| + |
SIK2 | up-regulates activity 
phosphorylation
|
PIK3R1 |
0.327 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277269 |
Ser154 |
STLYRTQsSSNLAEL |
in vitro |
|
| pmid |
sentence |
| 27478041 |
The Regulatory Subunit of PI3K Is a Direct Catalytic Target of SIK2. These data confirm that p85α is a direct catalytic substrate of SIK2 and that SIK2 S154 phosphorylation significantly increases the activity of the PI3K/AKT pathway in ovarian cancer cells. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PRKD1 | up-regulates activity
phosphorylation
|
PIK3R1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276426 |
Ser154 |
STLYRTQsSSNLAEL |
Homo sapiens |
HL-60 Cell |
| pmid |
sentence |
| 23129748 |
PKD1 phosphorylates p85α to enhance its interaction with PTEN, leading to polarized PTEN activity, thereby regulating neutrophil migration. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPM1A | up-regulates activity
dephosphorylation
|
PIK3R1 |
0.33 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248489 |
Ser608 |
ENTEDQYsLVEDDED |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 15016818 |
Protein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytes|PP2Cα dephosphorylates the p85 subunit of PI3K, and dephosphorylation of the p85 subunit of PI3K at Ser608 increases its activity |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PIK3CA | up-regulates activity
phosphorylation
|
PIK3R1 |
0.934 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276004 |
Ser608 |
ENTEDQYsLVEDDED |
in vitro |
|
| pmid |
sentence |
| 14729945 |
We find that p110 alpha phosphorylates p85 alpha Ser608 in vivo with significant stoichiometry. However, p110 beta is far less efficient at phosphorylating p85 alpha Ser608, identifying a potential difference in the mechanisms by which these two isoforms are regulated. The p85 alpha Ser608 phosphorylation was increased by treatment with insulin, platelet-derived growth factor, and the phosphatase inhibitor okadaic acid. The functional effects of this phosphorylation are highlighted by mutation of Ser608, which results in reduced lipid kinase activity and reduced association of the p110 alpha catalytic subunit with p85 alpha. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Glioblastoma Multiforme, MTOR Signaling, IGF and Myogenesis |
| + |
CSNK2A1 | up-regulates activity
phosphorylation
|
PIK3R1 |
0.248 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276005 |
Ser608 |
ENTEDQYsLVEDDED |
in vitro |
|
| pmid |
sentence |
| 14729945 |
Protein kinase CK2 phosphorylates p85α on Ser608 when p85α is free but not when it is complexed with p110α. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PKA | up-regulates activity
phosphorylation
|
PIK3R1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276343 |
Ser83 |
YIGRKKIsPPTPKPR |
in vitro |
|
| pmid |
sentence |
| 21743495 |
in vitro kinase assays using purified protein kinase A (PKA) and either GST fused full length p85 (GST-p85) or GST fused p85 peptide spanning amino acids 50-109 (GST-p85Δ2) as substrate. Serine 83 phosphorylation on p85 is necessary for PI3K activation and membrane translocation in 14-3-3ζ overexpressing cells |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
INSR | up-regulates activity
phosphorylation
|
PIK3R1 |
0.656 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251320 |
Tyr368 |
STKMHGDyTLTLRKG |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 8385099 |
The alpha-type 85-kDa subunit of phosphatidylinositol 3-kinase is phosphorylated at tyrosines 368, 580, and 607 by the insulin receptor. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251321 |
Tyr580 |
LRKTRDQyLMWLTQK |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 8385099 |
The alpha-type 85-kDa subunit of phosphatidylinositol 3-kinase is phosphorylated at tyrosines 368, 580, and 607 by the insulin receptor. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251322 |
Tyr607 |
NENTEDQySLVEDDE |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 8385099 |
The alpha-type 85-kDa subunit of phosphatidylinositol 3-kinase is phosphorylated at tyrosines 368, 580, and 607 by the insulin receptor. |
|
| Publications: |
3 |
Organism: |
Chlorocebus Aethiops |
| Pathways: | MTOR Signaling |
| + |
LCK | down-regulates activity 
phosphorylation
|
PIK3R1 |
0.607 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251383 |
Tyr688 |
FAEPYNLySSLKELV |
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 9461588 |
the regulatory p85 subunit of phosphatidylinositol 3-kinase is phosphorylated on tyrosine residues. We report that this phosphorylation event is readily catalyzed by the Abl and Lck protein-tyrosine kinases in vitro, by Bcr-Abl or a catalytically activated Lck-Y505F in co-transfected COS cells. we have mapped a major phosphorylation site to Tyr-688 in the C-terminal SH2 domain of p85. Tyrosine phosphorylation of p85 in vitro or in vivo was not associated with detectable change in the enzymatic activity of the phosphatidylinositol 3-kinase heterodimer, but correlated with a strong reduction in the binding of some, but not all, phosphoproteins to the SH2 domains of p85. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| Pathways: | T cell activation |
| + |
PTK2 | up-regulates
binding
|
PIK3R1 |
