Summary

Name PIK3R1
Full Name Phosphatidylinositol 3-kinase regulatory subunit alpha
Synonyms PI3-kinase regulatory subunit alpha, PI3K regulatory subunit alpha, PtdIns-3-kinase regulatory subunit alpha, Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha, PI3-kinase subunit p85-alpha, PtdIns-3-kinase regulatory subunit p85-alpha | GRB1
Primary ID P27986
Links - -
Type protein
Relations 33
Pathways IGF and Myogenesis, Glioblastoma Multiforme, T cell activation, MTOR Signaling
Inhibitors LY294002
Function Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png dephosphorylation PIK3R1 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation PIK3R1 0.38
Publications: 3 Organism: Chlorocebus Aethiops
Pathways:MTOR Signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation PIK3R1 0.14
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:T cell activation
+ up-regulates activity img/direct-activation.png binding PIK3R1 0.48
Publications: 1 Organism: Rattus Norvegicus
Tissue: Skeletal Muscle
Pathways:MTOR Signaling, IGF and Myogenesis
+ up-regulates img/direct-activation.png binding PIK3R1 0.48
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination PIK3R1 0.53
Publications: 1 Organism: Homo Sapiens
Pathways:Glioblastoma Multiforme
+ down-regulates img/direct_inhibition.png dephosphorylation PIK3R1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/indirect-activation.png 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate 0.42
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates img/direct_inhibition.png chemical inhibition PIK3R1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates activity img/direct-activation.png binding PIK3R1 0.28
Publications: 2 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding PIK3R1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PIK3R1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PIK3R1 0.48
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png binding PIK3R1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PIK3R1 0.4
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PIK3R1 0.4
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PIK3R1 0.38
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ form complex img/form-complex.png binding PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding PIK3R1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PIK3CA 0.73
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:Glioblastoma Multiforme, MTOR Signaling, IGF and Myogenesis
+ up-regulates activity img/direct-activation.png binding PIK3R1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PIK3R1 0.22
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding PIK3R1 0.28
Publications: 2 Organism: Homo Sapiens
Tissue: Breast Cancer Cell
Pathways:Glioblastoma Multiforme
+ up-regulates img/direct-activation.png binding PIK3R1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Myotube
+ up-regulates activity img/direct-activation.png binding PIK3R1 0.47
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png binding PIK3CG 0.14
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png binding PIK3CB 0.48
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png binding PIK3CD 0.49
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png binding PIK3R1 0.36
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis