| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRJ | MAPK3 | Tyr204 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 19494114 | SIGNOR-248707 |
| MAPK3 | MAPK3 | Tyr204 | HTGFLTEyVATRWYR | phosphorylation up-regulates activity | 1712480 | SIGNOR-249472 |
| RET | MAPK3 | Tyr204 | HTGFLTEyVATRWYR | phosphorylation up-regulates | 16153436 | SIGNOR-140298 |
| DUSP3 | MAPK3 | Tyr204 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 12840032 | SIGNOR-103035 |
| MEK1/2 | MAPK3 | Tyr204 | HTGFLTEyVATRWYR | phosphorylation up-regulates | 9677429 | SIGNOR-244806 |
| DUSP4 | MAPK3 | Tyr204 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 7535768 | SIGNOR-248716 |
| DUSP3 | MAPK3 | Tyr204 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 10224087 | SIGNOR-248535 |
| DUSP1 | MAPK3 | Tyr204 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 7535768 | SIGNOR-248463 |
| MAP2K1 | MAPK3 | Tyr204 | HTGFLTEyVATRWYR | phosphorylation up-regulates | 9677429 | SIGNOR-59157 |
| LCK | MAPK3 | Tyr204 | HTGFLTEyVATRWYR | phosphorylation up-regulates | 17998336 | SIGNOR-159168 |
| MAP2K2 | MAPK3 | Tyr204 | HTGFLTEyVATRWYR | phosphorylation up-regulates | 1411546 | SIGNOR-19244 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRJ | dephosphorylation down-regulates ⊣ | MAPK3 PTyr204 | dephosphorylation up-regulates → | MAPK3 | 19494114 | SIGNOR-248707 |
| MAPK3 | phosphorylation up-regulates → | MAPK3 PTyr204 | phosphorylation up-regulates → | MAPK3 | 1712480 | SIGNOR-249472 |
| RET | phosphorylation up-regulates → | MAPK3 PTyr204 | phosphorylation up-regulates → | MAPK3 | 16153436 | SIGNOR-140298 |
| DUSP3 | dephosphorylation down-regulates ⊣ | MAPK3 PTyr204 | dephosphorylation up-regulates → | MAPK3 | 12840032 | SIGNOR-103035 |
| MEK1/2 | phosphorylation up-regulates → | MAPK3 PTyr204 | phosphorylation up-regulates → | MAPK3 | 9677429 | SIGNOR-244806 |
| DUSP4 | dephosphorylation down-regulates ⊣ | MAPK3 PTyr204 | dephosphorylation up-regulates → | MAPK3 | 7535768 | SIGNOR-248716 |
| DUSP3 | dephosphorylation down-regulates ⊣ | MAPK3 PTyr204 | dephosphorylation up-regulates → | MAPK3 | 10224087 | SIGNOR-248535 |
| DUSP1 | dephosphorylation down-regulates ⊣ | MAPK3 PTyr204 | dephosphorylation up-regulates → | MAPK3 | 7535768 | SIGNOR-248463 |
| MAP2K1 | phosphorylation up-regulates → | MAPK3 PTyr204 | phosphorylation up-regulates → | MAPK3 | 9677429 | SIGNOR-59157 |
| LCK | phosphorylation up-regulates → | MAPK3 PTyr204 | phosphorylation up-regulates → | MAPK3 | 17998336 | SIGNOR-159168 |
| MAP2K2 | phosphorylation up-regulates → | MAPK3 PTyr204 | phosphorylation up-regulates → | MAPK3 | 1411546 | SIGNOR-19244 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRJ | dephosphorylation → down-regulates activity | MAPK3 | SIGNOR-248707 |
| MAPK3 | phosphorylation → up-regulates activity | MAPK3 | SIGNOR-249472 |
| RET | phosphorylation → up-regulates | MAPK3 | SIGNOR-140298 |
| DUSP3 | dephosphorylation → down-regulates activity | MAPK3 | SIGNOR-103035 |
| MEK1/2 | phosphorylation → up-regulates | MAPK3 | SIGNOR-244806 |
| DUSP4 | dephosphorylation → down-regulates activity | MAPK3 | SIGNOR-248716 |
| DUSP3 | dephosphorylation → down-regulates activity | MAPK3 | SIGNOR-248535 |
| DUSP1 | dephosphorylation → down-regulates activity | MAPK3 | SIGNOR-248463 |
| MAP2K1 | phosphorylation → up-regulates | MAPK3 | SIGNOR-59157 |
| LCK | phosphorylation → up-regulates | MAPK3 | SIGNOR-159168 |
| MAP2K2 | phosphorylation → up-regulates | MAPK3 | SIGNOR-19244 |