0.536 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-53979 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9416004 |
Pi3-kinase has also been shown to bind fak in a cell cell adhesion-dipendent manner at the major autophosphorylation site y397. This association could live to activation of pi3-kinase and its downstream effectors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFBR2 | up-regulates activity
binding
|
PIK3R1 |
0.459 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217830 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19114990 |
in immunoprecipitation esperiments, the TGF _ RII receptor was found to be constitutively associated with p85, the regulatory subunity of PI3K |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TEK | up-regulates activity
binding
|
PIK3R1 |
0.517 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242634 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 14665640 |
Signal transduction pathways triggered by Tie2 have been extensively examined. Tyr-1101of Tie2 directly associates in a phosphotyrosine (pTyr)-dependent manner with the p85 regulatory subunit of phosphatidylinositol (PI) 3-kinase, which in turn activate PI 3-kinase, leading to cell motility and survival |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
GNAS | up-regulates
binding
|
PIK3R1 |
0.299 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-191561 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22179044 |
Notably, the fzd7 receptor complex was associated with g_?(s) and pi(3)k and these components were required for wnt7a to activate the akt/mtor growth pathway in myotubes. These data led us to hypothesize that g_?s Mediates the activation of pi3kinase following wnt7a binding to fzd7. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle, Myotube |
| + |
KDR | up-regulates activity
binding
|
PIK3R1 |
0.483 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261917 |
|
|
Homo sapiens |
HUVEC Cell |
| pmid |
sentence |
| 11278468 |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ESR1 | up-regulates
binding
|
PIK3R1 |
0.612 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-140470 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 16169518 |
Recently, it has been known that er activates phosphatidylinositol-3-oh kinase (pi3k) through binding with the p85 regulatory subunit of pi3k. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CD19 | up-regulates activity
binding
|
PIK3R1 |
0.567 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249608 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 10201980 |
Phosphorylation of CD19 Y484 and Y515, and linked activation of phosphatidylinositol 3-kinase, are required for B cell antigen receptor-mediated activation of Bruton's tyrosine kinase. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242900 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 25673924 |
CD19 has an extracellular region containing two C2-type Ig-like domains and a cytoplasmic region of ~240 amino acids with 9 conserved tyrosine residues24. Lyn, a Src-family protein tyrosine kinase member, is the dominant kinase that phosphorylates CD19 upon stimulation. Once tyrosyl-phosphorylated, CD19 serves as a membrane-bound adaptor protein for Src homology 2-containing signaling molecules such as Lyn, Vav, and phosphatidylinositol 3-kinase, which further mediate downstream activation cascades. |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| + |
FLT3 | up-regulates activity 
|
PIK3R1 |
0.547 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260081 |
|
|
Mus musculus |
BA/F3 Cell |
| pmid |
sentence |
| 23246379 |
Grb10 transduces signal from FLT3 by direct interaction with p85 and Ba/F3-FLT3-ITD cells expressing Grb10 exhibits higher STAT5 activation. These results suggest that Grb10 binds to both normal and oncogenic FLT3 and induces PI3K-Akt and STAT5 signaling pathways resulting in an enhanced proliferation, survival and colony formation of hematopoietic cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
GRB10 | up-regulates activity
binding
|
PIK3R1 |
0.411 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255945 |
|
|
Mus musculus |
BA/F3 Cell |
| pmid |
sentence |
| 23246379 |
Grb10 transduces signal from FLT3 by direct interaction with p85 and Ba/F3-FLT3-ITD cells expressing Grb10 exhibits higher STAT5 activation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
IRS1 | up-regulates activity
binding
|
PIK3R1 |
0.806 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175668 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 21798082 |
Phosphorylated irs then acts as docking site to recruit and activate phosphatidylinositol-3-kinase (pi3k) which phosphorylates membrane phospholipids, generating phosphoinositide-3,4,5-triphosphate (pip3) from phosphoinositide-4,5-biphosphate (pip2). |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Tissue: |
Skeletal Muscle |
| Pathways: | MTOR Signaling, IGF and Myogenesis |
| + |
PIK3R1 | form complex 
binding
|
PI3K |
0.934 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255300 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19805105 |
Phosphoinositol 3- kinase alpha (PI3Kα) is a heterodimeric enzyme formed by a catalytic subunit (p110α, encoded by PIK3CA) and one of several regulatory subunits (a major one being p85α, encoded by PI3KR1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | T cell activation |
