SIGNOR-67358 | |
| MAPK3 | MAPK3 | Thr202 | HDHTGFLtEYVATRW | phosphorylation up-regulates activity | 1712480 | SIGNOR-249471 |
| MAP2K2 | MAPK3 | Tyr204 | HTGFLTEyVATRWYR | phosphorylation up-regulates | 1411546 | SIGNOR-19244 |
| PPP2CA | MAPK3 | – | dephosphorylation down-regulates | 12840032 | SIGNOR-103162 | |
| PTPRJ | MAPK3 | Tyr204 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 19494114 | SIGNOR-248707 |
| MAPK3 | MAPK3 | Tyr204 | HTGFLTEyVATRWYR | phosphorylation up-regulates activity | 1712480 | SIGNOR-249472 |
| MAP2K1 | MAPK3 | Thr202 | HDHTGFLtEYVATRW | phosphorylation up-regulates | 9677429 | SIGNOR-59153 |
| MAP2K1 | MAPK3 | – | phosphorylation up-regulates | 12270934 | SIGNOR-210176 | |
| DUSP1 | MAPK3 | Thr202 | HDHTGFLtEYVATRW | dephosphorylation down-regulates activity | 7535768 | SIGNOR-248462 |
| DUSP1 | MAPK3 | – | dephosphorylation down-regulates | 10617468 | SIGNOR-73617 | |
| MAP2K2 | MAPK3 | – | phosphorylation up-regulates activity | 11730323 | SIGNOR-258997 | |
| RET | MAPK3 | Tyr204 | HTGFLTEyVATRWYR | phosphorylation up-regulates | 16153436 | SIGNOR-140298 |
| PP1 | MAPK3 | – | dephosphorylation down-regulates | 12840032 | SIGNOR-264665 | |
| MAPK3 | MAPK3 | Thr207 | FLTEYVAtRWYRAPE | phosphorylation up-regulates activity | 19060905 | SIGNOR-182628 |
| DUSP3 | MAPK3 | Tyr204 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 12840032 | SIGNOR-103035 |
| MEK1/2 | MAPK3 | Tyr204 | HTGFLTEyVATRWYR | phosphorylation up-regulates | 9677429 | SIGNOR-244806 |
| DUSP23 | MAPK3 | – | dephosphorylation down-regulates activity | 27281782 | SIGNOR-277103 | |
| DUSP4 | MAPK3 | Tyr204 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 7535768 | SIGNOR-248716 |
| DUSP6 | MAPK3 | – | dephosphorylation down-regulates | 12840032 | SIGNOR-103149 | |
| MEK1/2 | MAPK3 | – | phosphorylation up-regulates activity | 11730323 | SIGNOR-258991 | |
| PTPRB | MAPK3 | – | dephosphorylation up-regulates | 12840032 | SIGNOR-103165 | |
| PPP1CA | MAPK3 | – | dephosphorylation down-regulates | 12840032 | SIGNOR-103155 | |
| DUSP4 | MAPK3 | Thr202 | HDHTGFLtEYVATRW | dephosphorylation down-regulates activity | 7535768 | SIGNOR-248715 |
| DUSP3 | MAPK3 | Tyr204 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 10224087 | SIGNOR-248535 |
| MEK1/2 | MAPK3 | – | phosphorylation up-regulates | 12270934 | SIGNOR-244798 | |
| MEK1/2 | MAPK3 | Thr202 | HDHTGFLtEYVATRW | phosphorylation up-regulates | 9677429 | SIGNOR-244802 |
| MAP2K1 | MAPK3 | – | phosphorylation up-regulates activity | 11730323 | SIGNOR-258994 | |
| ERK1/2 | MAPK3 | Thr207 | FLTEYVAtRWYRAPE | phosphorylation up-regulates activity | 19060905 | SIGNOR-244565 |
| CDC25A | MAPK3 | – | dephosphorylation down-regulates | 15672448 | SIGNOR-133392 | |
