Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
MARK3	CDC25B	Ser323	QRLFRSPsMPCSVIR	phosphorylation down-regulates activity	35017636	SIGNOR-279224
MARK3	CDC25B	Ser323	QRLFRSPsMPCSVIR	phosphorylation up-regulates activity	35017636	SIGNOR-279223
MARK3	CDC25C	Ser216	SGLYRSPsMPENLNR	phosphorylation down-regulates activity	9543386	SIGNOR-250176
MARK3	TNK1	Ser502	RMKGISRsLESVLSL	phosphorylation down-regulates activity	34504101	SIGNOR-273868
MARK3	KSR1	Ser406	TRLRRTEsVPSDINN	phosphorylation down-regulates activity	22206009	SIGNOR-279225
MARK3	ARHGEF2	Ser151	LSLAKSVsTTNIAGH	phosphorylation up-regulates activity	29089450	SIGNOR-277368

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
MARK3	phosphorylation up-regulates →	CDC25B PSer323	phosphorylation down-regulates ⊣	CDC25B	35017636	SIGNOR-279224
MARK3	phosphorylation up-regulates →	CDC25B PSer323	phosphorylation up-regulates →	CDC25B	35017636	SIGNOR-279223
MARK3	phosphorylation up-regulates →	CDC25C PSer216	phosphorylation down-regulates ⊣	CDC25C	9543386	SIGNOR-250176
MARK3	phosphorylation up-regulates →	TNK1 PSer502	phosphorylation down-regulates ⊣	TNK1	34504101	SIGNOR-273868
MARK3	phosphorylation up-regulates →	KSR1 PSer406	phosphorylation down-regulates ⊣	KSR1	22206009	SIGNOR-279225
MARK3	phosphorylation up-regulates →	ARHGEF2 PSer151	phosphorylation up-regulates →	ARHGEF2	29089450	SIGNOR-277368

Regulator	Mechanism/Effect	Target	SIGNOR-ID
MARK3	phosphorylation → down-regulates activity	CDC25B	SIGNOR-279224
MARK3	phosphorylation → up-regulates activity	CDC25B	SIGNOR-279223
MARK3	phosphorylation → down-regulates activity	CDC25C	SIGNOR-250176
MARK3	phosphorylation → down-regulates activity	TNK1	SIGNOR-273868
MARK3	phosphorylation → down-regulates activity	KSR1	SIGNOR-279225
MARK3	phosphorylation → up-regulates activity	ARHGEF2	SIGNOR-277368