| + |
DAB2IP | down-regulates activity
binding
|
PIK3R1 |
0.286 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254757 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27858941 |
DAB2IP binds the p85 subunit of PI3K through its PR domain and prevents PI3K-p85 relocation from the cytoplasm to the membrane, a necessary step for PI3K activation and signaling to AKT. Notably, DAB2IP reinforces this inhibitory effect by directly binding AKT.2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PIK3R1 | up-regulates activity
binding
|
PIK3CB |
0.846 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242640 |
|
|
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 14665640 |
Signal transduction pathways triggered by Tie2 have been extensively examined. Tyr-1101of Tie2 directly associates in a phosphotyrosine (pTyr)-dependent manner with the p85 regulatory subunit of phosphatidylinositol (PI) 3-kinase, which in turn activate PI 3-kinase, leading to cell motility and survival |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
LAT | up-regulates activity
binding
|
PIK3R1 |
0.417 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-246050 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11368773 |
By substituting these tyrosine residues in LAT with phenylalanine and by utilizing phosphorylated peptides derived from these sites, we mapped the tyrosine residues in LAT required for the direct interaction and activation of Vav, p85/p110alpha and phospholipase Cgamma1 (PLCgamma1). Our results indicate that Tyr(226) and Tyr(191) are required for Vav binding, whereas Tyr(171) and Tyr(132) are necessary for association and activation of phosphoinositide 3-kinase activity and PLCgamma1 respectively. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | T cell activation |
| + |
PIK3R1 | up-regulates activity
binding
|
PIK3CD |
0.822 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242643 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 14665640 |
Signal transduction pathways triggered by Tie2 have been extensively examined. Tyr-1101of Tie2 directly associates in a phosphotyrosine (pTyr)-dependent manner with the p85 regulatory subunit of phosphatidylinositol (PI) 3-kinase, which in turn activate PI 3-kinase, leading to cell motility and survival |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
TGFB1 | up-regulates activity
binding
|
PIK3R1 |
0.261 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217960 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19114990 |
While association of the TGF_RI receptor with p85 requires TGF-_ stimulation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CBL | down-regulates
ubiquitination
|
PIK3R1 |
0.68 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-110060 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 11526404 |
Cbl-b, a ring-type e3 ubiquitin protein ligase, is implicated in setting the threshold of t lymphocyte activation. The p85 regulatory subunit of phosphatidylinositol 3 kinase (pi3k) was identified as a substrate for cbl-b. We have shown that cbl-b negatively regulated p85 in a proteolysis-independent manner. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glioblastoma Multiforme |
| + |
EGFR | up-regulates
binding
|
PIK3R1 |
0.802 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-121959 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14967450 |
The egf-r coimmunoprecipitated with p85 alpha |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-33633 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 26918608 |
p85alpha promotes nucleolin transcription and subsequently enhances EGFR mRNA stability and EGF-induced malignant cellular transformation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Breast Cancer Cell |
| Pathways: | Glioblastoma Multiforme |
| + |
IGF1R | up-regulates
binding
|
PIK3R1 |
0.706 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179386 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18595745 |
Igf-1 activated both the pi3k and the extracellular signal-regulated kinase [?] (erk [?]) Pathways as evidenced by phosphorylation of either akt or erk1 [?]/2 (respectively) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IGF and Myogenesis |
| + |
LY294002 | down-regulates
chemical inhibition
|
PIK3R1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-79347 |
|
|
Homo sapiens |
Myoblast |
| pmid |
sentence |
| 10896679 |
Here we show that inhibition of pi3-k activity by the pharmacological agent ly294002 affects early processes of myoblast differentiation including the transcriptional activation of myogenin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
KIT | up-regulates activity
binding
|
PIK3R1 |
0.716 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255948 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 7509796 |
Tyrosine residue 719 of the c-kit receptor is essential for binding of the P85 subunit of phosphatidylinositol (PI) 3-kinase and for c-kit-associated PI 3-kinase activity in COS-1 cells |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
PIK3AP1 | up-regulates
binding
|
PIK3R1 |
