| Name | PIK3R1 |
| ID | P27986 |
| Role | substrate |
| Enzymatic Domains |
SH3 3-79 PROSITE-ProRule
Rho-GAP 113-301 PROSITE-ProRule
SH2 1 333-428 PROSITE-ProRule
SH2 2 624-718 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LCK | PIK3R1 | Tyr688 | FAEPYNLySSLKELV | phosphorylation down-regulates activity | 9461588 | SIGNOR-251383 |
| INSR | PIK3R1 | Tyr580 | LRKTRDQyLMWLTQK | phosphorylation up-regulates activity | 8385099 | SIGNOR-251321 |
| PPM1A | PIK3R1 | Ser608 | ENTEDQYsLVEDDED | dephosphorylation up-regulates activity | 15016818 | SIGNOR-248489 |
| PRKD1 | PIK3R1 | Ser154 | STLYRTQsSSNLAEL | phosphorylation up-regulates activity | 23129748 | SIGNOR-276426 |
| INSR | PIK3R1 | Tyr368 | STKMHGDyTLTLRKG | phosphorylation up-regulates activity | 8385099 | SIGNOR-251320 |
| SIK2 | PIK3R1 | Ser154 | STLYRTQsSSNLAEL | phosphorylation up-regulates activity | 27478041 | SIGNOR-277269 |
| PIK3CA | PIK3R1 | Ser608 | ENTEDQYsLVEDDED | phosphorylation up-regulates activity | 14729945 | SIGNOR-276004 |
| PKA | PIK3R1 | Ser83 | YIGRKKIsPPTPKPR | phosphorylation up-regulates activity | 21743495 | SIGNOR-276343 |
| INSR | PIK3R1 | Tyr607 | NENTEDQySLVEDDE | phosphorylation up-regulates activity | 8385099 | SIGNOR-251322 |
| CSNK2A1 | PIK3R1 | Ser608 | ENTEDQYsLVEDDED | phosphorylation up-regulates activity | 14729945 | SIGNOR-276005 |
| PTPRJ | PIK3R1 | – | dephosphorylation down-regulates | 18348712 | SIGNOR-178049 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LCK | phosphorylation up-regulates → | PIK3R1 PTyr688 | phosphorylation down-regulates ⊣ | PIK3R1 | 9461588 | SIGNOR-251383 |
| INSR | phosphorylation up-regulates → | PIK3R1 PTyr580 | phosphorylation up-regulates → | PIK3R1 | 8385099 | SIGNOR-251321 |
| PPM1A | dephosphorylation down-regulates ⊣ | PIK3R1 PSer608 | dephosphorylation down-regulates ⊣ | PIK3R1 | 15016818 | SIGNOR-248489 |
| PRKD1 | phosphorylation up-regulates → | PIK3R1 PSer154 | phosphorylation up-regulates → | PIK3R1 | 23129748 | SIGNOR-276426 |
| INSR | phosphorylation up-regulates → | PIK3R1 PTyr368 | phosphorylation up-regulates → | PIK3R1 | 8385099 | SIGNOR-251320 |
| SIK2 | phosphorylation up-regulates → | PIK3R1 PSer154 | phosphorylation up-regulates → | PIK3R1 | 27478041 | SIGNOR-277269 |
| PIK3CA | phosphorylation up-regulates → | PIK3R1 PSer608 | phosphorylation up-regulates → | PIK3R1 | 14729945 | SIGNOR-276004 |
| PKA | phosphorylation up-regulates → | PIK3R1 PSer83 | phosphorylation up-regulates → | PIK3R1 | 21743495 | SIGNOR-276343 |
| INSR | phosphorylation up-regulates → | PIK3R1 PTyr607 | phosphorylation up-regulates → | PIK3R1 | 8385099 | SIGNOR-251322 |
| CSNK2A1 | phosphorylation up-regulates → | PIK3R1 PSer608 | phosphorylation up-regulates → | PIK3R1 | 14729945 | SIGNOR-276005 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| LCK | phosphorylation → down-regulates activity | PIK3R1 | SIGNOR-251383 |
| INSR | phosphorylation → up-regulates activity | PIK3R1 | SIGNOR-251321 |
| PPM1A | dephosphorylation → up-regulates activity | PIK3R1 | SIGNOR-248489 |
| PRKD1 | phosphorylation → up-regulates activity | PIK3R1 | SIGNOR-276426 |
| INSR | phosphorylation → up-regulates activity | PIK3R1 | SIGNOR-251320 |
| SIK2 | phosphorylation → up-regulates activity | PIK3R1 | SIGNOR-277269 |
| PIK3CA | phosphorylation → up-regulates activity | PIK3R1 | SIGNOR-276004 |
| PKA | phosphorylation → up-regulates activity | PIK3R1 | SIGNOR-276343 |
| INSR | phosphorylation → up-regulates activity | PIK3R1 | SIGNOR-251322 |
| CSNK2A1 | phosphorylation → up-regulates activity | PIK3R1 | SIGNOR-276005 |
| PTPRJ | dephosphorylation down-regulates | PIK3R1 | SIGNOR-178049 |