| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DUSP4 | MAPK3 | Thr202 | HDHTGFLtEYVATRW | dephosphorylation down-regulates activity | 7535768 | SIGNOR-248715 |
| MEK1/2 | MAPK3 | Thr202 | HDHTGFLtEYVATRW | phosphorylation up-regulates | 9677429 | SIGNOR-244802 |
| MAP2K2 | MAPK3 | Thr202 | HDHTGFLtEYVATRW | phosphorylation up-regulates | 1411546 | SIGNOR-19240 |
| PPP2CA | MAPK3 | Thr202 | HDHTGFLtEYVATRW | dephosphorylation down-regulates | 16456541 | SIGNOR-144322 |
| MAPK3 | MAPK3 | Thr202 | HDHTGFLtEYVATRW | phosphorylation up-regulates activity | 1712480 | SIGNOR-249471 |
| MAP2K1 | MAPK3 | Thr202 | HDHTGFLtEYVATRW | phosphorylation up-regulates | 9677429 | SIGNOR-59153 |
| DUSP1 | MAPK3 | Thr202 | HDHTGFLtEYVATRW | dephosphorylation down-regulates activity | 7535768 | SIGNOR-248462 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DUSP4 | dephosphorylation down-regulates ⊣ | MAPK3 PThr202 | dephosphorylation up-regulates → | MAPK3 | 7535768 | SIGNOR-248715 |
| MEK1/2 | phosphorylation up-regulates → | MAPK3 PThr202 | phosphorylation up-regulates → | MAPK3 | 9677429 | SIGNOR-244802 |
| MAP2K2 | phosphorylation up-regulates → | MAPK3 PThr202 | phosphorylation up-regulates → | MAPK3 | 1411546 | SIGNOR-19240 |
| PPP2CA | dephosphorylation down-regulates ⊣ | MAPK3 PThr202 | dephosphorylation up-regulates → | MAPK3 | 16456541 | SIGNOR-144322 |
| MAPK3 | phosphorylation up-regulates → | MAPK3 PThr202 | phosphorylation up-regulates → | MAPK3 | 1712480 | SIGNOR-249471 |
| MAP2K1 | phosphorylation up-regulates → | MAPK3 PThr202 | phosphorylation up-regulates → | MAPK3 | 9677429 | SIGNOR-59153 |
| DUSP1 | dephosphorylation down-regulates ⊣ | MAPK3 PThr202 | dephosphorylation up-regulates → | MAPK3 | 7535768 | SIGNOR-248462 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| DUSP4 | dephosphorylation → down-regulates activity | MAPK3 | SIGNOR-248715 |
| MEK1/2 | phosphorylation → up-regulates | MAPK3 | SIGNOR-244802 |
| MAP2K2 | phosphorylation → up-regulates | MAPK3 | SIGNOR-19240 |
| PPP2CA | dephosphorylation down-regulates | MAPK3 | SIGNOR-144322 |
| MAPK3 | phosphorylation → up-regulates activity | MAPK3 | SIGNOR-249471 |
| MAP2K1 | phosphorylation → up-regulates | MAPK3 | SIGNOR-59153 |
| DUSP1 | dephosphorylation → down-regulates activity | MAPK3 | SIGNOR-248462 |