0.61 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-191673 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 22187458 |
Bcap is constitutively phosphorylated and associated with the p85 subunit of pi3k in macrophages. Tlr signaling causes the phosphorylation of the small amount of bcap that is associated with membranes in the resting state or the translocation of phosphorylated bcap from the cytoplasm to the membrane. This accumulation of tyrosine-phosphorylated bcap at the membrane with its associated pi3k would then allow for the catalysis of ptd ins p2 to ptd ins p3 and downstream pi3k-dependent signals. Bcap is an essential activator of the pi3k pathway downstream of tlr signaling |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CBLB | down-regulates quantity by destabilization
polyubiquitination
|
PIK3R1 |
0.495 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272583 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 11087752 |
Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.Here it is shown that Cbl-b interacts with and induces ubiquitin conjugation to the p85 regulatory subunit of phosphatidylinositol 3-kinase, an upstream regulator of Vav. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFBR1 | up-regulates
binding
|
PIK3R1 |
0.389 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227525 |
|
|
Homo sapiens |
Respiratory Smooth Muscle |
| pmid |
sentence |
| 9435577 |
These studies revealed that PI 3-kinase is associated in vivo with both TGF-_ receptor subtypes and that TGF-_1 stimulation enhances PI 3-kinase activity associated with type I TGF-_ receptor in hASM cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFBR2 | up-regulates
binding
|
PIK3R1 |
0.459 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227521 |
|
|
Homo sapiens |
Respiratory Smooth Muscle |
| pmid |
sentence |
| 9435577 |
These studies revealed that PI 3-kinase is associated in vivo with both TGF-_ receptor subtypes and that TGF-_1 stimulation enhances PI 3-kinase activity associated with type I TGF-_ receptor in hASM cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPRJ | down-regulates
dephosphorylation
|
PIK3R1 |
0.264 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178049 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18348712 |
As reduction of pi3k activity by cd148 or shp-1 [32] is not large (2540%), it is likely that these ptps may function as modulators of the pi3k pathway rather than suppressors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PIK3R1 | up-regulates activity
binding
|
PIK3CA |
0.934 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242637 |
|
|
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 14665640 |
Signal transduction pathways triggered by Tie2 have been extensively examined. Tyr-1101of Tie2 directly associates in a phosphotyrosine (pTyr)-dependent manner with the p85 regulatory subunit of phosphatidylinositol (PI) 3-kinase, which in turn activate PI 3-kinase, leading to cell motility and survival |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| Pathways: | Glioblastoma Multiforme, MTOR Signaling, IGF and Myogenesis |
| + |
PIK3R1 | up-regulates activity
binding
|
PIK3CG |
0.712 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242646 |
|
|
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 14665640 |
Signal transduction pathways triggered by Tie2 have been extensively examined. Tyr-1101of Tie2 directly associates in a phosphotyrosine (pTyr)-dependent manner with the p85 regulatory subunit of phosphatidylinositol (PI) 3-kinase, which in turn activate PI 3-kinase, leading to cell motility and survival |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
PIK3R1 | up-regulates quantity
|
PIP3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175678 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 21798082 |
Phosphorylated irs then acts as docking site to recruit and activate phosphatidylinositol-3-kinase (pi3k) which phosphorylates membrane phospholipids, generating phosphoinositide-3,4,5-triphosphate (pip3) from phosphoinositide-4,5-biphosphate. (pip2). |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Pathways: | Glioblastoma Multiforme, MTOR Signaling, T cell activation |
| + |
ICOS | up-regulates activity
binding
|
PIK3R1 |
0.478 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272539 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18641334 |
ICOS ligation in concert with TCR stimulation results in strong PI3K activation in T lymphocytes. The ICOS cytoplasmic tail contains an YMFM motif that binds the p85alpha subunit of class IA PI3K, similar to the YMNM motif of CD28, suggesting a redundant function of the two receptors in PI3K signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BCAR1 | up-regulates activity
binding
|
PIK3R1 |
0.543 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263980 |
|
|
Homo sapiens |
HT-29 Cell |
| pmid |
sentence |
| 27447856 |
One such SH2-domain containing protein is the p85 subunit of PI3K, as its docking with tyrosine-phosphorylated p130cas activates the p110alpha subunit| tyrosine-165 and tyrosine-128 on p130cas both are phosphorylated to a greater extent in parental versus paxillin Y88F mutan |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PIK3R1
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