3.0
Summary
| Name |  MARK3View Modifications |
| Full Name | MAP/microtubule affinity-regulating kinase 3 |
| Synonyms | C-TAK1, cTAK1, Cdc25C-associated protein kinase 1, ELKL motif kinase 2, EMK-2, Protein kinase STK10, Ser/Thr protein kinase PAR-1, Par-1a, Serine/threonine-protein kinase p78 | CTAK1, EMK2 |
| Primary ID | P27448 |
| Links |  -  -  |
| Type | protein |
| Relations | 11 |
| Function | Serine/threonine-protein kinase (PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | STK11 | up-regulates activity 
phosphorylation
|
MARK3 | 0.322 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | MARK3 | down-regulates activity 
phosphorylation
|
CDC25C | 0.503 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | MARK3 | down-regulates activity
phosphorylation
|
TNK1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PIM | down-regulates
phosphorylation
|
MARK3 | 0.2 |
| Publications: | 3 | Organism: | Homo Sapiens | |
| + | PIM1 | down-regulates
phosphorylation
|
MARK3 | 0.428 |
| Publications: | 3 | Organism: | Homo Sapiens | |
| + | PRKCZ | down-regulates
phosphorylation
|
MARK3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |