| Name | MARK3 |
| ID | P27448 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 56-307 PROSITE-ProRule
UBA 326-365 PROSITE-ProRule
KA1 704-753 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| STK11 | MARK3 | Ser215 | KLDTFCGsPPYAAPE | phosphorylation up-regulates activity | 12879020 | SIGNOR-104059 |
| PIM | MARK3 | Thr95 | DKTQLNPtSLQKLFR | phosphorylation down-regulates | 15319445 | SIGNOR-259430 |
| PIM1 | MARK3 | Thr90 | AIKIIDKtQLNPTSL | phosphorylation down-regulates | 15319445 | SIGNOR-128264 |
| PRKCZ | MARK3 | Thr564 | RGTASRStFHGQPRE | phosphorylation down-regulates | 15084291 | SIGNOR-124221 |
| PIM | MARK3 | Thr90 | AIKIIDKtQLNPTSL | phosphorylation down-regulates | 15319445 | SIGNOR-259431 |
| PIM1 | MARK3 | Thr95 | DKTQLNPtSLQKLFR | phosphorylation down-regulates | 15319445 | SIGNOR-128268 |
| STK11 | MARK3 | Thr211 | TVGGKLDtFCGSPPY | phosphorylation up-regulates activity | 12879020 | SIGNOR-104063 |
| PIM | MARK3 | Ser96 | KTQLNPTsLQKLFRE | phosphorylation down-regulates | 15319445 | SIGNOR-259432 |
| PIM1 | MARK3 | Ser96 | KTQLNPTsLQKLFRE | phosphorylation down-regulates | 15319445 | SIGNOR-128260 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| STK11 | phosphorylation up-regulates → | MARK3 PSer215 | phosphorylation up-regulates → | MARK3 | 12879020 | SIGNOR-104059 |
| PIM | phosphorylation up-regulates → | MARK3 PThr95 | phosphorylation down-regulates ⊣ | MARK3 | 15319445 | SIGNOR-259430 |
| PIM1 | phosphorylation up-regulates → | MARK3 PThr90 | phosphorylation down-regulates ⊣ | MARK3 | 15319445 | SIGNOR-128264 |
| PRKCZ | phosphorylation up-regulates → | MARK3 PThr564 | phosphorylation down-regulates ⊣ | MARK3 | 15084291 | SIGNOR-124221 |
| PIM | phosphorylation up-regulates → | MARK3 PThr90 | phosphorylation down-regulates ⊣ | MARK3 | 15319445 | SIGNOR-259431 |
| PIM1 | phosphorylation up-regulates → | MARK3 PThr95 | phosphorylation down-regulates ⊣ | MARK3 | 15319445 | SIGNOR-128268 |
| STK11 | phosphorylation up-regulates → | MARK3 PThr211 | phosphorylation up-regulates → | MARK3 | 12879020 | SIGNOR-104063 |
| PIM | phosphorylation up-regulates → | MARK3 PSer96 | phosphorylation down-regulates ⊣ | MARK3 | 15319445 | SIGNOR-259432 |
| PIM1 | phosphorylation up-regulates → | MARK3 PSer96 | phosphorylation down-regulates ⊣ | MARK3 | 15319445 | SIGNOR-128260 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| STK11 | phosphorylation → up-regulates activity | MARK3 | SIGNOR-104059 |
| PIM | phosphorylation down-regulates | MARK3 | SIGNOR-259430 |
| PIM1 | phosphorylation down-regulates | MARK3 | SIGNOR-128264 |
| PRKCZ | phosphorylation down-regulates | MARK3 | SIGNOR-124221 |
| PIM | phosphorylation down-regulates | MARK3 | SIGNOR-259431 |
| PIM1 | phosphorylation down-regulates | MARK3 | SIGNOR-128268 |
| STK11 | phosphorylation → up-regulates activity | MARK3 | SIGNOR-104063 |
| PIM | phosphorylation down-regulates | MARK3 | SIGNOR-259432 |
| PIM1 | phosphorylation down-regulates | MARK3 | SIGNOR-128260 |