| MAP2K2 | MAPK3 | Thr202 | HDHTGFLtEYVATRW | phosphorylation up-regulates | 1411546 | SIGNOR-19240 |
| DUSP1 | MAPK3 | Tyr204 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 7535768 | SIGNOR-248463 |
| PPP2CA | MAPK3 | Thr202 | HDHTGFLtEYVATRW | dephosphorylation down-regulates | 16456541 | SIGNOR-144322 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP2K1 | phosphorylation up-regulates → | MAPK3 PTyr204 | phosphorylation up-regulates → | MAPK3 | 9677429 | SIGNOR-59157 |
| LCK | phosphorylation up-regulates → | MAPK3 PTyr204 | phosphorylation up-regulates → | MAPK3 | 17998336 | SIGNOR-159168 |
| MAPK3 | phosphorylation up-regulates → | MAPK3 PThr202 | phosphorylation up-regulates → | MAPK3 | 1712480 | SIGNOR-249471 |
| MAP2K2 | phosphorylation up-regulates → | MAPK3 PTyr204 | phosphorylation up-regulates → | MAPK3 | 1411546 | SIGNOR-19244 |
| PTPRJ | dephosphorylation down-regulates ⊣ | MAPK3 PTyr204 | dephosphorylation up-regulates → | MAPK3 | 19494114 | SIGNOR-248707 |
| MAPK3 | phosphorylation up-regulates → | MAPK3 PTyr204 | phosphorylation up-regulates → | MAPK3 | 1712480 | SIGNOR-249472 |
| MAP2K1 | phosphorylation up-regulates → | MAPK3 PThr202 | phosphorylation up-regulates → | MAPK3 | 9677429 | SIGNOR-59153 |
| DUSP1 | dephosphorylation down-regulates ⊣ | MAPK3 PThr202 | dephosphorylation up-regulates → | MAPK3 | 7535768 | SIGNOR-248462 |
| RET | phosphorylation up-regulates → | MAPK3 PTyr204 | phosphorylation up-regulates → | MAPK3 | 16153436 | SIGNOR-140298 |
| MAPK3 | phosphorylation up-regulates → | MAPK3 PThr207 | phosphorylation up-regulates → | MAPK3 | 19060905 | SIGNOR-182628 |
| DUSP3 | dephosphorylation down-regulates ⊣ | MAPK3 PTyr204 | dephosphorylation up-regulates → | MAPK3 | 12840032 | SIGNOR-103035 |
| MEK1/2 | phosphorylation up-regulates → | MAPK3 PTyr204 | phosphorylation up-regulates → | MAPK3 | 9677429 | SIGNOR-244806 |
| DUSP4 | dephosphorylation down-regulates ⊣ | MAPK3 PTyr204 | dephosphorylation up-regulates → | MAPK3 | 7535768 | SIGNOR-248716 |
| DUSP4 | dephosphorylation down-regulates ⊣ | MAPK3 PThr202 | dephosphorylation up-regulates → | MAPK3 | 7535768 | SIGNOR-248715 |
| DUSP3 | dephosphorylation down-regulates ⊣ | MAPK3 PTyr204 | dephosphorylation up-regulates → | MAPK3 | 10224087 | SIGNOR-248535 |
| MEK1/2 | phosphorylation up-regulates → | MAPK3 PThr202 | phosphorylation up-regulates → | MAPK3 | 9677429 | SIGNOR-244802 |
| ERK1/2 | phosphorylation up-regulates → | MAPK3 PThr207 | phosphorylation up-regulates → | MAPK3 | 19060905 | SIGNOR-244565 |
| MAP2K2 | phosphorylation up-regulates → | MAPK3 PThr202 | phosphorylation up-regulates → | MAPK3 | 1411546 | SIGNOR-19240 |
| DUSP1 | dephosphorylation down-regulates ⊣ | MAPK3 PTyr204 | dephosphorylation up-regulates → | MAPK3 | 7535768 | SIGNOR-248463 |
| PPP2CA | dephosphorylation down-regulates ⊣ | MAPK3 PThr202 | dephosphorylation up-regulates → | MAPK3 | 16456541 | SIGNOR-144322 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAP2K1 | phosphorylation → up-regulates | MAPK3 | SIGNOR-59157 |
| LCK | phosphorylation → up-regulates | MAPK3 | SIGNOR-159168 |
| PTPRJ | dephosphorylation down-regulates | MAPK3 | SIGNOR-101282 |
| DUSP5 | dephosphorylation down-regulates | MAPK3 | SIGNOR-67358 |
| MAPK3 | phosphorylation → up-regulates activity | MAPK3 | SIGNOR-249471 |
| MAP2K2 | phosphorylation → up-regulates | MAPK3 | SIGNOR-19244 |
| PPP2CA | dephosphorylation down-regulates | MAPK3 | SIGNOR-103162 |
| PTPRJ | dephosphorylation → down-regulates activity | MAPK3 | SIGNOR-248707 |
| MAPK3 | phosphorylation → up-regulates activity | MAPK3 | SIGNOR-249472 |
| MAP2K1 | phosphorylation → up-regulates | MAPK3 | SIGNOR-59153 |
| MAP2K1 | phosphorylation → up-regulates | MAPK3 | SIGNOR-210176 |
| DUSP1 | dephosphorylation → down-regulates activity | MAPK3 | SIGNOR-248462 |
| DUSP1 | dephosphorylation down-regulates | MAPK3 | SIGNOR-73617 |
| MAP2K2 | phosphorylation → up-regulates activity | MAPK3 | SIGNOR-258997 |
| RET | phosphorylation → up-regulates | MAPK3 | SIGNOR-140298 |
| PP1 | dephosphorylation down-regulates | MAPK3 | SIGNOR-264665 |
| MAPK3 | phosphorylation → up-regulates activity | MAPK3 | SIGNOR-182628 |
| DUSP3 | dephosphorylation → down-regulates activity | MAPK3 | SIGNOR-103035 |
| MEK1/2 | phosphorylation → up-regulates | MAPK3 | SIGNOR-244806 |
| DUSP23 | dephosphorylation → down-regulates activity | MAPK3 | SIGNOR-277103 |
| DUSP4 | dephosphorylation → down-regulates activity | MAPK3 | SIGNOR-248716 |
| DUSP6 | dephosphorylation down-regulates | MAPK3 | SIGNOR-103149 |
| MEK1/2 | phosphorylation → up-regulates activity | MAPK3 | SIGNOR-258991 |
| PTPRB | dephosphorylation → up-regulates | MAPK3 | SIGNOR-103165 |
| PPP1CA | dephosphorylation down-regulates | MAPK3 | SIGNOR-103155 |
| DUSP4 | dephosphorylation → down-regulates activity | MAPK3 | SIGNOR-248715 |
| DUSP3 | dephosphorylation → down-regulates activity | MAPK3 | SIGNOR-248535 |
| MEK1/2 | phosphorylation → up-regulates | MAPK3 | SIGNOR-244798 |
| MEK1/2 | phosphorylation → up-regulates | MAPK3 | SIGNOR-244802 |
| MAP2K1 | phosphorylation → up-regulates activity | MAPK3 | SIGNOR-258994 |
| ERK1/2 | phosphorylation → up-regulates activity | MAPK3 | SIGNOR-244565 |
| CDC25A | dephosphorylation down-regulates | MAPK3 | SIGNOR-133392 |
| MAP2K2 | phosphorylation → up-regulates | MAPK3 | SIGNOR-19240 |
| DUSP1 | dephosphorylation → down-regulates activity | MAPK3 | SIGNOR-248463 |
| PPP2CA | dephosphorylation down-regulates | MAPK3 | SIGNOR-144322 |